DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp984

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001120661.1	Gene:	Zfp984 / 100041677	MGIID:	3651978	Length:	547	Species:	Mus musculus

Alignment Length:	571	Identity:	141/571 - (24%)
Similarity:	223/571 - (39%)	Gaps:	124/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKIC--SDCFTKFCSINAFRLACQEAQLKLSHI 90
            |..|.|.|.:.....||::| ..::.|.:  .:::|  :|      |:|:..|....:..:..|:
Mouse    94 LESPQCTPYKTNHSSLQYSN-QKRLKPRN--TKEVCKYND------SVNSVSLFSTISLNQGIHL 149

  Fly    91 YDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEE 155
            ..|....:.|.:::.      ..:|:            ...:.|||..:|
Mouse   150 QKKKHNRNAEFEKVF------VSKHK------------VMVKRNNTGVNP--------------- 181

  Fly   156 EEEEEEQQQQYDEEVEEPITDESAPPQLTISYAC----KFCLRPQENYQLQQLLLEHINASHDPE 216
                                           |.|    |: |..:|..|.||.:       :..:
Mouse   182 -------------------------------YKCSEFDKY-LTQREKLQSQQRI-------YHGK 207

  Fly   217 QPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCE 281
            :||...:.:..|......::|......||.:.|..|.|.:..:.:|..|...:..|..::|:.|:
Mouse   208 KPYRSSKSDKCFTHQIHLSIHQGIHAEEKIYKCSECDKCFTHKSHLNIHQRIHTGENPYKCSECD 272

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|..:.|.:.|.:.|..::.:||  |.|::.|..:.||..|:..|:|   .|...|..|.|.|.
Mouse   273 KCFKHKFSFSMHQRIHTGEKPYKC--SECDKCFTQKSHLSVHQRIHTG---EKPYKCSECDKCFT 332

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            |...|..| .|.|.|||||||:.|.:.|......|||......||  ..:.|||..|   |:.:.
Mouse   333 HKSHLNSH-QRIHTGEKPYKCSECDKCFTKNGSLRIHQRIHTGEN--PYKCSECDKC---FTHKS 391

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDR 476
            :|..|......::|                       ::|..|.:.|..||.|..|..:|: .::
Mouse   392 NLNIHQRIHTGEKP-----------------------YKCSECDKCFTHKSHLNSHQRIHT-GEK 432

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            |:.|..|.|.|.|...:..|.:.|..|.|..|..|.|.|..|..|..|:..| ..||.:||:.|.
Mouse   433 PYKCSECDKCFTRKFHLSIHQRIHTGENPYKCSECDKCFTQKSNLNIHQRIH-TGEKPYKCSECD 496

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            :.:..:.|||:|||.|||:..|||..|.:.|.....|..| ||.|...:|:
Mouse   497 KCFTEKGSLRIHQRIHTGENPYKCSECDKCFTRKFHLSIH-QKIHTGEKPY 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/60 (22%)
		COG5048	198..>508	CDD:227381	82/309 (27%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp984	NP_001120661.1	KRAB	12..52	CDD:396083
		C2H2 Zn finger	184..204	CDD:275368	7/27 (26%)
		C2H2 Zn finger	216..232	CDD:275368	2/15 (13%)
		COG5048	<220..465	CDD:227381	76/279 (27%)
		C2H2 Zn finger	240..260	CDD:275368	5/19 (26%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	296..316	CDD:275368	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	8/20 (40%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	380..400	CDD:275368	7/22 (32%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..500	CDD:404364	8/24 (33%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
		zf-H2C2_2	504..529	CDD:404364	14/24 (58%)
		C2H2 Zn finger	520..540	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100