DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zkscan16

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001092793.1	Gene:	Zkscan16 / 100041581	MGIID:	3510405	Length:	728	Species:	Mus musculus

Alignment Length:	488	Identity:	115/488 - (23%)
Similarity:	188/488 - (38%)	Gaps:	76/488 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPT-----TTVSAETQPNNTASDPI 141
            :.:.:..|...|.|.......|..:.:.|.....:..:.|..|     .::|..:|.:.....|.
Mouse   279 KTEFQRRHGKPKKDHGKRSSHENRESETEGTSSGKRVKQTSDTLKHRKASLSKMSQRSKEGKKPF 343

  Fly   142 EIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQ---LTISYACKFCLRPQENYQLQQ 203
            ......|:..|...|:..:..:.:.|........:....|:   |:.:..|..|     .....|
Mouse   344 SFHSALVNRRELRREKSRKCGEPEKDPRRHLSPAERKRHPKIGSLSKTETCSKC-----GVAFTQ 403

  Fly   204 LLLEHINASHDPEQPYNCPECEAR-FQDAASRTVHLKSSHVEKQHACGVCGKKY--GDRHNL--- 262
            :|...|.:|       .|.:|... |||.|..  ..|....|:...||.|||.:  |.:.::
Mouse   404 ILENCIESS-------QCEKCRKNLFQDEAPN--QDKEPDPEEASKCGKCGKAFEPGTKRSVCLE 459

  Fly   263 -----------RHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS 316
                       :.|.:....|..::|..|.|||.....|.:|.:.|..::.:.|:|  |.|.|..
Mouse   460 CRKAPKASASPKPHNKADRKEKRYKCDECGKRFAELYFLTHHQRTHTGEKPYVCKH--CGRPFSD 522

  Fly   317 QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381
            ......|:..|:|   .|...|..|||:|.|..:|..| .|.|.|||||||..|.:.|     ::
Mouse   523 YSSFYQHQRIHTG---EKPYTCKECGKSFTHSSSLSKH-QRIHTGEKPYKCNECGKAF-----RQ 578

  Fly   382 IHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYS 446
            ...|.||::..|..:...|..|...|.....:::|......::|
Mouse   579 NSCLTRHQKIHTGEKPFLCKDCGLSFRLFSSIMYHQRLHAGEKP--------------------- 622

  Fly   447 GLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
              ::|..|.:.|...|.|.||...|:.. :|:.|..|.|.|:::..:..||:||..|||..||.|
Mouse   623 --YKCTHCEKGFPSHSRLSRHLRCHTGA-KPYKCKECGKTFRQSSSLNLHIRTHTGEKPYKCDYC 684

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY 544
            |.||....:|.:|..:|..::  ::|..||:.:
Mouse   685 GAAFTRSTILIEHVKTHTNVQ--YECKKCGKTF 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	0/4 (0%)
		COG5048	198..>508	CDD:227381	85/326 (26%)
		C2H2 Zn finger	221..241	CDD:275368	7/20 (35%)
		C2H2 Zn finger	249..269	CDD:275368	7/35 (20%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	3/8 (38%)
		C2H2 Zn finger	565..582	CDD:275368
Zkscan16	NP_001092793.1	SCAN	45..132	CDD:366881
		KRAB	170..223	CDD:214630
		PRK07219	<383..489	CDD:235971	25/119 (21%)
		C2H2 Zn finger	457..477	CDD:275368	1/19 (5%)
		COG5048	<462..608	CDD:227381	45/156 (29%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	6/21 (29%)
		COG5048	<537..725	CDD:227381	61/211 (29%)
		C2H2 Zn finger	541..561	CDD:275368	9/20 (45%)
		C2H2 Zn finger	569..589	CDD:275368	6/24 (25%)
		C2H2 Zn finger	597..617	CDD:275368	4/19 (21%)
		C2H2 Zn finger	625..645	CDD:275368	7/19 (37%)
		C2H2 Zn finger	653..673	CDD:275368	6/19 (32%)
		C2H2 Zn finger	681..701	CDD:275368	8/19 (42%)
		C2H2 Zn finger	708..725	CDD:275368	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100