DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and LOC100912787

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006228824.1	Gene:	LOC100912787 / 100912787	RGDID:	6485475	Length:	562	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	121/470 - (25%)
Similarity:	186/470 - (39%)	Gaps:	79/470 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 DEAEEEEEEEEQQQQYDEEV----EEPITDESA-------PPQLTISYACKFCLRPQENYQLQQL 204
            |...:.:.::.|.|:|.|::    |..||:...       ..:..|...|:..|.....:.|.||
  Rat   120 DREGKNQFQKHQSQEYCEQLAVAYERMITENQVSNHQRLNAGERAIGIQCEKALSVGSVHGLHQL 184

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRT----VHLKSSHVEKQHACGVCGKKYGDRHNLRHH 265
                   :|...:.....||...|.....||    |....:....:.:.|..|...|.....|.|
  Rat   185 -------THPGNKLNKNKECGETFVPGWERTHGQQVPCHKTPQRGKDSRGPFGLPSGMPDLQRDH 242

  Fly   266 VEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGT 330
            .    .|..::|..|.|.|..:.:|..|.:.|..:|.:.|.  ||.:.|..:.||..|:..|:|
  Rat   243 T----GEKSYDCKECGKSFTLKSNLTRHRRIHTGERPYMCH--GCGKAFTQKSHLTSHQKVHTG- 300

  Fly   331 SSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAI 395
              :::..|..|||.|                       ||.....|:.....|.::..|:..
  Rat   301 --KRAYVCRVCGKAF-----------------------NCDSSLTSHQNSHYHEVDAGRKVY--- 337

  Fly   396 ERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPI-IANNKRVLQQKRERQYSGL--FQC 451
               ||.:|.:.|....||.||......:||      |.|. ..::.||    ..|.::|:  :.|
  Rat   338 ---ECKICDKEFGCYSDLSHHQKIHAGERPFKCKHCGKPFRFHSHLRV----HTRIHTGVRSYDC 395

  Fly   452 GSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFA 516
            ..|.:.|.::|.|.||..||: .:||:||..|.|.|.:...:..|.|.|..||..||.||||||:
  Rat   396 KECGKSFTLRSNLTRHHRVHT-GERPYACHGCGKAFTQKSHLTSHQKIHTGEKAYVCGVCGKAFS 459

  Fly   517 LKYVLTQHRLSHEVL----EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIK 577
            ....||.|:..|..:    :|.::|..||:.:....:|..||:.|.|...:||..|.:.|.....
  Rat   460 RGSSLTNHQNIHYYVVNAGKKVYECKECGKGFGCLSNLSRHQKIHAGDKPFKCRDCGKDFGQRAH 524

  Fly   578 LKTHMQKAHAASQPH 592
            |..| |:.|....|:
  Rat   525 LTKH-QRVHTGESPY 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	80/322 (25%)
		C2H2 Zn finger	221..241	CDD:275368	6/23 (26%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	5/20 (25%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
LOC100912787	XP_006228824.1	KRAB	6..66	CDD:214630
		KRAB	6..45	CDD:279668
		COG5048	<246..428	CDD:227381	57/220 (26%)
		zf-C2H2	248..270	CDD:278523	6/21 (29%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		zf-H2C2_2	262..287	CDD:290200	8/26 (31%)
		C2H2 Zn finger	278..298	CDD:275368	7/21 (33%)
		zf-H2C2_2	290..315	CDD:290200	10/50 (20%)
		C2H2 Zn finger	306..326	CDD:275368	8/42 (19%)
		C2H2 Zn finger	339..359	CDD:275370	7/19 (37%)
		zf-C2H2	365..387	CDD:278523	5/25 (20%)
		C2H2 Zn finger	367..387	CDD:275368	5/23 (22%)
		zf-H2C2_2	379..403	CDD:290200	6/27 (22%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		zf-H2C2_2	407..432	CDD:290200	12/25 (48%)
		COG5048	419..>476	CDD:227381	24/56 (43%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		zf-H2C2_2	435..460	CDD:290200	13/24 (54%)
		C2H2 Zn finger	451..471	CDD:275368	10/19 (53%)
		zf-H2C2_2	496..519	CDD:290200	8/22 (36%)
		C2H2 Zn finger	512..532	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100