DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp981

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001230067.1	Gene:	Zfp981 / 100041433	MGIID:	3700965	Length:	445	Species:	Mus musculus

Alignment Length:	447	Identity:	109/447 - (24%)
Similarity:	172/447 - (38%)	Gaps:	127/447 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LQQLLLEH-------------INASHDPEQ--PYNCPECEARFQDA------------------- 231
            :|.::.||             .|..|:..:  |||..:.:|.||.:
Mouse    69 IQHIVNEHGHIRKKSSKCNELSNVIHESSESTPYNTNQRDATFQFSNLKRHKTGTTKEVCTYKDC 133

  Fly   232 -----ASRTVHL-KSSHVEKQHACGVCGKKYGDRHNL------RHH--VEKYHSETD-FECALCE 281
                 .|..:.| :.:|:||        |::....||      :|.  |.:.:||.: :.|...:
Mouse   134 VNCLKGSSIISLNQGTHIEK--------KEHNRNKNLDEVLVSKHKPIVRQNNSEMNTYTCGEFD 190

  Fly   282 KRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFI 346
            |.|....||....:  .|.:: ..::|..::.|....||..|...|||   .|...|..|.|.|.
Mouse   191 KCFTQSDSLQSQQR--KPGKK-SYKYSESDKCFTQPSHLSIHHTIHSG---EKPYKCSECDKCFT 249

  Fly   347 HLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ...|||.| .|.|.|||||||:.|.:.|......|:|
Mouse   250 DKCTLRKH-QRIHTGEKPYKCSECDKCFTDKGYLRVH---------------------------- 285

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEK 474
                                          :|.::|  .::|..|.:.|..|..|..|..:|: .
Mouse   286 ------------------------------QRIHTGEKPYKCSECDKCFTDKGYLRVHQRIHT-G 319

  Fly   475 DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNV 539
            ::|:.|..|.|.|.:...:.:|.:.|..|||..|..|.|.|..|::|.:|:..| ..:|.:||:.
Mouse   320 EKPYKCSECDKCFTQPSHLSFHRRIHSGEKPYKCSECDKCFTDKFILGKHQRIH-TGKKPYKCSE 383

  Fly   540 CGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            |.:.:..:..||:|||.|||:..|||..|.:.|.....|..| ||.|:..:|:..::
Mouse   384 CDKCFTDKGYLRVHQRIHTGEKPYKCSECDKCFTQQCHLSIH-QKIHSGEKPYKCNE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	78/357 (22%)
		C2H2 Zn finger	221..241	CDD:275368	5/44 (11%)
		C2H2 Zn finger	249..269	CDD:275368	5/27 (19%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp981	NP_001230067.1	KRAB	13..>55	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	45..410	CDD:227381	100/415 (24%)
		C2H2 Zn finger	186..205	CDD:275368	5/20 (25%)
		C2H2 Zn finger	217..233	CDD:275368	4/15 (27%)
		C2H2 Zn finger	241..261	CDD:275368	9/20 (45%)
		zf-H2C2_2	254..277	CDD:290200	13/23 (57%)
		C2H2 Zn finger	269..289	CDD:275368	6/77 (8%)
		zf-H2C2_2	281..305	CDD:290200	6/81 (7%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..334	CDD:290200	8/25 (32%)
		C2H2 Zn finger	325..345	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	8/23 (35%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	393..418	CDD:290200	13/24 (54%)
		C2H2 Zn finger	409..429	CDD:275368	7/20 (35%)
		zf-H2C2_2	421..445	CDD:290200	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100