DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp867

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001103147.2	Gene:	Zfp867 / 100125361	RGDID:	1642427	Length:	459	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	117/473 - (24%)
Similarity:	193/473 - (40%)	Gaps:	71/473 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 EIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPIT----------DESAPPQLTISYACKFCLRPQ 196
            |:|.:...|::..|::..|::.:..:..:...|.          :.|..|.....|...|
  Rat    35 EVFRNLTSIEKGWEDQNIEDEDKSPETNLRHIIANSGCNLYESEEHSEKPYKFTQYRNSF----- 94

  Fly   197 ENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHN 261
                :..:.::.........:||.|..|...|...:...:||::...||.:.|..|||.:....:
  Rat    95 ----ISLMSIQRHMIMDTGSKPYKCMLCGKAFHFPSEFRIHLRTHTGEKPYECKQCGKAFSHSSS 155

  Fly   262 LRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEAT 326
            .|.|...:..|..:.|..|.|.|....|:..|.:.|..::.::|:.  |.:.|....:|..||.:
  Rat   156 FRKHERTHTGERPYVCKQCGKAFNCSGSIRKHERTHTGEKPYECKQ--CGKAFNCPSYLQIHERS 218

  Fly   327 HSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHREN 391
            |:|   .|...|..|||||....:||.| .|.|.|||||:|..|.:.|:..:..|     :|...
  Rat   219 HTG---EKPYECKQCGKTFSCSSSLRKH-ERTHTGEKPYECKQCGKAFSCSSSFR-----KHERT 274

  Fly   392 LTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQ 456
            .|.....||..|.:.|.|...:..||    ::..|                   :|.|:|..|.:
  Rat   275 HTGERPYECKQCGKAFFSLTSVRTHM----IKHTG-------------------NGPFKCSVCEE 316

  Fly   457 RFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVL 521
            .|...|...||...|: .::.:.|..|:|.|..:..:..|.::|..|||..|...||||     :
  Rat   317 VFPFSSVFRRHQTSHA-GEKLYECKQCNKWFSSSTSLHNHERSHNGEKPYTCKPRGKAF-----I 375

  Fly   522 TQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            .:|..:| ...|::.|..||..:....||::|.|..||:..:||    |:....:...|.|:| |
  Rat   376 RKHERAH-AGGKSYPCKQCGEWFSASSSLQMHGRIQTGEKPHKC----EQGARALSCSTCMRK-H 434

  Fly   587 AASQ------PHSADQPL 598
            ..:|      .:..::||
  Rat   435 EQTQSGGKAYDYGVEKPL 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	80/309 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp867	NP_001103147.2	KRAB	4..>44	CDD:214630	2/8 (25%)
		KRAB	4..43	CDD:279668	2/7 (29%)
		C2H2 Zn finger	115..135	CDD:275368	5/19 (26%)
		zf-H2C2_2	127..152	CDD:290200	8/24 (33%)
		COG5048	<139..299	CDD:227381	51/170 (30%)
		C2H2 Zn finger	143..163	CDD:275368	6/19 (32%)
		zf-H2C2_2	155..180	CDD:290200	7/24 (29%)
		C2H2 Zn finger	171..191	CDD:275368	6/19 (32%)
		zf-H2C2_2	183..208	CDD:290200	6/26 (23%)
		C2H2 Zn finger	199..219	CDD:275368	6/21 (29%)
		zf-H2C2_2	211..236	CDD:290200	12/27 (44%)
		COG5048	<223..382	CDD:227381	55/193 (28%)
		C2H2 Zn finger	227..247	CDD:275368	10/20 (50%)
		zf-H2C2_2	239..264	CDD:290200	13/25 (52%)
		C2H2 Zn finger	255..275	CDD:275368	5/24 (21%)
		zf-H2C2_2	267..290	CDD:290200	6/27 (22%)
		C2H2 Zn finger	283..303	CDD:275368	6/23 (26%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..434	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100