DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF211

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001252526.1	Gene:	ZNF211 / 10520	HGNCID:	13003	Length:	629	Species:	Homo sapiens

Alignment Length:	530	Identity:	137/530 - (25%)
Similarity:	207/530 - (39%)	Gaps:	96/530 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 EHQETETTKPTTTVSAETQP---------NNTASDPIEI----FVDAVDIDEAE----------- 154
            ||:||.:.:   .:|.|..|         ::..:|..||    ..|.:.:.|.:
Human   144 EHEETPSEQ---RISGERVPQFRTSKEGSSSQNADSCEICCLVLRDILHLAEHQGTNCGQKLHTC 205

  Fly   155 ------EEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACK--FCLRPQENYQLQQLLLEHINA 211
                  ....::.|:|...|.......|.::..|..|.:..:  |..|......|..:...|.:|
Human   206 GKQFYISANLQQHQRQHITEAPFRSYVDTASFTQSCIVHVSEKPFTCREIRKDFLANMRFLHQDA 270

  Fly   212 SHDPEQPYNCPECEARFQDAASRTVHLKS----SHV------------EKQHACGVCGKKYGDRH 260
            :...|:|.|..:|...|....|.....|.    ||:            |....|..|||....|.
Human   271 TQTGEKPNNSNKCAVAFYSGKSHHNWGKCSKAFSHIDTLVQDQRILTREGLFECSKCGKACTRRC 335

  Fly   261 NLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEA 325
            ||..|.:.:..|..:||..|.|.|....|...|.:.|..:|.:.|..  |.:.|.....|..|..
Human   336 NLIQHQKVHSEERPYECNECGKFFTYYSSFIIHQRVHTGERPYACPE--CGKSFSQIYSLNSHRK 398

  Fly   326 THSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANC----TEVFASYAEKRIHMLE 386
            .|:|   .:...||.|||:|.....|..| .|.|.||:||:|:.|    ::.|:....:|:|..|
Human   399 VHTG---ERPYECGECGKSFSQRSNLMQH-RRVHTGERPYECSECGKSFSQNFSLIYHQRVHTGE 459

  Fly   387 RHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQC 451
            |..         ||..|.:.||....||||......:||                       ::|
Human   460 RPH---------ECNECGKSFSRSSSLIHHRRLHTGERP-----------------------YEC 492

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.|...|:...|..||: .:||:.|..|.|.|..:.::|.|.:.|..|:|..|..|.|:|:
Human   493 SKCGKSFKQSSSFSSHRKVHT-GERPYVCGECGKSFSHSSNLKNHQRVHTGERPVECSECSKSFS 556

  Fly   517 LKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            .|..|.:|...| ..|:.::|:.||:::....||..|:|.||||..|:|..|.:.|.....|..|
Human   557 CKSNLIKHLRVH-TGERPYECSECGKSFSQSSSLIQHRRVHTGKRPYQCSQCGKSFGCKSVLIQH 620

  Fly   582 MQKAHAASQP 591
             |:.|...:|
Human   621 -QRVHIGEKP 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/329 (27%)
		C2H2 Zn finger	221..241	CDD:275368	4/23 (17%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF211	NP_001252526.1	KRAB	46..106	CDD:214630
		KRAB	46..85	CDD:279668
		COG5048	244..615	CDD:227381	114/410 (28%)
		C2H2 Zn finger	299..316	CDD:275368	2/16 (13%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	336..361	CDD:290200	9/24 (38%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		zf-H2C2_2	368..389	CDD:290200	6/22 (27%)
		C2H2 Zn finger	380..400	CDD:275368	5/21 (24%)
		zf-H2C2_2	392..417	CDD:290200	10/27 (37%)
		C2H2 Zn finger	408..428	CDD:275368	9/20 (45%)
		zf-H2C2_2	420..445	CDD:290200	10/25 (40%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		zf-H2C2_2	448..473	CDD:290200	8/33 (24%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		zf-C2H2	518..540	CDD:278523	6/21 (29%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		zf-H2C2_2	532..557	CDD:290200	9/24 (38%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		zf-H2C2_2	560..585	CDD:290200	7/25 (28%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		zf-H2C2_2	588..611	CDD:290200	11/22 (50%)
		C2H2 Zn finger	604..624	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100