DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Son and SQS1

DIOPT Version :9

Sequence 1:	NP_001262426.1	Gene:	Son / 41159	FlyBaseID:	FBgn0037716	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_014175.1	Gene:	SQS1 / 855497	SGDID:	S000005168	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	746	Identity:	130/746 - (17%)
Similarity:	245/746 - (32%)	Gaps:	232/746 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 FKKKKKVKKEKKD--KKAKKKKTTKSDGECSDSEAEGKHKHKRKKHKHKDIRVKDKE-KDRDRDK 188
            |.|.|:|.....:  :|.:.|..||:..|..:.||:...:..:.....:.|..:|.| :|.|...
Yeast   123 FVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINNEDSENEDDDSQN 187

  Fly   189 SKEKDRDRVTDKSKEKDRDR---DRDRDKSKDKFTAAQA-------PSE---------------- 227
            |...|....:::||.:|.|.   |.:..:|.|.....:.       |.|
Yeast   188 SPSTDHSLSSNESKVEDGDLFFVDEEAQQSPDLTKIKRVCIEEIARPREVAIEFDPILTIGKVEL 252

  Fly   228 KEKEKSESRKRSAVEPSS-------------------HSEKRERHEREKHRDWEREREREKEHER 273
            ...|.:||::.|...|:.                   |:...:..|    .|:|.|.|...|...
Yeast   253 SVSEGNESKEISVDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDE----LDYEIETENNSEPLY 313

  Fly   274 ERVRS---NNSF-YNGQREADRLKGSESASTKSRQEQDLSDISLSDEESYLREKASNGRRRAHNS 334
            |...|   :..| |.|||...|...:...|...:..:|:..:|::..:::.....:.....:...
Yeast   314 ESSASSEVDQGFNYVGQRHNSRADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDNLPSPASEEL 378

  Fly   335 FYDEKEELSVSPKRNVRESNTRRNRKSRSRSRDLGIDKKRLLEIAR-----------RNAINMF- 387
            .:..|||..|....::..||.|..          |:|....|...|           ::.:..|
Yeast   379 EFGFKEEDFVINTNDIVVSNIRMG----------GVDNSYYLRCYRLLGDYDFHWIDQDLLTDFV 433

  Fly   388 ------KQGTMPGVANMTAEVKDKVLVKMR--------------------YGGRTIQDLTDFCKK 426
                  .:..:|...|.   :|:.::.|:.                    |.|.:.:|..|....
Yeast   434 VDELGLPEDRLPAYLNF---IKNSLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASS 495

  Fly   427 ISNGD---GLSDL---SSEEESDVDKNGNAKVFHHPFQLKEREPIVMHIRNSTALVPAPPRLDEQ 485
            :.:.|   ||.||   :.:.:::..|....|......:.|:::.::     ..||.     ||.:
Yeast   496 VVHSDIEEGLDDLIAYTLKHDTERFKTFETKSLETKGKGKKKKLLI-----DDALA-----LDTE 550

  Fly   486 TKAITMQFPVS-----SGQTHRNNEVWVPVDPKDSLVPLPSLPPAKQATNMFKETPKNVFAKSIP 545
            |.. |:|...|     ..:..:..|.::..:.::|             .:|.|:.|..:..::|
Yeast   551 TLE-TLQSKFSKRIETKAKKRKAKEDFIDQENRNS-------------NDMLKKYPYGLHIQNI- 600

  Fly   546 LQEQQEPAFKPLGGAVVVPPL-----------------------AATQLPTVPQSVPPTVPKEFA 587
             :::.|.........:..|||                       .|.....|.:.:..|   :::
Yeast   601 -KDEFESFLSRNNDRLTFPPLDPHGNKTVMKIAKHYNMKSSKIGKANHTSVVVEKIKKT---KWS 661

  Fly   588 PPAVPFVPEVPIPSTSPVTPMQSASIFPDVTPPSMDVSSIITQRLSAIRRLQENPADSEALKMMY 652
            .|....:.::          |:...:|..:.                |||.:|..|
Yeast   662 SPNYSLIDQL----------MRQRPVFMRID----------------IRRPREEQA--------- 691

  Fly   653 TAQRNMSSWANSKHLPGQFTGSTGAQV-MKAHELNSGPQLWVRKDQMTSTKPVTGGMGMALLQKM 716
                   ::..:|.:.|:|....|..| ..|.|:.:                  ..:|..:|:|:
Yeast   692 -------AFERTKTIRGKFHVKEGEIVGQNAPEIGN------------------ENIGRRMLEKL 731

  Fly   717 GWKPGEGLG-RCKTGSLQPLLLDVKLDKRGL 746
            |||.||||| :...|..:|:...:|.::.||
Yeast   732 GWKSGEGLGIQGNKGISEPIFAKIKKNRSGL 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_001262426.1	PHA03247	<455..627	CDD:223021	25/199 (13%)
		G-patch	705..747	CDD:396249	16/43 (37%)
		DSRM_SON-like	798..872	CDD:380699
SQS1	NP_014175.1	R3H_G-patch	597..654	CDD:100075	7/58 (12%)
SQS1	NP_014175.1	G-patch	721..764	CDD:396249	16/42 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940