DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZIM3

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_443114.1	Gene:	ZIM3 / 114026	HGNCID:	16366	Length:	472	Species:	Homo sapiens

Alignment Length:	513	Identity:	118/513 - (23%)
Similarity:	202/513 - (39%)	Gaps:	136/513 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 ETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQ---------------QQQYDE 168
            |||||...:.                     :::.:|...|||:               |....:
Human    51 ETTKPDVILR---------------------LEQGKEPWLEEEEVLGSGRAEKNGDIGGQIWKPK 94

  Fly   169 EVEEPITDESAPPQLTISYACKFCLRPQENYQL---QQLL---------LEHI--NASHDPE--- 216
            :|:|.:..|  .|.:.     |..|..|:..:.   :::|         |:|.  |.|||..
Human    95 DVKESLARE--VPSIN-----KETLTTQKGVECDGSKKILPLGIDDVSSLQHYVQNNSHDDNGYR 152

  Fly   217 ------------QPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKY 269
                        |...|..|...|...:....||:....:|...|..||:.:|::..|..|.:.:
Human   153 KLVGNNPSKFVGQQLKCNACRKLFSSKSRLQSHLRRHACQKPFECHSCGRAFGEKWKLDKHQKTH 217

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRK 334
            ..|..::|..|...:..:.:|..|.|.|..::.::|:  .|.:.|..:...:.||..|   :::|
Human   218 AEERPYKCENCGNAYKQKSNLFQHQKMHTKEKPYQCK--TCGKAFSWKSSCINHEKIH---NAKK 277

  Fly   335 SEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSE 399
            |..|..|.|:|....||..| .:.|.|:||::|.:|.:.|                    |.:|
Human   278 SYQCNECEKSFRQNSTLIQH-KKVHTGQKPFQCTDCGKAF--------------------IYKS- 320

  Fly   400 CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSAL 464
                        ||:.|......::|                       ::|..|.:.|:.||.:
Human   321 ------------DLVKHQRIHTGEKP-----------------------YKCSICEKAFSQKSNV 350

  Fly   465 ERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
            ..|..:|:.| |.:.|..|...|.:.:::..|.|.|..|||..|:.|||||..|..|..|:.:|.
Human   351 IDHEKIHTGK-RAYECDLCGNTFIQKKNLIQHKKIHTGEKPYECNRCGKAFFQKSNLHSHQKTHS 414

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHA 587
            . |:.::|:.||:.::.:.:|.||::||||:..|.|..|.:.|.....|..|.::.|:
Human   415 G-ERTYRCSECGKTFIRKLNLSLHKKTHTGQKPYGCSECGKAFADRSYLVRHQKRIHS 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	73/338 (22%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZIM3	NP_443114.1	KRAB	8..68	CDD:214630	6/37 (16%)
		C2H2 Zn finger	169..189	CDD:275368	5/19 (26%)
		zf-C2H2_8	172..241	CDD:318181	15/68 (22%)
		C2H2 Zn finger	197..217	CDD:275368	6/19 (32%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		zf-H2C2_2	237..261	CDD:316026	6/25 (24%)
		C2H2 Zn finger	253..273	CDD:275368	5/21 (24%)
		C2H2 Zn finger	281..301	CDD:275368	7/20 (35%)
		COG5048	<304..465	CDD:227381	55/218 (25%)
		C2H2 Zn finger	309..329	CDD:275368	8/52 (15%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..470	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100