DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and LOC101735222

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_004915678.2	Gene:	LOC101735222 / 101735222	-ID:	-	Length:	756	Species:	Xenopus tropicalis

Alignment Length:	702	Identity:	169/702 - (24%)
Similarity:	261/702 - (37%)	Gaps:	162/702 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDCFT-------------KFC 71
            |.....::||... ||....::|..||.:  ::.|......:|..|..|             |..
Frog    11 SRQETVMELHIKK-WPGMEKRLRSVFAKY--RLVPYGSKTSRIRGDVSTESTKSQKQTHQSNKSV 72

  Fly    72 SINAFRLA---------------CQEAQLKLSHIYDKIDASSLEDDEIGQEDLE----------- 110
            |...|...               |.:..:...|:.......|.|....|.|..|
Frog    73 SCKEFGRTSNQEQTGEKGFTCGHCGKIYMDEHHLSVHFQLHSAEKPLAGTETAETTMGKSNVRDL 137

  Fly   111 PA----------------EEHQETET---------------TKPTTTVSAETQPNNTASDPIEIF 144
            ||                ||||.|.|               :||...   |.|..:|
Frog   138 PAFPCPECERSFSSKPRLEEHQRTHTEVKLHECTEYERSFSSKPRLD---EHQRTHT-------- 191

  Fly   145 VDAVDIDEAEEEEE--------EEEQQQQYDEEVEEPITDE---SAPPQL---------TISYAC 189
              .|.:.|..|.|.        :|.|:...:.::.|.:..|   |:.|:|         ...:.|
Frog   192 --EVKLHECTECERSFSSKPRLDEHQRTHTEVKLHECMECERSFSSKPRLDKHQRTHTEVKLHEC 254

  Fly   190 KFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGK 254
            ..|   :.::..:..|.|| ..:|...:.:.|.|||..|........|.::....|.|.|..|.:
Frog   255 TEC---ERSFSSKPRLDEH-QRTHTEVKLHECTECERSFSSKPRLDEHQRTHTEVKLHECTECER 315

  Fly   255 KYGDRHNLRHHVEKYHSETDF-ECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQR 318
            .:..:..|..| ::.|:|... ||..||:.|.::..|:.|.:.|...:..:|  :.|||.|.|:.
Frog   316 SFSSKPRLDEH-QRTHTEVKLHECTECERSFSSKPRLDKHQRTHTEVKLHEC--TECERSFSSKP 377

  Fly   319 HLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFAS------- 376
            .|..|:.||:..   |...|..|.::|.....|..| .|.|...|.::|..|...|:|
Frog   378 RLDEHQRTHTEV---KLHECTECERSFSSKPRLDEH-QRTHTEVKLHECTECERSFSSKPRLDEH 438

  Fly   377 ---YAEKRIH-------------MLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP 425
               :.|.::|             .|::|:...|.::..||..|.:.|||:|.|..|      ||.
Frog   439 QRTHTEVKLHECTECERSFSSKPRLDKHQRTHTEVKLHECTECERSFSSKPRLDEH------QRT 497

  Fly   426 GAPI-----------IANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHA 479
            ...:           .::..|:.:.:|......|.:|..|.:.|:.|..|:.|...|:|. :.|.
Frog   498 HTEVKLHECTECERSFSSKPRLDEHQRTHTEVKLHECTECERSFSSKPRLDEHQRTHTEV-KLHE 561

  Fly   480 CPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |..|.|.|:|.|.:|.|...|...|...||.|||.|..:..|:.|||||.. ||.|.|:.||:::
Frog   562 CTECGKSFQRKQHLKAHYLMHTGVKAFSCDECGKRFKQRNGLSTHRLSHSG-EKPFVCSECGKSF 625

  Fly   545 LFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ..:..|..|...|||:| :.|..|:|.|.:...||.| |..|...:|:...:
Frog   626 RAKTDLNYHLNIHTGRT-FPCTECEESFPSQKHLKRH-QMIHTGEKPYDCTE 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	16/94 (17%)
		COG5048	198..>508	CDD:227381	87/344 (25%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	6/39 (15%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
LOC101735222	XP_004915678.2	C2H2 Zn finger	93..113	CDD:275368	2/19 (11%)
		C2H2 Zn finger	142..162	CDD:275368	4/19 (21%)
		C2H2 Zn finger	170..190	CDD:275368	4/22 (18%)
		C2H2 Zn finger	198..218	CDD:275368	4/19 (21%)
		COG5048	222..634	CDD:227381	113/430 (26%)
		C2H2 Zn finger	226..246	CDD:275368	4/19 (21%)
		C2H2 Zn finger	254..274	CDD:275368	5/23 (22%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..330	CDD:275368	4/20 (20%)
		C2H2 Zn finger	338..358	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	8/21 (38%)
		C2H2 Zn finger	394..414	CDD:275368	6/20 (30%)
		C2H2 Zn finger	422..442	CDD:275368	4/19 (21%)
		C2H2 Zn finger	450..470	CDD:275368	2/19 (11%)
		C2H2 Zn finger	478..498	CDD:275368	10/25 (40%)
		C2H2 Zn finger	506..526	CDD:275368	2/19 (11%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		C2H2 Zn finger	562..582	CDD:275368	8/19 (42%)
		C2H2 Zn finger	590..610	CDD:275368	10/19 (53%)
		C2H2 Zn finger	618..638	CDD:275368	5/19 (26%)
		C2H2 Zn finger	645..665	CDD:275368	8/20 (40%)
		zf-H2C2_2	657..682	CDD:404364	6/20 (30%)
		C2H2 Zn finger	673..693	CDD:275368	0/3 (0%)
		C2H2 Zn finger	701..721	CDD:275368
		C2H2 Zn finger	729..749	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100