DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and LOC100910046

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038956767.1	Gene:	LOC100910046 / 100910046	RGDID:	6500398	Length:	668	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	153/565 - (27%)
Similarity:	226/565 - (40%)	Gaps:	81/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KISPNDGLPQKICS----------DCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIG 105
            |.:..||.|...|.          :|  |.|. .||||..|..:.:.||..:|    ..:.:|.|
  Rat   143 KSNNKDGTPPYTCQALAHNVERAYEC--KECG-KAFRLPQQLTRHQKSHSGEK----PFKCNECG 200

  Fly   106 QEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEV 170
            :....|.       ..|...|:       :|...|.|.             ||..:........|
  Rat   201 KAFHLPG-------LLKYHKTI-------HTGEKPFEC-------------EECGKSFNCVSHLV 238

  Fly   171 EEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRT 235
            |.........|     |.|..|   .:.::....|::| ...|..::|:.|.||...|......|
  Rat   239 EHRTIHAGVKP-----YECNDC---GKAFKRHSYLMQH-QKIHSGDKPFQCKECGKAFTVLPQLT 294

  Fly   236 VHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPD 300
            .| :::|..::..|..|||.:.....|..|...:..|..|||.:|.|.|..:..||.|.|.|..:
  Rat   295 QH-QNTHTSEKFECKQCGKIFSGGFYLVRHQSIHTGEKPFECNVCGKAFRLQVYLNEHQKTHTDE 358

  Fly   301 RQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPY 365
            :.|||:.  ||..|..:..|..|:..|:..   |...|..|||.|........| ...|.|:||:
  Rat   359 KPFKCKL--CESAFRRKYQLSEHQKIHTNV---KPYQCKDCGKFFRRRSNFTEH-QSIHTGKKPF 417

  Fly   366 KCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP----- 425
            :|..|.:||    ...||:: ||:...:.....||..|.:.|.....|.:|.:....|.|
  Rat   418 ECKQCGKVF----RLNIHLI-RHQSFHSGKRPFECNECGKGFHFSSQLNYHKTIHTGQTPFECEK 477

  Fly   426 -GAPIIANNKRVLQQKRERQYSGL---FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKR 486
             |...    |||......|.....   ::|..|.:.||.:|.|.:|..:|| .:||..|..|.|.
  Rat   478 CGKSF----KRVCSLLEHRVIHAAVKPYECSECGKTFNRRSNLVQHQKIHS-GERPFECKECGKG 537

  Fly   487 FKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLR 551
            |.....:..|...|..||...|:.||.||.|:|.||||:..|..: |.|:|..||:.::...:||
  Rat   538 FTVLAQLTRHQTIHTGEKSFECEQCGSAFRLQYQLTQHQRIHNDV-KPFECKECGKGFVRGTALR 601

  Fly   552 LHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :|:|.|||:..::|..|.|.|..|.:...| .:.|...:|:..::
  Rat   602 IHERIHTGERPFQCKECGEGFQYHYQFLGH-SRTHTGKKPYECNE 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/45 (29%)
		COG5048	198..>508	CDD:227381	89/318 (28%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
LOC100910046	XP_038956767.1	KRAB	14..75	CDD:214630
		COG5048	<168..323	CDD:227381	43/198 (22%)
		C2H2 Zn finger	168..188	CDD:275368	8/22 (36%)
		C2H2 Zn finger	196..216	CDD:275368	5/33 (15%)
		C2H2 Zn finger	224..244	CDD:275368	4/32 (13%)
		COG5048	248..653	CDD:227381	125/426 (29%)
		C2H2 Zn finger	252..272	CDD:275368	4/23 (17%)
		C2H2 Zn finger	280..300	CDD:275368	6/20 (30%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/21 (29%)
		C2H2 Zn finger	391..411	CDD:275368	6/20 (30%)
		C2H2 Zn finger	419..439	CDD:275368	8/24 (33%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	5/23 (22%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275368	11/19 (58%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..635	CDD:275368	6/20 (30%)
		C2H2 Zn finger	643..663	CDD:275368	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100