DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Son and Gpatch2

DIOPT Version :9

Sequence 1:	NP_001262426.1	Gene:	Son / 41159	FlyBaseID:	FBgn0037716	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_080643.4	Gene:	Gpatch2 / 67769	MGIID:	1915019	Length:	527	Species:	Mus musculus

Alignment Length:	615	Identity:	122/615 - (19%)
Similarity:	202/615 - (32%)	Gaps:	181/615 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 SAVEPSSHSEK---RERHEREKHRDWEREREREKEHERERVRSNNSFYNGQREADRLKGSESAST 300
            ||:|.||...:   .|..|..::.....:|:..|...|:| ||.|..:..:......:||:|
Mouse    33 SALEESSEQARGGFAETGEHSRNLSCPLKRQARKRRGRKR-RSYNVHHPWETGHCLSEGSDS--- 93

  Fly   301 KSRQEQDLSDISLSDEESYLREKASNGRRRAHNSFYDEKEELSVSPKR-NVRESNTRRNRKSRSR 364
                       ||.:.....|||.||.::...    |..:::.|:.:| :...|::.|.::....
Mouse    94 -----------SLEEPSKDYREKHSNNKKDRS----DSDDQMLVAKRRPSSNLSSSVRGKRLLWH 143

  Fly   365 SRDLGIDKKRLLEIARRNAINMFKQGTMPGVANMTAEVKDKVLVKMRYGGRTIQDLTDFCKKISN 429
            ..|..:|......:.||..           |..|..::...|..|     ||:..|.:.|:.
Mouse   144 ESDFAVDSLGNRTLRRRRK-----------VKRMAVDLPQDVSSK-----RTMTQLPEGCRD--- 189

  Fly   430 GDGLSDLSSEEESDVDKNGNAKVFHHPFQLKEREPIVMHIRNSTALVPAPPRLDEQTKAITMQFP 494
                .|:.::..|...:....||       |:|:  :..||..       |:..|:...:..:
Mouse   190 ----QDMDNDRASQYPEFTRKKV-------KKRK--LKGIRPG-------PKTQEEGGVLESE-- 232

  Fly   495 VSSGQTHRNNEVWVPVDPKDSLVPLPSLPPAKQATNMFKETPKNVFAKSIPLQ--EQQEPAF--K 555
             ...|.:::...:......|.|       .::..|:....|...:|......|  ::|...|  |
Mouse   233 -ERSQPNKDRMEYEEQKASDEL-------RSESDTSSLSSTDAGLFTNDEGRQGDDEQSDWFYEK 289

  Fly   556 PLGGAV----VVPPLAATQLPTVPQSVPPTVPKEFAPPAVP---------FVPEVPIPSTSPVTP 607
            ..|||.    |||.....:...:..::|..|.:.....:.|         |...:.....:|...
Mouse   290 ESGGACGIAGVVPWWEKDEPAELDTNLPDPVFESILSGSFPLMSHPGRGGFQARLSRLHGTPSKN 354

  Fly   608 MQSASIFPDVTPPSMDVSSIITQRLSAIRRLQENPADSEALKMMY---TAQRN---MSSWANSKH 666
            ::.:|    ..||||         |||       |......:|::   .|.|:   .|..|.::|
Mouse   355 IKKSS----GAPPSM---------LSA-------PGPGSNKRMVHFSPDAHRHDHWFSPGARTEH 399

  Fly   667 LPGQFTGSTGAQVMKAHELNSGPQLWVRKDQM-------------TSTKPVTG------------ 706
            ...|......|:  :.|:.:...:...|:..|             ....|:.|
Mouse   400 GQHQLLRDNRAE--RGHKKSCSLKTASRQTSMHLGSLCTGDIKRRRKAAPLPGPTAAGIVGENAQ 462

  Fly   707 -----GMGMALLQKMGWKPGEGLGRCKTGSLQPLLLDVKLDKRGLVSRDDLRPPQMRAPAAQRRN 766
                 .:|..:||.|||.||.||||               |.||:.     .|.|    |.||
Mouse   463 PILESNIGNRMLQSMGWTPGSGLGR---------------DGRGIA-----EPVQ----AVQR-- 501

  Fly   767 KNMAGPIGAG---PCPAVQGAGPGPLASTP 793
                 |.|.|   |.|......|.|.:..|
Mouse   502 -----PKGLGLGFPLPKSSPTSPAPTSGNP 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_001262426.1	PHA03247	<455..627	CDD:223021	32/188 (17%)
		G-patch	705..747	CDD:396249	16/58 (28%)
		DSRM_SON-like	798..872	CDD:380699
Gpatch2	NP_080643.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..135		26/118 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..281		22/143 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..375		10/44 (23%)
		G-patch	467..510	CDD:279867	23/73 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..527		22/78 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030