DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp182

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038956501.1	Gene:	Zfp182 / 100911831	RGDID:	6490591	Length:	640	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	158/601 - (26%)
Similarity:	263/601 - (43%)	Gaps:	87/601 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LDLHHPN-------CWP-SEMAQIRLQFANWN---------LKIS-PNDGLPQKICSDCFTKFCS 72
            |::..||       .|. .|:.|:..||...:         :::. |||.:..| .....|:|.
  Rat    80 LEVEEPNPEDVEIPVWSFPEVCQVNEQFERQHQDKQDKYLLMQVGFPNDKIITK-SGQNHTEFG- 142

  Fly    73 INAFRLACQ-EAQLKLSHIYDKIDASSLEDDEI-------GQEDLEPAEEHQETETTKPTTTVSA 129
             |||.::.. ...::.||.::....:.:::..:       .:.|...|:....||...|
  Rat   143 -NAFHVSTSLVVPMQRSHQFESFGNNMVDNFNLLTRSSTENKHDTGCAKFFFHTEYANP------ 200

  Fly   130 ETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLR 194
                 |....|...            :|.|:..:|:....:.:.|.:...|      :.|..|
  Rat   201 -----NFMMKPYGY------------KEYEKTLRQKKGLSLHQRIKNGERP------FECTAC-- 240

  Fly   195 PQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDR 259
             |:.:..:..|:.|.. :|..|:|:.|.||...|...:...:||::...|:..||..|||.:.::
  Rat   241 -QKTFSKKSHLIVHWR-THTGEKPFECSECGKAFSQKSQLIIHLRTHTGERPFACPECGKAFREK 303

  Fly   260 HNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHE 324
            ..:..|...:..|..:||..|.|.|..:.:|..|.|.|..::.::|  :.|...||.:..|:.|.
  Rat   304 STVIIHYRTHTGEKPYECNECGKAFTQKSNLIVHQKTHTGEKTYEC--TKCGESFIQKLDLIIHH 366

  Fly   325 ATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHR 389
            :||:|   :|...|..|.|||....||..| .|.|.||||:||..|.:   |:.||...::  |:
  Rat   367 STHTG---KKPHECNECKKTFSDKSTLVIH-QRTHTGEKPHKCIECGK---SFNEKSTLIV--HQ 422

  Fly   390 ENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANN-KRVLQQK-----RERQYSG- 447
            ...|..:..||.:|.:.|:.:.:|..|......::   |...|. ::...||     .:|.::|
  Rat   423 RTHTGEKPYECDVCGKTFTQKSNLGVHQRTHSGEK---PFECNECEKAFSQKSYLMLHQRGHTGE 484

  Fly   448 -LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
             .::|..|.:.|:.||.|..|...|:| ::|:.|..|.|.|:....:..|.:.|..|||..|.||
  Rat   485 KPYECNECEKAFSQKSYLIIHQRTHTE-EKPYKCNECGKAFREKSKLIIHQRIHTGEKPYECLVC 548

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHI 576
            .|||:.|..|..|:.:| ..||.::|..||:|:..:.:..:|||||||:..|||..|.:.|....
  Rat   549 WKAFSQKSQLIIHQRTH-TGEKPYECTECGKAFREKSTFTVHQRTHTGEKPYKCTECGKAFTQKS 612

  Fly   577 KLKTHMQKAHAASQPH 592
            .|..| |:.|...:.|
  Rat   613 NLIVH-QRTHTGKKAH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/79 (22%)
		COG5048	198..>508	CDD:227381	91/317 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp182	XP_038956501.1	KRAB	8..84	CDD:214630	1/3 (33%)
		COG5048	233..622	CDD:227381	126/415 (30%)
		C2H2 Zn finger	237..257	CDD:275368	5/23 (22%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		C2H2 Zn finger	349..369	CDD:275368	6/21 (29%)
		C2H2 Zn finger	377..397	CDD:275368	9/20 (45%)
		C2H2 Zn finger	405..425	CDD:275368	6/24 (25%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	5/19 (26%)
		C2H2 Zn finger	545..565	CDD:275368	9/19 (47%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	601..621	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100