DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF354B

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_478137.1	Gene:	ZNF354B / 117608	HGNCID:	17197	Length:	612	Species:	Homo sapiens

Alignment Length:	440	Identity:	128/440 - (29%)
Similarity:	174/440 - (39%)	Gaps:	103/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            :.||.||:.   :.....|::| ..:|..|:||.|.||...|..:||...||::..|||.:.|..
Human   242 FKCKECLKA---FSQSSALIQH-QRTHTGEKPYICKECGKAFSHSASLCKHLRTHTVEKCYRCKE 302

  Fly   252 CGKKYGDRHNLRHHVEKYHSETD-----------------------------FECALCEKRFYTR 287
            |||.:..|..|..| :|.|::.:                             :.|..|...|.:.
Human   303 CGKSFSRRSGLFIH-QKIHAQENPHKYNPGRKASSYSTSLSGSQKIHLRKKSYLCNECGNTFKSS 366

  Fly   288 KSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLR 352
            .||.||.:.|..::.|||  |.|.|.|.....|:.||
Human   367 SSLRYHQRIHTGEKPFKC--SECGRAFSQSASLIQHE---------------------------- 401

  Fly   353 WHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHM 417
                |.|.|||||:|..|.:.|.|     |..|.|||...|..:...|..|.:..||...||.|
Human   402 ----RIHTGEKPYRCNECGKGFTS-----ISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIH- 456

  Fly   418 SAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHAC 480
                                    ||.::|  ..:|..|.:.|...|||.:|..:|: .:||:.|
Human   457 ------------------------ERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHT-GERPYKC 496

  Fly   481 PHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYL 545
            ..|.|.|:....:..|.:.|..|||..|..||.:|.....|.||:..| ..||.||||.||:.:.
Human   497 NECDKTFRCNSSLSNHQRIHTGEKPYRCLECGMSFGQSAALIQHQRIH-TGEKPFKCNTCGKTFR 560

  Fly   546 FEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSAD 595
            ...||..|||.|||:..|:|:.|.:.|.....|..| .|.|.......||
Human   561 QSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNH-YKIHIEEDSLKAD 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	90/340 (26%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	1/20 (5%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF354B	NP_478137.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..102
		COG5048	184..596	CDD:227381	123/424 (29%)
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368
		zf-H2C2_2	228..253	CDD:290200	4/13 (31%)
		C2H2 Zn finger	244..264	CDD:275368	6/23 (26%)
		zf-H2C2_2	256..281	CDD:290200	10/25 (40%)
		C2H2 Zn finger	272..292	CDD:275368	8/19 (42%)
		zf-C2H2	298..320	CDD:278523	8/22 (36%)
		C2H2 Zn finger	300..320	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..340		1/19 (5%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		zf-H2C2_2	368..393	CDD:290200	12/26 (46%)
		C2H2 Zn finger	384..404	CDD:275368	9/53 (17%)
		zf-H2C2_2	396..421	CDD:290200	13/56 (23%)
		C2H2 Zn finger	412..432	CDD:275368	9/24 (38%)
		C2H2 Zn finger	440..460	CDD:275368	9/44 (20%)
		zf-H2C2_2	453..477	CDD:290200	9/48 (19%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		zf-H2C2_2	480..505	CDD:290200	10/25 (40%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		zf-H2C2_2	508..531	CDD:290200	8/22 (36%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	12/25 (48%)
		C2H2 Zn finger	552..572	CDD:275368	9/19 (47%)
		zf-H2C2_2	564..589	CDD:290200	12/24 (50%)
		C2H2 Zn finger	580..600	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100