DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and LOC100125368

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001132959.1	Gene:	LOC100125368 / 100125368	RGDID:	1642422	Length:	501	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	137/475 - (28%)
Similarity:	206/475 - (43%)	Gaps:	68/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 DEEVEEPITDESAPPQLTISYA----C-------KFCLRPQENYQLQQLLLEHINASHDPEQPYN 220
            |..:||.......|.:..|.:.    |       |.|....::: ||  ..|.||..   |:||.
  Rat    49 DSNIEEHCQRSRGPRRYNICHCGYEPCEHWGHGKKQCTFAHKSF-LQ--TYERINTE---EKPYK 107

  Fly   221 CPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFY 285
            |.:|...|.:..|...|.|:...||.:.|..|||.:..|.:|:.|...:..|..|:|:.|.|.|.
  Rat   108 CSQCSKAFANFRSLQKHEKNHTREKPYECSHCGKAFPSRSSLQIHERTHTGEKPFDCSECGKAFA 172

  Fly   286 TRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
            ...:|:.|.:.|..::.:.|..  |.:.|.::.||..||..|:|   .|...|..|||.|.:...
  Rat   173 RHSNLDIHKRTHTGEKPYDCNE--CGKAFSTRSHLQIHEILHTG---EKPYVCNQCGKAFAYRSN 232

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIH 415
            |..| .:.|.|||||:|..|...:||.:..|.|  |:|.   |..:...|..|.:.|:....|..
  Rat   233 LEAH-DKTHTGEKPYECNQCGNAYASRSSLRNH--EKHH---TGEKLYGCNECGRAFARRSSLEI 291

  Fly   416 HMSAEHLQRPGAPIIANN------KRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHS 472
            |   |.......|.:.|.      :|...|..||.::|  .:.|..|.:.|..:::|:.|.. |.
  Rat   292 H---ERTHTGEKPYVCNQCGKAFARRSSLQIHERTHTGEKPYGCNQCGKAFASRTSLQNHEK-HH 352

  Fly   473 EKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH--EVL---- 531
            ..::|:.|..|.|.|:...|::.|.:||..|||..|:.|||||..:..|..|...|  |.|
  Rat   353 TGEKPYGCNQCGKAFELKCDLQIHERTHTGEKPYRCNQCGKAFVSRRYLRNHEKHHTLEKLYDCS 417

  Fly   532 ---------------------EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTH 575
                                 ||.:||..||:|:.:..:|..|:|:|||:..|:|:.|.:.|..:
  Rat   418 QCGKSFAIFRYLQKHKKTHTGEKPYKCTHCGKAFAYRSNLYRHERSHTGEKLYECNECGQAFAYY 482

  Fly   576 IKLKTHMQKAHAASQPHSAD 595
            ..|..| :|.|....||..:
  Rat   483 TSLHNH-RKRHMGENPHECN 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	95/317 (30%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
LOC100125368	NP_001132959.1	KRAB	4..>47	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	104..476	CDD:227381	115/386 (30%)
		C2H2 Zn finger	108..128	CDD:275368	6/19 (32%)
		zf-H2C2_2	120..143	CDD:290200	9/22 (41%)
		C2H2 Zn finger	136..156	CDD:275368	7/19 (37%)
		zf-H2C2_2	148..173	CDD:290200	8/24 (33%)
		C2H2 Zn finger	164..184	CDD:275368	6/19 (32%)
		zf-H2C2_2	176..201	CDD:290200	6/26 (23%)
		C2H2 Zn finger	192..212	CDD:275368	7/21 (33%)
		zf-H2C2_2	204..229	CDD:290200	12/27 (44%)
		C2H2 Zn finger	220..240	CDD:275368	7/20 (35%)
		C2H2 Zn finger	248..268	CDD:275368	7/21 (33%)
		C2H2 Zn finger	276..296	CDD:275368	6/22 (27%)
		zf-H2C2_2	288..313	CDD:290200	5/27 (19%)
		C2H2 Zn finger	304..324	CDD:275368	5/19 (26%)
		C2H2 Zn finger	332..352	CDD:275368	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..397	CDD:290200	13/24 (54%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	416..436	CDD:275368	0/19 (0%)
		zf-H2C2_2	428..453	CDD:290200	7/24 (29%)
		C2H2 Zn finger	444..464	CDD:275368	7/19 (37%)
		zf-H2C2_2	456..481	CDD:290200	10/24 (42%)
		C2H2 Zn finger	472..492	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100