DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Son and Aggf1

DIOPT Version :9

Sequence 1:	NP_001262426.1	Gene:	Son / 41159	FlyBaseID:	FBgn0037716	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_079906.2	Gene:	Aggf1 / 66549	MGIID:	1913799	Length:	711	Species:	Mus musculus

Alignment Length:	746	Identity:	134/746 - (17%)
Similarity:	247/746 - (33%)	Gaps:	218/746 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PPEELLDDNLFKKKKKVKKEKKDKKAKKKKTTKSDGECSDSEAEGKHKHKRKKHKHKDIRVKDKE 181
            ||....:..|.:.::||:|.:::.::.:::.         .|.|...:|..:.:
Mouse    14 PPPASPEPELAQLRRKVEKLERELRSCRRQV---------REVEKLLQHTERLY----------- 58

  Fly   182 KDRDRDKSKEKDRDRVTDKSKEKDRDRDRDRDKSK-DKFTAAQAP-----------------SEK 228
              |:.:...::.|.:|.:.||.....::.|..||. :..|.:|||                 ..|
Mouse    59 --RNAESDNQELRTQVEELSKILHCGKNEDNPKSDVEVQTESQAPWAISDYYYQTCYNDDSLPSK 121

  Fly   229 EKE----KSESRKRSAVEP--SSHSEK-----RERHEREKHRDWEREREREKEHERERVRSNN-S 281
            |.|    :|:..:.||::|  .||.:.     .:..|...||            :.:.|.|:: .
Mouse   122 ETELCVQQSQCAQASALDPQDESHIDSGSYAGADATEGVSHR------------QEDAVTSDSQE 174

  Fly   282 FYNGQREADRLKGSESA-STKSRQEQDLSDISLSDEESYLREKASNGRRRAHNS--FYDEKEELS 343
            ..:...|...|:||..| |.::..|..:|....:.:|       |.|....|::  :||.:.:|.
Mouse   175 SVSALAEGPALEGSSLAESLRAAAEAAVSQTGFTYDE-------STGLYFDHSTGFYYDSENQLY 232

  Fly   344 VSPKRNV----------------------RESNTRRNRKSRSRSR-------------DLGIDKK 373
            ..|...:                      :.|:|:.||:.|.:.|             ||..:.:
Mouse   233 YDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSSTKPNRERRLKKRRKEPGFYTANEEKDLSSEDQ 297

  Fly   374 RLLEIARRNAINMFKQGTMPGVANMTAEVKDKVL-VKMRYGGRTIQDLTDFCKKISNGDGLSDLS 437
            ::..:...|.......|.:...|......|...| :.:...|.|::...|.....|..:.:.:..
Mouse   298 KVCSVEYINCSEDEHSGNVKKKARTDTSHKSSPLQLTVAVSGDTVESPGDDNSASSKDERIGESE 362

  Fly   438 SE-EESDVDKNGNAKVFHHPFQLKEREPIVMHIRNSTALVPAPPRLDEQTKAITMQFPVSSGQTH 501
            || ||.::..:.:.|.:.......:||                                :|.::.
Mouse   363 SEPEEGEITDSQSEKSYDGDSSSGDRE--------------------------------TSEESD 395

  Fly   502 RNNE--VW----------VPVDPKDSLVPLPSLPPAKQATNMFKETPKNVFAKSIPLQEQQEPAF 554
            ..:|  :|          .||....||..:.::.||  .....|:....|....:.:.:.....:
Mouse   396 DEDEERIWPPCIRVIVIRSPVLQMGSLFIITAVSPA--TIGREKDMEHTVRIPEVAVSKFHAEVY 458

  Fly   555 --KPLGGAVVVPPLAATQLPTVPQSVPPTVPKEFAPPAV-PFVPEVPIPSTSPVTPMQSASIFP- 615
              ..|...|:|.  ..:|..|:........||....|.| ....||.|..|     :.|..|.|
Mouse   459 FDHDLQSYVLVD--QGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGET-----VLSFHIHPG 516

  Fly   616 -----------------------DVTPPSMDVSSIITQRLSAIRRLQ-----ENPADSEALKMMY 652
                                   .:..|::.......:|..|:::::     :| .|.||.|.:
Mouse   517 SETCDGCEPGQVRAHLRLDRKDEPLVGPALSKEEKELERRKALKKIRVKYGLQN-TDYEAEKAL- 579

  Fly   653 TAQRNMSSWANSKHLPGQFTGSTGAQVMKAHELNSGPQLWVRKDQMTS--TKPVTGGMGMALLQK 715
                     .|.|:..         :..|..|.......:.|.|...|  ::......|..:|:|
Mouse   580 ---------KNPKYKD---------RAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEK 626

  Fly   716 MGWKPGEGLGRCKTGSLQPLLLDVKLDKRGL 746
            ||||.|||||:...|...|:.|.::....||
Mouse   627 MGWKRGEGLGKDGGGMKTPIQLQLRRTHAGL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_001262426.1	PHA03247	<455..627	CDD:223021	30/210 (14%)
		G-patch	705..747	CDD:396249	17/42 (40%)
		DSRM_SON-like	798..872	CDD:380699
Aggf1	NP_079906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..184		10/58 (17%)
		OCRE_VG5Q	200..253	CDD:293883	9/59 (15%)
		OCRE repeat 1	205..212	CDD:293883	1/13 (8%)
		OCRE repeat 2	213..220	CDD:293883	1/6 (17%)
		OCRE repeat 3	221..228	CDD:293883	2/6 (33%)
		OCRE repeat 4	229..235	CDD:293883	1/5 (20%)
		OCRE repeat 5	238..245	CDD:293883	0/6 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..297		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..400		16/120 (13%)
		FHA	407..513	CDD:238017	22/114 (19%)
		FHA	<424..509	CDD:224630	17/93 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..623		8/62 (13%)
		G-patch	617..658	CDD:279867	17/41 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..711
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030