DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and LOC100363372

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_003752039.1	Gene:	LOC100363372 / 100363372	RGDID:	2323171	Length:	659	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	146/581 - (25%)
Similarity:	218/581 - (37%)	Gaps:	157/581 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GSNNSHFLDLHHPNCWPSEMAQI-------RLQFAN----WNLKISPNDGLPQKICSDCFTKFCS 72
            |.:..|.||||.||  .::..:|       |..||:    .||: :|:.|          |:||.
  Rat   195 GKHFKHNLDLHIPN--KNKATKISDQKISHRQDFAHSTSYTNLE-NPHMG----------TEFCE 246

  Fly    73 I---NAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPN 134
            .   ||.|       .|.:|....|..:.        |.|:|.:......|.|..|..|:.
  Rat   247 SQYGNAIR-------FKQAHRQSMIFPTG--------ERLKPCDAFGMNLTQKSYTFTSSR---- 292

  Fly   135 NTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENY 199
                           |...|:..|..:....:.::           |.|:|      |||
  Rat   293 ---------------IHNVEKHPELSKCTNVFTQK-----------PLLSI------CLR----- 320

  Fly   200 QLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRH 264
                        .|..|:.|.|..|...|...:...:|.|:...||.:.|..|||.:....:|..
  Rat   321 ------------FHRDEKLYICTNCGKAFIQNSELKMHEKTHTREKLYTCSECGKSFYQLPSLHR 373

  Fly   265 HVEKYHSETDF-ECALCEKRFYTRKSLNYHMKWHNPDRQFKCR------------------HSG- 309
            | :..|||..| .|:...|.|....:||.|.|.|..:|..||.                  |:|
  Rat   374 H-QTIHSEEKFCSCSEFGKDFSLSSALNIHQKIHTRERHHKCNECGKAFTQKSTLRMHQRIHTGE 437

  Fly   310 -------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKC 367
                   |.:.||.:.||:.|:..|:|   .|...|..|||:|.....|:.| .|.|.|||||.|
  Rat   438 RSYICTKCGQAFIQKAHLIAHQRIHTG---EKPYQCSDCGKSFPSKSQLQMH-KRIHTGEKPYIC 498

  Fly   368 ANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIAN 432
            ..|.:.|.:.:.     |..|:::.|..:...|..|.:.|:...:...|.:....::|..
  Rat   499 TECGKAFTNRSN-----LNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKPHV----- 553

  Fly   433 NKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHI 497
                              |.||.:.|..||.|..|..:|. .::|:.||.|.|.|.:...:|.|.
  Rat   554 ------------------CASCGRAFIQKSQLITHQKIHI-MEKPYKCPDCEKSFFKKPHLKVHQ 599

  Fly   498 KTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            :.|..|||.:|..|||||..:....:|:..| ..:|.:||:.||:.:..:..|.:|:..||
  Rat   600 RIHTGEKPYICAKCGKAFTDRSNFNKHQTVH-TGDKPYKCSECGKGFTQKSVLSIHRNIHT 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	22/81 (27%)
		COG5048	198..>508	CDD:227381	88/336 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	9/47 (19%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368
LOC100363372	XP_003752039.1	KRAB	21..81	CDD:214630
		COG5048	137..481	CDD:227381	88/370 (24%)
		C2H2 Zn finger	305..322	CDD:275368	6/50 (12%)
		COG5048	324..>649	CDD:227381	100/359 (28%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		C2H2 Zn finger	414..434	CDD:275368	1/19 (5%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		C2H2 Zn finger	470..490	CDD:275368	8/20 (40%)
		C2H2 Zn finger	498..518	CDD:275368	5/24 (21%)
		C2H2 Zn finger	526..546	CDD:275368	4/19 (21%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
		C2H2 Zn finger	610..630	CDD:275368	7/19 (37%)
		C2H2 Zn finger	638..658	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100