DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and znf853

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_031748869.1	Gene:	znf853 / 100487314	XenbaseID:	XB-GENE-6031115	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	136/550 - (24%)
Similarity:	206/550 - (37%)	Gaps:	140/550 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DLHHPNCWPSEMAQIRLQFANW-------NLKISPND------GLPQKICSDCFTKFCSINAFRL 78
            ||....|:.:|.::|..:.|::       |.:|||.:      |:.::..||     ||||..
Frog   165 DLGGTLCYNNEPSKIGAEGADFCVDGELRNPEISPAEQPPPANGIKEEAASD-----CSINPL-- 222

  Fly    79 ACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEI 143
                                             .|:.|.|:|..|....|..   ||:|.|...:
Frog   223 ---------------------------------TEQIQGTDTPTPIMGCSLN---NNSAEDYRSV 251

  Fly   144 FVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEH 208
            .:        :|||...|.:.|.|..:...|.....|...|.:|.|..|   .:..:.:...|:|
Frog   252 VI--------KEEESSSEGENQSDCSINSQIQGTDTPTPNTETYNCSEC---HKRCKTKAGFLKH 305

  Fly   209 INASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSET 273
             ..:|...:|:.|..||..|:..:...:|.:|...||..:|..|||::....:|..|...:..|.
Frog   306 -QKTHTGVKPFVCSVCEKPFKYQSKLNLHKRSHTGEKPFSCSECGKRFTRHVHLIEHHRTHTGEK 369

  Fly   274 DFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHC 338
            .:.|:.|.|.|........|.:.|..::...|  |.|.:.|.|...|:.|:::|.|   |....|
Frog   370 PYSCSDCGKHFSHSSDFYRHCRIHRLEKLCIC--SQCNKQFTSHSELIVHQSSHVG---RGQYPC 429

  Fly   339 GFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF--ASY--AEKRIHMLERHRENLTAIERSE 399
            ..|||.|:....|:.|: |.|..|:||.|:.|.:.|  :||  ..||||..|:
Frog   430 SECGKHFVSTSQLKIHL-RVHSVERPYSCSECGKCFKYSSYLTVHKRIHTGEK------------ 481

  Fly   400 CMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSAL 464
                  ||:                                          |..|.:.|..::.|
Frog   482 ------PFT------------------------------------------CTECGKGFIDRAYL 498

  Fly   465 ERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
            ..|..:|:.| :|..|..|.|.|.....:|:|.:.|..|||..|..|||.|.....|..|...|
Frog   499 NSHKKIHTGK-KPFTCTECGKCFSEGSRLKFHTRIHTGEKPFSCSECGKCFRNSTSLKFHTRIH- 561

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTG 559
            ..||.|.||.||:.:::...|..|.:.|||
Frog   562 TGEKPFACNECGKYFMYRYQLTAHSQLHTG 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/72 (24%)
		COG5048	198..>508	CDD:227381	77/313 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	8/20 (40%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368
znf853	XP_031748869.1	KRAB_A-box	112..145	CDD:413388
		COG5048	<265..502	CDD:227381	71/306 (23%)
		C2H2 Zn finger	289..309	CDD:275368	4/23 (17%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..421	CDD:275368	7/21 (33%)
		C2H2 Zn finger	429..449	CDD:275368	8/20 (40%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	485..505	CDD:275368	5/19 (26%)
		zf-H2C2_2	497..521	CDD:404364	8/24 (33%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	525..550	CDD:404364	11/24 (46%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	553..576	CDD:404364	10/23 (43%)
		C2H2 Zn finger	569..589	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910