DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	418	Identity:	125/418 - (29%)
Similarity:	191/418 - (45%)	Gaps:	29/418 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            |.|..|   .:.::.:.:|..| :..|..|:||.|.||...|...:|.|.|.:....||.:.|..
Human   326 YKCNEC---GKTFRQKSILTRH-HRLHTGEKPYKCNECGKTFSHKSSLTCHHRLHTGEKPYKCNE 386

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS 316
            |||.:..:.:|..|...:..|..::|..|:|.:..|.:...|.|.|..|..:||..  |.:.|..
Human   387 CGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNE--CGKTFSR 449

  Fly   317 QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381
            ...|.||...|:|....|   |..|.|.|.....|..| .|.|.|||||||..|.:.|:    ::
Human   450 TSSLTCHRRRHTGEQPYK---CEECDKAFRFKSNLERH-RRIHTGEKPYKCNECGKTFS----RK 506

  Fly   382 IHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQK 440
            .::...||.: |..:..:|..|.:.||.:..|..|......::|      |...   |:::..::
Human   507 SYLTCHHRLH-TGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTF---NQQLTLKR 567

  Fly   441 RERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKE 503
            ..|.:||  .::|....:.::.||.||.|..:|:| :.|:.|..|.|.|.|...:..|.:.|..|
Human   568 HRRLHSGENPYKCEDSDKAYSFKSNLEIHQKIHTE-ENPYKCNECGKTFSRTSSLTCHRRLHTGE 631

  Fly   504 KPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLC 568
            ||..|:.|.|||.:|..|..||..| ..||.:|||.||:.:..:.....|.|.|||:..|||:.|
Human   632 KPYKCEECDKAFRVKSNLEGHRRIH-TGEKPYKCNECGKTFSRKSYFICHHRLHTGEKPYKCNEC 695

  Fly   569 QERFVTHIKLKTHMQKAHAASQPHSADQ 596
            .:.|.....|..| .:.|...:|:..::
Human   696 GKNFSQKSSLICH-HRLHTGEKPYKCNE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/317 (29%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490
		C2H2 Zn finger	217..237	CDD:275368
		COG5048	242..617	CDD:227381	88/309 (28%)
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..348	CDD:275368	4/23 (17%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	6/21 (29%)
		C2H2 Zn finger	468..488	CDD:275368	7/20 (35%)
		C2H2 Zn finger	496..516	CDD:275368	5/23 (22%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	552..572	CDD:275368	3/22 (14%)
		C2H2 Zn finger	580..600	CDD:275368	6/19 (32%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	9/19 (47%)
		SFP1	<651..737	CDD:227516	24/74 (32%)
		C2H2 Zn finger	664..684	CDD:275368	6/19 (32%)
		C2H2 Zn finger	692..712	CDD:275368	5/20 (25%)
		C2H2 Zn finger	720..740	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100