DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8301 and Zfp28

DIOPT Version :9

Sequence 1:NP_649915.1 Gene:CG8301 / 41160 FlyBaseID:FBgn0037717 Length:607 Species:Drosophila melanogaster
Sequence 2:XP_006228267.1 Gene:Zfp28 / 102548693 RGDID:7679103 Length:851 Species:Rattus norvegicus


Alignment Length:576 Identity:150/576 - (26%)
Similarity:231/576 - (40%) Gaps:108/576 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 TKFCSINAF--RLACQEAQLKL----SHIYDKIDASSLEDDEI-----GQEDLEPAEEHQETETT 121
            |:..|.|.|  :.:.||||..|    ||. .::..|:...:..     |..|.|...|....:| 
  Rat   280 TETASTNLFSGQQSVQEAQDSLPRQDSHA-GRVTGSTWSTERACSAFRGDRDSECVFERNGQDT- 342

  Fly   122 KPTTTVSAETQPNNTASDPIEIFVDAVDIDEAE--EEEEEEEQQQQYDEEVEEPITDESAPPQLT 184
                  :.|:| |...|:.    .|.|.::...  .....||:....|       :.:::.|..|
  Rat   343 ------AFESQ-NRAFSEG----RDGVCLNSGRWFHLNSSEERSHNCD-------SGKTSLPNPT 389

  Fly   185 I-----------SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHL 238
            :           .:.|..|   ::.:.....|..| ...|..|:||.|.||...|.|.:|...|.
  Rat   390 VIKETRIYSGKKLFKCNEC---KKTFTQSSSLTVH-QRIHTGEKPYKCNECGKAFSDGSSFARHQ 450

  Fly   239 KSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQ 302
            :....:|.:.|..|||.:....:|..|...||: |..|:|..|.|.|.....||.|.:.|..::.
  Rat   451 RCHTGKKPYECLECGKAFIQNTSLVRHWRYYHTGEKPFDCIDCGKAFSDHIGLNQHRRIHTGEKP 515

  Fly   303 FKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKC 367
            :.|  ..|.:.|.....|..|:..|:|   .|...|..|.|.|.|..:|..| .|.|.||||:||
  Rat   516 YTC--DVCHKSFRYGSSLTVHQRIHTG---EKPYECEICRKAFSHHASLTQH-QRVHSGEKPFKC 574

  Fly   368 ANCTEVF------ASYAEKRIH-------------------MLERHRENLTAIERSECMLCRQPF 407
            ..|.:.|      ||:.  |||                   .|..|:...|..:..||.:|.:.|
  Rat   575 KECGKAFRQNIHLASHL--RIHTGEKPFECGDCGKSFSISSQLATHQRIHTGEKPYECKVCNKAF 637

  Fly   408 SSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHS 472
            :.:..|..|......::|                       ::|..|.:.|:..:.|.:|..||:
  Rat   638 TQKAHLAQHQKTHTGEKP-----------------------YECKECGKAFSQTTHLIQHQRVHT 679

  Fly   473 EKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKC 537
             .::|:.|..|.|.|........|.:.|..::|..|..|||||..|..|..||..| ..||.::|
  Rat   680 -GEKPYKCLECGKAFGDNSSCTQHQRLHTGQRPYECVECGKAFKTKSSLICHRRCH-TGEKPYEC 742

  Fly   538 NVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHS 593
            :.||:|:...:||.:|||.|:||..|:|..|::.|:....|..| ::.||..:.::
  Rat   743 SACGKAFSHRQSLSVHQRIHSGKKPYECKECRKTFIQIGHLNQH-KRVHAGERTYN 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8301NP_649915.1 zf-AD 3..87 CDD:285071 8/20 (40%)
COG5048 198..>508 CDD:227381 87/335 (26%)
C2H2 Zn finger 221..241 CDD:275368 7/19 (37%)
C2H2 Zn finger 249..269 CDD:275368 6/19 (32%)
C2H2 Zn finger 277..297 CDD:275368 7/19 (37%)
C2H2 Zn finger 305..327 CDD:275368 5/21 (24%)
C2H2 Zn finger 338..359 CDD:275368 8/20 (40%)
C2H2 Zn finger 367..384 CDD:275368 8/41 (20%)
C2H2 Zn finger 400..420 CDD:275368 5/19 (26%)
C2H2 Zn finger 451..471 CDD:275368 5/19 (26%)
C2H2 Zn finger 480..500 CDD:275368 5/19 (26%)
C2H2 Zn finger 508..528 CDD:275368 10/19 (53%)
C2H2 Zn finger 537..557 CDD:275368 9/19 (47%)
C2H2 Zn finger 565..582 CDD:275368 4/16 (25%)
Zfp28XP_006228267.1 KRAB 102..162 CDD:214630
KRAB 102..141 CDD:279668
KRAB <238..277 CDD:214630
COG5048 367..789 CDD:227381 125/466 (27%)
zf-C2H2 403..425 CDD:278523 4/25 (16%)
C2H2 Zn finger 405..425 CDD:275368 4/23 (17%)
zf-H2C2_2 417..441 CDD:290200 9/24 (38%)
C2H2 Zn finger 433..453 CDD:275368 7/19 (37%)
zf-H2C2_2 445..470 CDD:290200 7/24 (29%)
C2H2 Zn finger 461..479 CDD:275368 6/17 (35%)
C2H2 Zn finger 490..510 CDD:275368 7/19 (37%)
zf-H2C2_2 503..527 CDD:290200 7/25 (28%)
C2H2 Zn finger 518..538 CDD:275368 5/21 (24%)
zf-H2C2_2 530..555 CDD:290200 9/27 (33%)
C2H2 Zn finger 546..566 CDD:275368 8/20 (40%)
zf-H2C2_2 558..583 CDD:290200 12/25 (48%)
C2H2 Zn finger 574..594 CDD:275368 6/21 (29%)
zf-H2C2_2 586..610 CDD:290200 5/25 (20%)
C2H2 Zn finger 602..622 CDD:275368 2/19 (11%)
zf-H2C2_2 615..639 CDD:290200 7/23 (30%)
C2H2 Zn finger 630..650 CDD:275368 5/19 (26%)
zf-H2C2_2 642..667 CDD:290200 6/47 (13%)
C2H2 Zn finger 658..678 CDD:275368 5/19 (26%)
zf-H2C2_2 670..693 CDD:290200 8/23 (35%)
C2H2 Zn finger 686..706 CDD:275368 5/19 (26%)
zf-H2C2_2 701..723 CDD:290200 9/21 (43%)
C2H2 Zn finger 714..734 CDD:275368 10/19 (53%)
zf-H2C2_2 726..751 CDD:290200 10/25 (40%)
C2H2 Zn finger 742..762 CDD:275368 9/19 (47%)
zf-H2C2_2 754..779 CDD:290200 12/24 (50%)
C2H2 Zn finger 770..790 CDD:275368 5/20 (25%)
C2H2 Zn finger 798..818 CDD:275368 150/576 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24377
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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