DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and si:cabz01032454.3

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_003198589.1	Gene:	si:cabz01032454.3 / 100534979	ZFINID:	ZDB-GENE-161017-73	Length:	499	Species:	Danio rerio

Alignment Length:	497	Identity:	145/497 - (29%)
Similarity:	224/497 - (45%)	Gaps:	68/497 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYD--EEVEEPIT 175
            :|..|....:.|.||..| .|..|     |:.|       .:||.:|..:.::.|  |..::..|
Zfish     5 KEESEDLKIEDTFTVKQE-DPEQT-----ELMV-------LKEETQEMNEMKEKDQIETHQDLTT 56

  Fly   176 DESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKS 240
            ||.:        :||                    .|...:..:.|.:|...|....:..||::.
Zfish    57 DEQS--------SCK--------------------RSPKTKSDFICSQCGKGFNHQPNLIVHMRI 93

  Fly   241 SHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKC 305
            ...|:.::|..|||.:.....|:.|:..:..|..:.|..|.|.|..::|||.|::.|..::.|.|
Zfish    94 HTGERPYSCDQCGKSFSQNEKLKVHMRVHTKERPYTCPQCGKSFTQKESLNVHIRVHTGEKPFPC 158

  Fly   306 RHSGCERLFISQRH-LMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCAN 369
            :|  |.:.| ||.| |..|...|:|   .:...|..|||||.|.:.|..|: ..|.|||.:.|..
Zfish   159 QH--CGKRF-SQLHALKEHVTIHTG---ERPHACTVCGKTFYHKQKLEKHM-TVHTGEKLFDCQQ 216

  Fly   370 CTEVFASYAEKRIHMLERHRENLTAIERSE-CMLCRQPFSSEPDLIHHMSAEHLQRP------GA 427
            |.:.|......||||....::...|.|:.. |..|.:.|:|:.:|.|||.....::|      |.
Zfish   217 CGKRFGQKDSLRIHMKLHTKDKPHAKEKPYICTECDKAFASKSNLNHHMVTHTGEKPFSCDECGK 281

  Fly   428 PIIANNKRVLQQK---RERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKR 489
            ....|:|..:..:   :|:.||    |..|.:.|:....|:.|..||: |:||:.||.|.|.|.:
Zfish   282 SFGQNSKLKVHMRVHTKEKPYS----CDQCGKSFSQNEKLKVHMRVHT-KERPYTCPQCGKSFTQ 341

  Fly   490 AQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQ 554
            .:::|.||:.|..|||..|..|||.|...:||.:|..:| ..||.|.|..|.:.|..::.|::|.
Zfish   342 KENLKVHIRVHTGEKPFPCQECGKRFMQLHVLKEHLRTH-TGEKPFACPQCSKTYCQKQKLKMHM 405

  Fly   555 RTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            ..|..:..:.|..|.:||.....||:|| |.||..:.|:..|
Zfish   406 TVHAKEKLFPCQQCGKRFGYRGSLKSHM-KLHAEDKRHTCSQ 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/320 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	9/22 (41%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
si:cabz01032454.3	XP_003198589.1	COG5048	52..481	CDD:227381	130/437 (30%)
		C2H2 Zn finger	74..94	CDD:275368	5/19 (26%)
		zf-H2C2_2	86..111	CDD:290200	7/24 (29%)
		C2H2 Zn finger	102..122	CDD:275368	6/19 (32%)
		zf-H2C2_2	115..139	CDD:290200	7/23 (30%)
		C2H2 Zn finger	130..150	CDD:275368	8/19 (42%)
		zf-H2C2_2	142..167	CDD:290200	10/27 (37%)
		C2H2 Zn finger	158..178	CDD:275368	9/22 (41%)
		C2H2 Zn finger	186..206	CDD:275368	9/20 (45%)
		C2H2 Zn finger	214..234	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		zf-H2C2_2	260..283	CDD:290200	6/22 (27%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		zf-H2C2_2	289..313	CDD:290200	6/27 (22%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		zf-H2C2_2	317..341	CDD:290200	12/24 (50%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..367	CDD:290200	11/22 (50%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		C2H2 Zn finger	416..436	CDD:275368	9/20 (45%)
		C2H2 Zn finger	444..464	CDD:275368	1/3 (33%)
		C2H2 Zn finger	472..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910