DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF256

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_005764.2	Gene:	ZNF256 / 10172	HGNCID:	13049	Length:	627	Species:	Homo sapiens

Alignment Length:	415	Identity:	122/415 - (29%)
Similarity:	189/415 - (45%)	Gaps:	57/415 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACG 250
            ||.|..|   .:::.....|.:|:.. |..|:||.|.||...::.::|...|.:.....:.|.|.
Human   238 SYMCSEC---GKSFSTSCSLSDHLRV-HTSEKPYTCGECGKSYRQSSSLITHRRIHTGVRPHQCD 298

  Fly   251 VCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFI 315
            .|||.:..:::|..|...:..|..::|:.|.|.|....||..|.:.|...|.::|  |.|.:.||
Human   299 ECGKLFNRKYDLLIHQRVHTGERPYKCSECGKSFSHSSSLITHQRIHTGMRPYEC--SECGKSFI 361

  Fly   316 SQRHLMCHEATHSGTSSRKSEHCGFCGKTF---IHL-KTLRWHIYRQHGGEKPYKCANCTEVFA- 375
            ....|:.|:..|:||   :...|..|||:|   .|| |..|.||     ||.||:|:.|.::|.
Human   362 HSSSLITHQRVHTGT---RPYMCSECGKSFSQSCHLIKHRRLHI-----GEGPYECSECGKLFTY 418

  Fly   376 ---SYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVL 437
               .:..:|:|         |.:...||..|.:.||.:.|||.|......:||
Human   419 RSRFFQHQRVH---------TGVRSHECHECGKLFSRKFDLIVHERVHTGERP------------ 462

  Fly   438 QQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEK 502
                       ::|..|.:.|..||.|..|..||:.. ||:.|..|.|.|..:..:..|.:.|..
Human   463 -----------YECSECGKSFTCKSYLISHWKVHTGA-RPYECGECGKSFTHSSTLLQHQRVHTG 515

  Fly   503 EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDL 567
            |:|..|:.|||.|:....|.:||.|| ..|:.::|:.|.:::....||..|:|.|||:..|:|..
Human   516 ERPYECNECGKFFSQSSSLIRHRRSH-TGERPYECSECWKSFSNHSSLVKHRRVHTGERPYECSE 579

  Fly   568 CQERFVTHIKLKTHMQKAHAASQPH 592
            |.:.|.....|..| |:.|:..:|:
Human   580 CGKSFSQSSNLTNH-QRIHSGERPY 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/317 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	11/24 (46%)
		C2H2 Zn finger	367..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF256	NP_005764.2	KRAB	14..54	CDD:366587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76
		C2H2 Zn finger	215..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368	4/23 (17%)
		C2H2 Zn finger	269..289	CDD:275368	5/19 (26%)
		COG5048	293..626	CDD:227381	107/356 (30%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		C2H2 Zn finger	325..345	CDD:275368	7/19 (37%)
		C2H2 Zn finger	353..373	CDD:275368	7/21 (33%)
		C2H2 Zn finger	381..401	CDD:275368	9/19 (47%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	5/19 (26%)
		C2H2 Zn finger	521..541	CDD:275368	8/19 (42%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	6/20 (30%)
		C2H2 Zn finger	605..625	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100