DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and si:ch211-202h22.10

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_017212100.2	Gene:	si:ch211-202h22.10 / 100002322	ZFINID:	ZDB-GENE-110914-121	Length:	519	Species:	Danio rerio

Alignment Length:	415	Identity:	130/415 - (31%)
Similarity:	195/415 - (46%)	Gaps:	23/415 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGV 251
            :.|..|   .::...:|.|..|:.. |..|:|:.||||...|........|:::....|..:|..
Zfish    66 FTCPQC---DKSVTSKQSLKSHMRI-HTGEKPFTCPECGMIFSQLGYLKRHVRTHTGLKPFSCTQ 126

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS 316
            |||:|..:.:|..|:..:..|..|.|..|.|.|..::.|..||..|..::.|.|  |.||..|..
Zfish   127 CGKRYKVKQSLESHMRVHTGEKPFACPQCGKGFTAKQCLKSHMSVHIEEKPFNC--SLCEMSFTH 189

  Fly   317 QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381
            |:.|..|...|.|   .|...|..|||:|...::|..|| |.|.||||:.||.|.:.||....
Zfish   190 QQSLKRHMLIHVG---EKPYVCRQCGKSFSVKQSLESHI-RIHTGEKPFACAECGKGFAVKQN-- 248

  Fly   382 IHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRE---R 443
               ||.|....|.::...|..|.:.|:.:..|..||:....:||....:.:....::.|.|   |
Zfish   249 ---LESHMRVHTGVKPFSCPQCGKRFTVKQSLESHMTIHTGERPFTCSMCDKTFTVKHKLEYHMR 310

  Fly   444 QYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPN 506
            .::|  .:.|..|...:.:::.||||..:|: .::|.:|..|:|||...|.:|.|::.|.:.||.
Zfish   311 NHTGEKPYICPQCGNSYALRNHLERHVRIHT-GEKPFSCSKCAKRFTMKQSLKSHMRVHNRTKPY 374

  Fly   507 VCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQER 571
            :|..|||.|.:|..|..| :|....||.|.|..||::|...:||..|.|.|||...:.|..|...
Zfish   375 ICSQCGKRFTVKQSLESH-MSLHTGEKPFTCTECGKSYTLRQSLETHMRVHTGDKCFSCSDCGRS 438

  Fly   572 FVTHIKLKTHMQKAHAASQPHSADQ 596
            |.....|..|| :.|...:|::..|
Zfish   439 FTVKQNLHVHM-RVHTGERPYTCAQ 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	96/314 (31%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
si:ch211-202h22.10	XP_017212100.2	C2H2 Zn finger	12..32	CDD:275368
		COG5048	36..439	CDD:227381	123/389 (32%)
		C2H2 Zn finger	40..60	CDD:275368
		C2H2 Zn finger	68..88	CDD:275368	5/23 (22%)
		C2H2 Zn finger	96..116	CDD:275368	6/19 (32%)
		C2H2 Zn finger	124..144	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		C2H2 Zn finger	180..200	CDD:275368	8/21 (38%)
		C2H2 Zn finger	208..228	CDD:275368	9/20 (45%)
		C2H2 Zn finger	236..256	CDD:275368	8/24 (33%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		C2H2 Zn finger	292..312	CDD:275368	3/19 (16%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	348..368	CDD:275368	8/19 (42%)
		C2H2 Zn finger	376..396	CDD:275368	9/20 (45%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	6/20 (30%)
		zf-H2C2_2	448..469	CDD:316026	5/16 (31%)
		C2H2 Zn finger	460..480	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910