DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Gm35315

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_011247932.1	Gene:	Gm35315 / 102638847	MGIID:	5594474	Length:	588	Species:	Mus musculus

Alignment Length:	465	Identity:	135/465 - (29%)
Similarity:	207/465 - (44%)	Gaps:	53/465 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 EEPITDESAPPQ-LTI---------SYACKFCLRP----------------QENYQLQQL----- 204
            |:|..:..||.. |.|         .|.|..|.:.                |:.|:..|.
Mouse   117 EKPYGESFAPTSGLQICKIIHTGEKPYKCNQCGKAFARLSYLQMHKITHSGQKTYKCDQCGKAFA 181

  Fly   205 ---LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHV 266
               .|:....:|..|:||.|.:|...|........|.:....||.:.|..|||.:....|||.|.
Mouse   182 YPGYLQVHKRTHTGEKPYECKQCSKAFAFPGHLQRHERIHTGEKPYKCSDCGKAFAFNTNLRVHK 246

  Fly   267 EKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTS 331
            ..:..|..:||..|.|.|.:...|:||.:.|..::.:||..  |::.:....||..|:.||:|
Mouse   247 ATHTGEKPYECKQCSKSFASHGQLHYHERIHTGEKPYKCNQ--CDKAYTRHSHLQMHKTTHTG-- 307

  Fly   332 SRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIE 396
             .|:..|..|||.|.:...|:.| .|.|.|||||:|..|.:.|.....     |:||:...|..:
Mouse   308 -EKTYKCNQCGKAFAYHSYLQVH-KRIHTGEKPYECNQCGKAFVCPGH-----LQRHKRTHTGEK 365

  Fly   397 RSECMLCRQPFSSEPDLIHHMSAEHLQRP-----GAPIIANNKRVLQQKRERQYSGLFQCGSCSQ 456
            ..||..|.:.|:....|..|......::|     .....|....:...||.......::|..|.:
Mouse   366 PYECNQCGKAFTYHGHLQIHKRTHTGEKPYECDQCGKAFAYPGYLQVHKRTHTGEKPYECDQCGK 430

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .|.....|:.|...|: :::|:.|..|.|.|.....::.|.:||..|||..|:.||||||.:.||
Mouse   431 AFASHGYLQVHKRTHT-REKPYECDQCGKAFASHGYLQVHKRTHTGEKPYECNQCGKAFAGQNVL 494

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            .:|:.:| ..||.:|||.||:|:.|...|::|:.||||:..|:|..|.:.|.:|.:|:.| ::.|
Mouse   495 KRHKRTH-TGEKPYKCNECGKAFAFNTKLQIHKTTHTGEKSYECKQCSKSFASHAQLQYH-ERIH 557

  Fly   587 AASQPHSADQ 596
            ...:|:..:|
Mouse   558 TGEKPYKCNQ 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/322 (28%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Gm35315	XP_011247932.1	C2H2 Zn finger	565..585	CDD:275368	1/3 (33%)
		KRAB	21..61	CDD:366587
		C2H2 Zn finger	121..137	CDD:275368	4/15 (27%)
		COG5048	141..546	CDD:227381	123/417 (29%)
		C2H2 Zn finger	145..165	CDD:275368	2/19 (11%)
		C2H2 Zn finger	173..193	CDD:275368	2/19 (11%)
		C2H2 Zn finger	201..221	CDD:275368	4/19 (21%)
		C2H2 Zn finger	229..249	CDD:275368	8/19 (42%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..305	CDD:275368	5/21 (24%)
		C2H2 Zn finger	313..333	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..361	CDD:275368	6/24 (25%)
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..417	CDD:275368	3/19 (16%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..473	CDD:275368	5/19 (26%)
		C2H2 Zn finger	481..501	CDD:275368	10/19 (53%)
		C2H2 Zn finger	509..529	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/20 (30%)
		zf-H2C2_2	550..574	CDD:372612	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910