DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF816

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001026835.1	Gene:	ZNF816 / 125893	HGNCID:	26995	Length:	651	Species:	Homo sapiens

Alignment Length:	415	Identity:	124/415 - (29%)
Similarity:	189/415 - (45%)	Gaps:	46/415 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 KFCLRP---QEN-----YQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQ 246
            :.|:|.   |.|     :....||..| :.:|..|:.|.|..|...|........|.:....||.
Human   221 EICMREKPCQSNECGKAFNYSSLLRRH-HITHSREREYKCDVCGKIFNQKQYIVYHHRCHTGEKT 284

  Fly   247 HACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCE 311
            :.|..|||.:....:|..|...:..|..::|..|.|.|..:.||..|.:.|..::.:||..  |.
Human   285 YKCNECGKTFTQMSSLVCHRRLHTGEKPYKCNECGKTFSEKSSLRCHRRLHTGEKPYKCNE--CG 347

  Fly   312 RLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFAS 376
            :.|.....|:.|:|.|:|   .|...|..|||||....:|:.| :..|.|||||||..|..|:.
Human   348 KTFGRNSALVIHKAIHTG---EKPYKCNECGKTFSQKSSLQCH-HILHTGEKPYKCEECDNVYI- 407

  Fly   377 YAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKR 441
               :|.| |||||:..|.....:|.:|.:.|.|:..|..|......::|
Human   408 ---RRSH-LERHRKIHTGEGSYKCKVCDKVFRSDSYLAEHQRVHTGEKP---------------- 452

  Fly   442 ERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPN 506
                   ::|..|.:.|:.||:|:.|..:|: .::|:.|..|.|.|.|.:::..|.:.|..|||.
Human   453 -------YKCNKCGRSFSRKSSLQYHHTLHT-GEKPYTCNECGKVFSRRENLARHHRLHAGEKPY 509

  Fly   507 VCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQER 571
            .|:.|.|.|:.:..|.:||..| ..||.:||.||.:|:..:..|..|.|.|||:..|||:.|.:.
Human   510 KCEECDKVFSRRSHLERHRRIH-TGEKPYKCKVCDKAFRSDSCLANHTRVHTGEKPYKCNKCAKV 573

  Fly   572 FVTHIKLKTHMQKAHAASQPHSADQ 596
            |.....|..| |:.|...:|:..::
Human   574 FNQKGILAQH-QRVHTGEKPYKCNE 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/314 (29%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF816	NP_001026835.1	KRAB	24..64	CDD:307490
		C2H2 Zn finger	232..251	CDD:275368	4/19 (21%)
		C2H2 Zn finger	259..279	CDD:275368	4/19 (21%)
		COG5048	283..650	CDD:227381	109/352 (31%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..391	CDD:275368	8/20 (40%)
		C2H2 Zn finger	399..419	CDD:275368	10/24 (42%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	7/19 (37%)
		C2H2 Zn finger	567..587	CDD:275368	6/20 (30%)
		C2H2 Zn finger	595..615	CDD:275368	0/3 (0%)
		C2H2 Zn finger	623..643	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100