DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and si:dkey-33c14.6

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_002660736.2	Gene:	si:dkey-33c14.6 / 100333245	ZFINID:	ZDB-GENE-131120-188	Length:	556	Species:	Danio rerio

Alignment Length:	575	Identity:	155/575 - (26%)
Similarity:	237/575 - (41%)	Gaps:	109/575 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEI------FVDAV 148
            |.|.|||   |...:..||.|..|:...||       :..|.|.::...|.|:|      |:..:
Zfish     8 IVDSIDA---ELRRVKDEDAEEEEDRDHTE-------IKEERQESSDGKDCIKINPPGKSFIHKL 62

  Fly   149 DIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACK----------------FCLRPQE 197
            |.:               |..:.......:..|....|:.||                .|::..:
Zfish    63 DSE---------------DPTIIHTSEKPNTCPVCGKSFTCKGSVDVHMRIHTGERPYACIQCGK 112

  Fly   198 NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNL 262
            ::..:..|..|:. :|..|:||.||:||..|...||...|::....:....||.|||.:.....|
Zfish   113 SFTCKGTLTCHVR-THTGEKPYTCPQCEKSFTHKASLRYHMRLHTEDGPFICGQCGKSFAQEEYL 176

  Fly   263 RHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSG------------------ 309
            :|||:.:::...|.|.||.|.|..:.||..|.:.|..::.:.|.|.|
Zfish   177 KHHVKIHYAGKPFTCELCGKGFTCKGSLKIHTRIHTGEKPYTCSHCGKSFTNKGNLKIHANMHTE 241

  Fly   310 --------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYK 366
                    |.:.|..:.:|..|...|:|   .|...|..|||.|.....|:.|: :.|.|||||.
Zfish   242 KSALTCVQCGKSFTHEENLKSHMRIHTG---EKPFSCHQCGKRFARKIILQNHV-KTHSGEKPYT 302

  Fly   367 CANCTEVFA--SYAEK--RIHMLER------------HRENL-------TAIERSECMLCRQPFS 408
            |..|.:.|.  .|.::  |.|..|:            |:.||       |..:.|:|..|.:.|:
Zfish   303 CHQCGKRFTDRGYIKRHMRSHTGEKPFICPQCGKSFTHKGNLKIHIRIHTGEKPSKCPECEKSFT 367

  Fly   409 SEPDLIHHMSAEHLQRPGA-PIIANNKRVL--QQKRERQYSGL--FQCGSCSQRFNMKSALERHA 468
            .:..|..||.....::|.| |:.|...:..  .:...|.:||:  :.|..|.:.|.::.:|..|.
Zfish   368 HKGQLKDHMRIHSGEKPYACPLCAKTFKCKGHLKTHSRTHSGVKPYSCLQCGKSFTVRKSLNVHL 432

  Fly   469 AVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEK 533
            ..|| .::.|.||.|.|||..:...|.|:..|..|:|..||.|||.|.|...|..|...| ..|:
Zfish   433 KYHS-GEKLHECPECGKRFAESNTYKMHLLIHSGERPFSCDKCGKRFILAARLKAHLKLH-TDER 495

  Fly   534 NFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAA 588
            ...|:|||.::....|||.||:|||.:..:.|..|.:.|:....|:.| ::.|.|
Zfish   496 PHVCSVCGESFKLVGSLRSHQKTHTSEKSHVCPECGKAFIRESYLQRH-RRTHTA 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	100/363 (28%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	9/19 (47%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/47 (15%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
si:dkey-33c14.6	XP_002660736.2	C2H2 Zn finger	55..71	CDD:275368	3/30 (10%)
		C2H2 Zn finger	79..99	CDD:275368	4/19 (21%)
		zf-H2C2_2	91..116	CDD:290200	1/24 (4%)
		COG5048	103..503	CDD:227381	114/406 (28%)
		C2H2 Zn finger	107..127	CDD:275368	3/20 (15%)
		zf-H2C2_2	120..144	CDD:290200	11/24 (46%)
		C2H2 Zn finger	135..155	CDD:275368	8/19 (42%)
		C2H2 Zn finger	163..183	CDD:275368	9/19 (47%)
		C2H2 Zn finger	191..211	CDD:275368	8/19 (42%)
		zf-H2C2_2	203..228	CDD:290200	7/24 (29%)
		C2H2 Zn finger	247..267	CDD:275368	4/19 (21%)
		zf-H2C2_2	259..284	CDD:290200	10/27 (37%)
		C2H2 Zn finger	275..295	CDD:275368	7/20 (35%)
		zf-H2C2_2	288..311	CDD:290200	10/23 (43%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		zf-H2C2_2	317..340	CDD:290200	3/22 (14%)
		C2H2 Zn finger	331..351	CDD:275368	3/19 (16%)
		zf-H2C2_2	343..368	CDD:290200	7/24 (29%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		C2H2 Zn finger	387..407	CDD:275368	3/19 (16%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		C2H2 Zn finger	471..491	CDD:275368	9/19 (47%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		zf-H2C2_2	511..536	CDD:290200	11/24 (46%)
		C2H2 Zn finger	527..547	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910