DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF526

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001300962.1	Gene:	ZNF526 / 116115	HGNCID:	29415	Length:	670	Species:	Homo sapiens

Alignment Length:	608	Identity:	138/608 - (22%)
Similarity:	216/608 - (35%)	Gaps:	179/608 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEE----HQETE---- 119
            |.:|.....|.... ||.|:|.|:.|       |:.::......::|.|:.|    |::.:
Human   110 CGECSQLILSPGEL-LAHQDAHLRES-------ANQIQYQCWDCQELFPSPELWVAHRKAQHLSA 166

  Fly   120 ---------TTKPTTTVSAETQPNNTASDPIEI------------FVD--AVDIDEAEEEE---- 157
                     ...|.|.:...:.|:....:|.|.            |::  ....|..|:||
Human   167 TVAEPPVPPPLPPPTPLPPPSPPSEVKMEPYECPECSTLCATPEEFLEHQGTHFDSLEKEERNGL 231

  Fly   158 EEEEQQQQYDEEVEEPITDESAPPQL----------TISYA--CKFCLRPQENYQLQQLLLEHIN 210
            ||||:..:.|||.:|.:.||.|..::          |..:|  |..|.:.|.:...::   :|..
Human   232 EEEEEDDEEDEEDDEEMEDEEAMAEVGDDAVGGDESTAGWAQGCGDCPQHQPSAGARR---QHRR 293

  Fly   211 ASHDP---EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSE 272
            .:|.|   ..|::|.:|:..|..|.....|.: :||...|.|..|.|.:....:|..|:..:..|
Human   294 TAHSPASATHPFHCSQCQRSFSSANRLQAHGR-AHVGGTHECTTCSKVFKKAASLEQHLRLHRGE 357

  Fly   273 TDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEH 337
            ..:.|..|.:.|.|..:|..|.:.|..:...:||
Human   358 ARYLCVDCGRGFGTELTLVAHRRAHTANPLHRCR------------------------------- 391

  Fly   338 CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECML 402
               |||||.::....:| .|.|.|:........|
Human   392 ---CGKTFSNMTKFLYH-RRTHAGKSGAPPTGAT------------------------------- 421

  Fly   403 CRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERH 467
             ..|..:||.......|...|.|                         |..||:.|...|.|.||
Human   422 -APPAPAEPTPPPPPPAPPAQLP-------------------------CPQCSKSFASASRLSRH 460

  Fly   468 -AAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL 531
             .|||...:|.|.|..|.|.||:...::.|::||..|:|..|..|||.||....|::|:|:| ..
Human   461 RRAVHGPPERRHRCGVCGKGFKKLIHVRNHLRTHTGERPFQCHSCGKTFASLANLSRHQLTH-TG 524

  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTH--------------TG---KTYYKCDLCQERFVTHIKLK 579
            .:.::|..||:.:....:|:.|:|.|              ||   |:.|.|..|...|.....|:
Human   525 ARPYQCLDCGKRFTQSSNLQQHRRLHLRPVAFARAPRLPITGLYNKSPYYCGTCGRWFRAMAGLR 589

  Fly   580 THMQKAHAAS-----QPHSADQP 597
            .| |:.||.:     ||..:..|
Human   590 LH-QRVHARARTLTLQPPRSPSP 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	8/23 (35%)
		COG5048	198..>508	CDD:227381	66/313 (21%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	2/21 (10%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	9/20 (45%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF526	NP_001300962.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..196		3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..304		23/89 (26%)
		C2H2 Zn finger	275..296	CDD:275368	4/23 (17%)
		C2H2 Zn finger	307..327	CDD:275368	5/20 (25%)
		C2H2 Zn finger	334..354	CDD:275368	5/19 (26%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..409	CDD:275368	9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..443		8/65 (12%)
		COG5048	<441..550	CDD:227381	41/134 (31%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		zf-H2C2_2	486..511	CDD:290200	10/24 (42%)
		C2H2 Zn finger	502..522	CDD:275368	9/19 (47%)
		zf-H2C2_2	514..539	CDD:290200	7/25 (28%)
		C2H2 Zn finger	530..550	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..621		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100