DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF689

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_612456.1	Gene:	ZNF689 / 115509	HGNCID:	25173	Length:	500	Species:	Homo sapiens

Alignment Length:	379	Identity:	111/379 - (29%)
Similarity:	162/379 - (42%)	Gaps:	45/379 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 CPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFY 285
            ||:|...|.|..:...|..:.:::|.:.|..||:::.....|..|...:..|..:.|..|.|||.
Human   151 CPDCGCTFPDHQALESHKCAQNLKKPYPCPDCGRRFSYPSLLVSHRRAHSGECPYVCDQCGKRFS 215

  Fly   286 TRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
            .||:|:.|...|..::.:.|  ..|.|.|...|.|..|..||:|   .|...|..||:.|.:...
Human   216 QRKNLSQHQVIHTGEKPYHC--PDCGRCFRRSRSLANHRTTHTG---EKPHQCPSCGRRFAYPSL 275

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVF----ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            |..| .|.|.|||||.|..|...|    |....:|||         |..:...|..|.:.|||..
Human   276 LAIH-QRTHTGEKPYTCLECNRRFRQRTALVIHQRIH---------TGEKPYPCPDCERRFSSSS 330

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDR 476
            .|:.|......:||                       :.|..|..||:.:|.|.:|..:|: .::
Human   331 RLVSHRRVHSGERP-----------------------YACEHCEARFSQRSTLLQHQLLHT-GEK 371

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            |:.||.|.:.|:|:..:..|..||.:||.:.||.||:.||...:|..||..|.. |:.:.|::|.
Human   372 PYPCPDCGRAFRRSGSLAIHRSTHTEEKLHACDDCGRRFAYPSLLASHRRVHSG-ERPYACDLCS 435

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAAS-QPHSA 594
            :.:.....|..||..|||:..:.|..|...|.....|..|.....|.: .|.||
Human   436 KRFAQWSHLAQHQLLHTGEKPFPCLECGRCFRQRWSLAVHKCSPKAPNCSPRSA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	83/290 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF689	NP_612456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		KRAB	29..88	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..146
		C2H2 Zn finger	151..171	CDD:275368	6/19 (32%)
		COG5048	159..>466	CDD:227381	100/346 (29%)
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	207..227	CDD:275368	9/19 (47%)
		C2H2 Zn finger	235..255	CDD:275368	7/21 (33%)
		C2H2 Zn finger	263..283	CDD:275368	7/20 (35%)
		C2H2 Zn finger	291..311	CDD:275368	5/19 (26%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		C2H2 Zn finger	431..451	CDD:275368	5/19 (26%)
		C2H2 Zn finger	459..475	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100