DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF543

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_998763.2	Gene:	ZNF543 / 125919	HGNCID:	25281	Length:	600	Species:	Homo sapiens

Alignment Length:	567	Identity:	145/567 - (25%)
Similarity:	231/567 - (40%)	Gaps:	104/567 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDK 93
            |....|   ||...|..:::     |.|....|.....|:        .||..|..|    :.::
Human    63 HRQELW---MATKDLSQSSY-----PGDNTKPKTTEPTFS--------HLALPEEVL----LQEQ 107

  Fly    94 IDASSLEDDEIGQ-EDLEPAEEHQET--------ETTKPTTTVSAETQPNNTASDPIEIFVDAVD 149
            :...:.::.::|| :|.:...|.||.        :..|....:|:|.  :...||      |.|.
Human   108 LTQGASKNSQLGQSKDQDGPSEMQEVHLKIGIGPQRGKLLEKMSSER--DGLGSD------DGVC 164

  Fly   150 IDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHD 214
            ....:::...|  ...|:.:...|:||.....:.. ||.|:.|   .:.::...||::| ...|.
Human   165 TKITQKQVSTE--GDLYECDSHGPVTDALIREEKN-SYKCEEC---GKVFKKNALLVQH-ERIHT 222

  Fly   215 PEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECAL 279
            ..:||.|.||...|..:.....||.....||.:.|..|||.:..|.:|..|...:..|..::|:.
Human   223 QVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYKCSE 287

  Fly   280 CEKRFYTRKSLNYHMKWHNPDRQFKCR------------------HSG--------CERLFISQR 318
            |.|.|..|.:...|.:.|..::.|.|:                  |:|        |.:.|..:.
Human   288 CGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFNRRS 352

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            :|..|:..|:|.   |...|..|||.|.....|..| |..|.|||||||..|.:.|    .:|.|
Human   353 YLTWHQQIHTGV---KPFECNECGKAFCESADLIQH-YIIHTGEKPYKCMECGKAF----NRRSH 409

  Fly   384 MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGL 448
             |::|:...|..:..||..|.:.|:.....:.|......::|
Human   410 -LKQHQRIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKP----------------------- 450

  Fly   449 FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGK 513
            ::|..|.:.|:.::.|.||.::|: .::|:.|..|.|.|.|:..:..|.:.|..|||..|..|||
Human   451 YECKECGKAFSDRADLIRHFSIHT-GEKPYECVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGK 514

  Fly   514 AFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            ||.....|.:|.:.| ..||.::|:.||:|:....||..|||.|||:
Human   515 AFCRSANLIRHSIIH-TGEKPYECSECGKAFNRGSSLTHHQRIHTGR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/57 (23%)
		COG5048	198..>508	CDD:227381	87/335 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/47 (15%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF543	NP_998763.2	KRAB	9..69	CDD:214630	2/8 (25%)
		COG5048	<75..329	CDD:227381	61/285 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131		4/20 (20%)
		C2H2 Zn finger	201..221	CDD:275368	5/23 (22%)
		COG5048	223..562	CDD:227381	106/372 (28%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		C2H2 Zn finger	313..333	CDD:275368	1/19 (5%)
		C2H2 Zn finger	341..361	CDD:275368	4/19 (21%)
		C2H2 Zn finger	369..389	CDD:275368	8/20 (40%)
		C2H2 Zn finger	397..417	CDD:275368	7/24 (29%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100