DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Gm12258

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001359510.1	Gene:	Gm12258 / 108167848	MGIID:	3651534	Length:	627	Species:	Mus musculus

Alignment Length:	633	Identity:	161/633 - (25%)
Similarity:	248/633 - (39%)	Gaps:	131/633 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLP---------------QKI--CSDCFTKF 70
            |..|.|:..:..|..:.::..:...|....:|:..||               |||  ||....|
Mouse    42 SSLLSLNQCDAKPELILKLEKEAEPWKEDDAPDQSLPDMQNVDDRNEVSQDSQKIRRCSLVIAK- 105

  Fly    71 CSINAFRLACQEAQLKLSH-IYD----KIDASSLEDDEIGQED-----LEPAEEHQETETTKPTT 125
            .|::|.|....:| |..|| :.|    ...:|.:....:...|     .||:|.....|...|..
Mouse   106 SSVSAERAPAGKA-LSSSHRVLDLAIKNSTSSGMSPGPLNMRDRMLLPREPSEMQARKELGLPDV 169

  Fly   126 TVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVE----EPITDESAPPQLTIS 186
            |..:...|     :|:.::          ...|.|||..||....|    :|:..:.|.|....|
Mouse   170 TRVSPRLP-----EPLSLY----------RSTECEEQHVQYCGPSEAFHVKPVWLQKAFPMSNPS 219

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            ..    ||.... :|::|.|.....:....|.:.|..|...|...:..|.||| .|.||:
Mouse   220 SK----LRDYRK-ELEKLALPAKGETRAQVQTFECKVCGKLFCKNSHLTQHLK-MHKEKR----- 273

  Fly   252 C--GKKYGDRHNLRHHVEKYHS----ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGC 310
            |  |.......|::..:.|:.|    |..:.|...||....:...:...|... |.:..|..:.|
Mouse   274 CYKGSNCEPILNIQPKLPKHQSLRAGEELYTCNGDEKYIRPKSGKSVQQKIIG-DGRIVCGKTEC 337

  Fly   311 ERLFIS-QRHLMCHEATH----SGTSSRKSE--------------HCGFCGKTFIHLKTLRWHIY 356
            .:|..| :::.:.||.||    :|.:.|||:              .|..|||||.|..    |:|
Mouse   338 SKLNCSVEQNPLKHEETHEFSLAGKTVRKSDLHQLETPHRYERVYECSACGKTFSHTP----HVY 398

  Fly   357 RQHGGEKPYKCANCTE---VFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMS 418
            ...|.||||:|.:|.:   |.:..|.             |..:|..|.:|.:.|.....|..|..
Mouse   399 SPSGAEKPYECEDCQQSKLVVSQPAP-------------TQEKRYVCNVCGKAFYKRAHLHAHQR 450

  Fly   419 AEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHC 483
            ....::|                       :.|..|.:.|.:||.|..|..:|: .::|.||..|
Mouse   451 THTGEKP-----------------------YDCQECGKSFRLKSFLVVHQRIHT-GEKPFACDTC 491

  Fly   484 SKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEK 548
            .|.||:...:..||:.|..|||..|..|.|:|.||..||.|:.:|.. ||.::|:|||:::....
Mouse   492 GKSFKQRTSLYTHIRIHTGEKPYECKECRKSFILKSYLTVHQRTHSG-EKPYECDVCGKSFKQNS 555

  Fly   549 SLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            .|..|:||||.:..|:|.:|.:.:.....|.|| :|.|.:.:|:...|
Mouse   556 HLHAHKRTHTSEKPYECIVCGKSYKQSPSLYTH-KKIHTSEKPYECKQ 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	19/80 (24%)
		COG5048	198..>508	CDD:227381	84/337 (25%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	3/21 (14%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	305..327	CDD:275368	6/22 (27%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/19 (21%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Gm12258	NP_001359510.1	KRAB	8..67	CDD:214630	4/24 (17%)
		C2H2 Zn finger	249..269	CDD:275370	7/20 (35%)
		C2H2 Zn finger	384..424	CDD:275368	17/43 (40%)
		COG5048	<412..608	CDD:227381	64/230 (28%)
		C2H2 Zn finger	432..452	CDD:275368	5/19 (26%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	9/19 (47%)
		C2H2 Zn finger	544..564	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	6/20 (30%)
		zf-C2H2	598..620	CDD:333835	1/5 (20%)
		C2H2 Zn finger	600..620	CDD:275368	1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100