DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and LOC100909688

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038959495.1	Gene:	LOC100909688 / 100909688	RGDID:	6502425	Length:	541	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	137/528 - (25%)
Similarity:	223/528 - (42%)	Gaps:	85/528 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 IEIFVDA------------VDIDEAEEEEE--EEEQQQQYDEEVEE------------------P 173
            |::|:.|            |.||.:.||.|  |..|...|.|.:.|                  .
  Rat     3 IQVFIIAKELTQDLLSFTDVAIDFSPEECECLEPAQWNLYKEVMLENYSNLLFLGLAFSKPYLVT 67

  Fly   174 ITDESAPPQL------------TISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEA 226
            ..::|:.|..            :.::.||.|   .:.:....:|::| ...|..|:||.|.||..
  Rat    68 FLEQSSDPWRVRRKASAAIHLGSKAHKCKEC---GKAFDRNSVLIQH-QRIHTGERPYKCEECGM 128

  Fly   227 RFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLN 291
            .|......:.|.:....||.:.|..|||.:....||..|.:.:..|..::|..|.|.|.....|:
  Rat   129 AFTVRCILSKHQRIHTGEKPYKCKECGKAFSCSSNLHQHQQIHREEKLYKCGECGKAFSCSSYLH 193

  Fly   292 YHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIY 356
            .|.:.|...:.:||:.  |.:.|....:|:.|:..|:|   .|...||.|||.|....|...| .
  Rat   194 RHQRIHTGMKPYKCKE--CGKAFNCSANLIYHQRIHTG---EKPYKCGECGKAFTIYSTFMNH-Q 252

  Fly   357 RQHGGEKPYKCANCTEVFAS----YAEKRIHM-------------------LERHRENLTAIERS 398
            |.|.|||||:|.:|.:.|.:    ...:|||.                   |::|:...|..:..
  Rat   253 RTHSGEKPYECKDCGKAFTNCYNLIQHQRIHTGEKPYACEECGKSFNYSSHLKQHKRIHTGEKPY 317

  Fly   399 ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPII---ANNKRVLQQKRERQYSG--LFQCGSCSQRF 458
            :|.:|.:.|:....|:.|......::|....:   |.:......|.:|.::|  .::|..|.:.|
  Rat   318 KCEVCGKAFNCSDYLVKHQRIHTGEKPYKCEVCGKAFSFSTYLHKHQRIHTGEKRYRCEECGRAF 382

  Fly   459 NMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQ 523
            ...|.|..|..||: .::|:.|..|.|.|.....:..|.:.|.:|:|..||.|||.|.:....::
  Rat   383 TNYSGLIVHRRVHT-GEKPYKCEECGKAFSVHTSLSKHQRIHTREQPYKCDECGKRFNVHSAFSK 446

  Fly   524 HRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAA 588
            |::.| ..||.:||..|.:.:.:...|..|:|.|||:..|||::|.:.|.:...||.|. :.|..
  Rat   447 HQIMH-TREKPYKCKHCDKTFKYPSPLVQHERIHTGERPYKCEVCGKAFTSSSNLKYHW-RLHTG 509

  Fly   589 SQPHSADQ 596
            .:|:..:|
  Rat   510 EKPYKCEQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/337 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
LOC100909688	XP_038959495.1	KRAB	17..76	CDD:214630	12/58 (21%)
		C2H2 Zn finger	95..115	CDD:275368	5/23 (22%)
		COG5048	119..540	CDD:227381	114/408 (28%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	151..171	CDD:275368	7/19 (37%)
		C2H2 Zn finger	179..199	CDD:275368	6/19 (32%)
		C2H2 Zn finger	207..227	CDD:275368	5/21 (24%)
		C2H2 Zn finger	235..255	CDD:275368	9/20 (45%)
		C2H2 Zn finger	263..283	CDD:275368	4/19 (21%)
		C2H2 Zn finger	291..311	CDD:275368	2/19 (11%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		C2H2 Zn finger	347..367	CDD:275368	3/19 (16%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		C2H2 Zn finger	487..507	CDD:275368	6/20 (30%)
		C2H2 Zn finger	515..535	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100