DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp764

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006230431.1	Gene:	Zfp764 / 102553866	RGDID:	7540019	Length:	461	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	117/475 - (24%)
Similarity:	181/475 - (38%)	Gaps:	124/475 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LEPAEEHQETETTKPT-----------------TTVSAETQ---PNNTASDPIEIFVDAVDIDEA 153
            |:|||.....|..:.|                 ..|..||:   |.  |.|| |:.:...::...
  Rat    39 LQPAERALYREVMRETYGLLGSFGIRGAKPALICWVEEETELWGPR--AQDP-EVAMCKTEVHSD 100

  Fly   154 EEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQP 218
            ..:||:..:.::..|.::...:.|:.|.:...|:|.      ..:|      ||.:  |.||:|
  Rat   101 CRQEEKRRKPREETEAIQRTFSTEAGPKEPCPSFAA------SPSY------LELL--SKDPQQ- 150

  Fly   219 YNCPECEARFQDAASRTVHLKSS--HVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCE 281
                         ...||.|..:  ..:::|.|.||||.:..:..|..|:..:..|..|:|:.|.
  Rat   151 -------------GQPTVPLHDTVLKADQRHGCHVCGKSFTRQSKLVEHLYTHTGEKPFQCSECN 202

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|....||:.|...|..:|..                  |               |..|||:|.
  Rat   203 KCFGRASSLSMHRAIHRRERPH------------------C---------------CPDCGKSFT 234

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSE----CMLCRQPF 407
            ...||..|:| .|.||||::|.:|.:.|:..:.     |..||    ||.|.|    |..|.:.|
  Rat   235 QRSTLVAHMY-THTGEKPFRCPDCNKSFSWPSS-----LSTHR----AIHRGERPHCCPDCGRAF 289

  Fly   408 SSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHS 472
            :....||.|:.....::|                       :.|..|.:.|:..|.|..|..|..
  Rat   290 THRSGLITHLRVHTGEKP-----------------------YCCADCGRCFSQSSGLSEHQRVVH 331

  Fly   473 EKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKC 537
            ....|.:|.||.:.|.||..::.|::||..|||..|..||:.|.....:..||.:|.. |:.:.|
  Rat   332 SGMTPFSCTHCGRAFARAAYLRCHMRTHTGEKPYSCPDCGRCFRQGSDMAAHRRTHSG-ERPYPC 395

  Fly   538 NVCGRAYLFEKSLRLHQRTH 557
            ..|||.:..:.::..||..|
  Rat   396 PQCGRGFPTKSAMTKHQWVH 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	81/315 (26%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	1/21 (5%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp764	XP_006230431.1	KRAB	22..81	CDD:214630	9/41 (22%)
		KRAB	22..60	CDD:279668	6/20 (30%)
		C2H2 Zn finger	170..190	CDD:275368	7/19 (37%)
		zf-H2C2_2	183..207	CDD:290200	8/23 (35%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		zf-H2C2_2	210..235	CDD:290200	11/57 (19%)
		COG5048	<223..383	CDD:227381	56/225 (25%)
		C2H2 Zn finger	226..246	CDD:275368	9/20 (45%)
		zf-H2C2_2	239..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	254..274	CDD:275368	7/28 (25%)
		zf-H2C2_2	266..291	CDD:290200	10/33 (30%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		zf-H2C2_2	295..319	CDD:290200	7/46 (15%)
		C2H2 Zn finger	310..329	CDD:275368	6/18 (33%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		zf-H2C2_2	351..376	CDD:290200	10/24 (42%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		zf-H2C2_2	383..402	CDD:290200	8/19 (42%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100