DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Rex2

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001171238.1	Gene:	Rex2 / 100043034	MGIID:	1328322	Length:	685	Species:	Mus musculus

Alignment Length:	585	Identity:	149/585 - (25%)
Similarity:	234/585 - (40%)	Gaps:	111/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 HQETETT------KPTTTVSAETQPNNTASDP-IEIFVDAVD------IDEAEEEEEEEEQQQQY 166
            |:.:|:|      :..|..|:..:.:.|.:.. :..:.|.|:      |....:....|:::...
Mouse   111 HESSESTPYNTNHRDATLQSSNLKRHKTGTTKGVCTYKDCVNCLKGSSIISLNQGTHIEKKEHNR 175

  Fly   167 DEEVEEPITDESAPPQLTISYAC-KF--CLRPQENYQLQQLL------------------LEHI- 209
            ::.::|.:.......::. :|.| :|  |....:|.|.||.:                  ..|:
Mouse   176 NKNLDEVLVSRQNNSEMN-TYTCGEFDKCFTQSDNLQSQQRIYPGKKSYKYSESDKCFTQTSHLS 239

  Fly   210 --NASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSE 272
              :..|..|:||.|.||:..|.|..:...|.:....||.:.|..|.|.:.|:..||.|...:..|
Mouse   240 IHHTIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCSECDKCFTDKCTLRKHQRIHTGE 304

  Fly   273 TDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEH 337
            ..::|..|:|.|..:.||..|.:.|..::.:||  |.|::.|....||..|...|||   .|...
Mouse   305 KPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKC--SECDKCFTQPSHLSIHRRIHSG---EKPYK 364

  Fly   338 CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANC----TEVFASYAEKRIHMLER----------- 387
            |..|.|.|....|||.| .|.|.|||||||:.|    ||.|.....:|||..|:
Mouse   365 CSECDKCFTDKCTLRKH-QRIHTGEKPYKCSECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCF 428

  Fly   388 --------HRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------------GAPIIAN 432
                    |:...|..:..:|..|.:.|:....|..|......::|            .:|:..:
Mouse   429 TDKGSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIH 493

  Fly   433 NK-----------------------RVLQQKR--ERQYSGLFQCGSCSQRFNMKSALERHAAVHS 472
            .:                       ||.|:..  |:.|    :|..|.:.|...|.|..|..:||
Mouse   494 RRIHSGEKPYKCSECDKCFTDKGSLRVHQRIHIGEKPY----KCSECDKCFTQPSHLSIHCRIHS 554

  Fly   473 EKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKC 537
             .::|:.|..|.|.|.....::.|.:.|..|||..|..|.|.|..|..|.:|:..| ..||.:||
Mouse   555 -GEKPYKCSECDKCFTHKGSLRVHHRIHAGEKPYKCSECDKCFTEKNGLRRHQRIH-TGEKPYKC 617

  Fly   538 NVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQPLDDLI 602
            :.|.:.:..:..|.:|||.|||:..|||..|.:.|.....|..| ||.|:.....:|....:.|:
Mouse   618 SECDKCFTRKSHLSIHQRIHTGEKLYKCSECDKCFTQQCHLSIH-QKIHSGENLTNAMNATNALV 681

Fly 603 602
Mouse 682 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	102/390 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	7/20 (35%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Rex2	NP_001171238.1	KRAB	27..67	CDD:366587
		C2H2 Zn finger	197..217	CDD:275368	7/19 (37%)
		C2H2 Zn finger	229..245	CDD:275368	1/15 (7%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		COG5048	277..666	CDD:227381	115/401 (29%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	7/21 (33%)
		C2H2 Zn finger	365..385	CDD:275368	9/20 (45%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	1/19 (5%)
		C2H2 Zn finger	449..469	CDD:275368	5/19 (26%)
		C2H2 Zn finger	477..497	CDD:275368	1/19 (5%)
		C2H2 Zn finger	505..525	CDD:275368	3/19 (16%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	617..637	CDD:275368	6/19 (32%)
		C2H2 Zn finger	645..665	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100