DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp949

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001128003.1	Gene:	Zfp949 / 100233177	RGDID:	2302581	Length:	603	Species:	Rattus norvegicus

Alignment Length:	578	Identity:	146/578 - (25%)
Similarity:	246/578 - (42%)	Gaps:	102/578 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NGSNNSHFL--------DLHHPNCWPSEMAQIRLQ-FANWNLKISPNDGLPQKICSDCFTKFCSI 73
            ||..|:.:|        .:::.||  |.:...:|. :.|..|   |::  |..:|:......|.|
  Rat   114 NGLENTFYLYSMNISNFVVNNGNC--SRVKPEKLHGYLNTCL---PSE--PHGLCTVEQYNDCCI 171

  Fly    74 NAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTAS 138
            ....:.|.|...:.|.:            :.||:|.|...|.::|:..|...:::        .|
  Rat   172 AGKSIRCPEQLGQHSKV------------QTGQQDFEYMGEGKDTKEAKLLKSIA--------PS 216

  Fly   139 DPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQ 203
            ..:.:.:.:.:..|.|:            ..||..:.|...  :.|.|..|.
  Rat   217 KRLHLGLTSCEHGECEQ------------VSVESDVMDNGG--KTTFSRTCN------------- 254

  Fly   204 LLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEK 268
             |.:| .|::...:...|.|.:..|......||||::.:.:|.|.|..|.|.:..:.:|..|...
  Rat   255 -LTKH-QATYLGRKSCKCLENKKTFTSKLDLTVHLRTHNQKKDHICIQCEKPFSTKSSLTVHQRI 317

  Fly   269 YHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSR 333
            :..|..:.|::|.|.|..:.:|..|.:.|..::.|.|..  |.:.|..:.:|..|:.||:|   .
  Rat   318 HTGEKPYGCSVCNKAFRQKSALIVHERTHTGEKPFGCYE--CGKAFQHKWYLKMHQRTHTG---E 377

  Fly   334 KSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERS 398
            |...|..|||.|:....|:.| ...|..:|||:|.||.:.|.:.:...:|    ||.: |..:..
  Rat   378 KPYECKECGKAFLKKSYLKMH-QGTHKSDKPYECENCGKTFHNRSYFNMH----HRTH-TGEKSY 436

  Fly   399 ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSA 463
            .|..|.:.|..:.||..|      ||     |.|:::            |.:|..|.:.|..||.
  Rat   437 ACNECGKAFYQKSDLRRH------QR-----IHNSEK------------LHECKECGKAFQNKSY 478

  Fly   464 LERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH 528
            |:.|..||: .::|:.|..|.|.|:....:..|...|..|||..|:.|||.|..|.||::|...|
  Rat   479 LKTHQKVHT-GEKPYECKECGKAFQNKSYLNKHQIIHTGEKPYECNKCGKMFQWKLVLSKHHRIH 542

  Fly   529 EVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
             ..||.::|..||:.:.::.||.:|:..|:|:..|:|::|::.|.....|..| |:.|
  Rat   543 -TGEKPYECIQCGKMFGYKSSLIVHELIHSGEKPYECNVCRKAFTQKSNLSRH-QRTH 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/77 (22%)
		COG5048	198..>508	CDD:227381	84/309 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp949	NP_001128003.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	269..599	CDD:227381	109/367 (30%)
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		C2H2 Zn finger	298..318	CDD:275368	5/19 (26%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..374	CDD:275368	5/21 (24%)
		zf-H2C2_2	366..389	CDD:290200	10/25 (40%)
		C2H2 Zn finger	382..402	CDD:275368	7/20 (35%)
		C2H2 Zn finger	410..430	CDD:275368	7/23 (30%)
		zf-C2H2	436..458	CDD:278523	8/32 (25%)
		C2H2 Zn finger	438..458	CDD:275368	8/30 (27%)
		zf-H2C2_2	450..473	CDD:290200	10/45 (22%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		zf-H2C2_2	478..501	CDD:290200	8/23 (35%)
		C2H2 Zn finger	494..514	CDD:275368	5/19 (26%)
		zf-H2C2_2	506..529	CDD:290200	9/22 (41%)
		C2H2 Zn finger	522..542	CDD:275368	9/19 (47%)
		zf-H2C2_2	535..559	CDD:290200	8/24 (33%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		zf-C2H2	576..598	CDD:278523	7/22 (32%)
		C2H2 Zn finger	578..598	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000