DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Gm6871

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001365582.1	Gene:	Gm6871 / 102642386	MGIID:	3643456	Length:	438	Species:	Mus musculus

Alignment Length:	400	Identity:	113/400 - (28%)
Similarity:	175/400 - (43%)	Gaps:	74/400 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RPQENYQLQQLLLEH----INASHDP-EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCG 253
            :|.|.:|..:.|..|    |:...|. ::||.|.:|:..|........|.::...:|.:.|..||
Mouse   101 KPSEGFQHIEALACHSSLQIHKRTDTGKKPYKCNQCDKVFSQQRHLRTHERTHTGKKPYECDQCG 165

  Fly   254 KKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            |.:..:..|..|...:..|..:||..|.|.|....::..|.:.|..::.::|  ..|.:.|..|.
Mouse   166 KAFAYQSALVLHKRTHTGEKPYECDQCGKAFAHHFTVVLHKRTHTGEKPYEC--DQCGKAFAYQS 228

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIH 383
            .|:.|:.||:|   .|...|..|||||..:..||.|.. .|.|||||||..|.:.|:..:..|||
Mouse   229 ALVLHKRTHTG---EKPYECNQCGKTFAQINHLRTHKV-VHTGEKPYKCNQCDKAFSQQSHLRIH 289

  Fly   384 MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG- 447
                                                                      ||.::|
Mouse   290 ----------------------------------------------------------ERTHTGE 296

  Fly   448 -LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
             .::|..|.:.|...|.|:.|..:|: .::|:.|..|.|.|.:...::.|.:||..|||..|:.|
Mouse   297 KPYKCNQCGKSFVSHSHLQSHGRIHT-GEKPYKCNQCDKAFAQHNSLQIHKRTHTGEKPYKCNQC 360

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHI 576
            .||||....|..|:.:| ..||.::|:.||:|:....::.||:|||||:..|:||.|.:.|..|.
Mouse   361 DKAFAQSSSLQYHKRTH-TGEKPYECDQCGKAFTHPSTVVLHKRTHTGEKPYECDQCGKAFAHHS 424

  Fly   577 KLKTHMQKAH 586
            .|:.| :|.|
Mouse   425 TLQYH-KKNH 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	79/316 (25%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
Gm6871	NP_001365582.1	KRAB	4..44	CDD:396083
		C2H2 Zn finger	133..153	CDD:275368	4/19 (21%)
		zf-H2C2_2	145..170	CDD:404364	6/24 (25%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		zf-H2C2_2	173..198	CDD:404364	8/24 (33%)
		C2H2 Zn finger	189..209	CDD:275368	5/19 (26%)
		zf-H2C2_2	205..226	CDD:404364	5/22 (23%)
		C2H2 Zn finger	217..237	CDD:275368	6/21 (29%)
		COG5048	<241..421	CDD:227381	70/240 (29%)
		C2H2 Zn finger	245..265	CDD:275368	9/20 (45%)
		C2H2 Zn finger	273..293	CDD:275368	8/77 (10%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	413..433	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100