DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Son and SON

DIOPT Version :9

Sequence 1:	NP_001262426.1	Gene:	Son / 41159	FlyBaseID:	FBgn0037716	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	NP_620305.3	Gene:	SON / 6651	HGNCID:	11183	Length:	2426	Species:	Homo sapiens

Alignment Length:	974	Identity:	260/974 - (26%)
Similarity:	393/974 - (40%)	Gaps:	317/974 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TENTEKGASVETPQVAGSQTNPPVQEPLALTKIPPIKVKSERPDAEVEAKLRAMNAKIKAEMVTL 66
            |::||....:.|....||                         :|::|..|.|.:       :.|
Human  1634 TQDTEHDMVISTSPSGGS-------------------------EADIEGPLPAKD-------IHL 1666

  Fly    67 MRRSNSNELGNNDESGESESSASADDKKNIKPVKSSNEILAELFGVFNAA--------PPEELLD 123
            ...||:|.:              :.|.:...|||.|::.||.|.....::        ||:|.|.
Human  1667 DLPSNNNLV--------------SKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLP 1717

  Fly   124 DNLF------------------KKKKKVKKEK-------------KDKKAKKKKTTKSDGECSDS 157
            |:.|                  |..:::...:             :|:.|.....:......|:|
Human  1718 DSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASES 1782

  Fly   158 EAEGKHKH-----------KRKKHKHKDIRVKDKEKD---RDRDK----SKEKDRDRVTDKSKEK 204
            .:|.|..:           |.||:|::|...|:|::|   |.|.|    |:.|.|.| |.:|:.:
Human  1783 SSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKR-TSESRSR 1846

  Fly   205 DRDRDRDRDKSKDKFTAAQAPSEKEKEKSESRKRSAVEPSSHSEKRERHEREKHRDWEREREREK 269
            .|.|. .:.||....|.:::.|.:.:..|.||.:|....|...|||:|  ..|||...|||:|::
Human  1847 ARKRS-SKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKR--SPKHRSKSRERKRKR 1908

  Fly   270 EHERE-----RVRS---------------NNSFYNGQREADRLKGSESASTKSRQEQDLSDISLS 314
            ...|:     |.||               ..|...|:|.:..:..|..:.|.||:.:..|..|.:
Human  1909 SSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRT 1973

  Fly   315 D----------EESYLREKASNGRRRAHNSFYDEKEELSVSPKRNVRESNT--RRN------RKS 361
            .          ..:..|...:..|||...|.. .:...|:||.| :|.|.|  ||.      |:.
Human  1974 PSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVV-RRRSFSISPVR-LRRSRTPLRRRFSRSPIRRK 2036

  Fly   362 RSRSRDLG--------IDKKRLLEIARRNAINMFKQGTMPGVANM----TAEVKDKVLVKMRYGG 414
            ||||.:.|        :||.:|||||:.||..|..:..:|...|:    ...:::||..|.  ||
Human  2037 RSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKS--GG 2099

  Fly   415 RTIQDLTDFCKKISNGDGLSDLSSEEESDV---------DKNGNAKVFHHPFQLKEREPIVMHIR 470
            .||::||:.||:|:        .|:|:.||         ::......:||||:|.|.:||..::
Human  2100 ATIEELTEKCKQIA--------QSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNL- 2155

  Fly   471 NSTALVPAPPRLDEQTKAITMQFPVSSGQTHRNNEV------WVPVDP-----KDSLVPLPSLPP 524
            |..|..|.||:   ....:|.:||||||..||..|.      ||||:.     ||.
Human  2156 NIAAAKPTPPK---SQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDD--------- 2208

  Fly   525 AKQATNMFKETPKNVFAKSIPLQEQQEPAFKPLGGAVVVPPLAATQLPTVPQSVPPTVPKEFAPP 589
                        .|||:.::|    .||
Human  2209 ------------DNVFSSNLP----SEP------------------------------------- 2220

  Fly   590 AVPFVPEVPIPSTSPVTPMQSASIFPDVTPPSMDVSSIITQRLSAIRRLQENPADSEALKMMYTA 654
                                            :|:|:.:::|..|.:||.||..|.||:.|:..|
Human  2221 --------------------------------VDISTAMSERALAQKRLSENAFDLEAMSMLNRA 2253

  Fly   655 QRNMSSWANSKHLPGQFTGSTGAQVMKAHEL-NSGPQLWVRKDQMTSTKPVTGGMGMALLQKMGW 718
            |..:.:||....:|||||||||.||:...:| |:|.|.|::|||.....|||||||..|::||||
Human  2254 QERIDAWAQLNSIPGQFTGSTGVQVLTQEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGW 2318

  Fly   719 KPGEGLGRCKTGSLQPLLLDVKLDKRGLVSRDDLRPPQMRAPAAQRRNKNMAGPIGAGPCPAVQG 783
            :.|||||:.|.|:.:|:|:|.|.|::|||:..:         .||:|:.|.:.
Human  2319 REGEGLGKNKEGNKEPILVDFKTDRKGLVAVGE---------RAQKRSGNFSA------------ 2362

  Fly   784 AGPGPLASTPLVTQDKHPVCVLNELTSKNKWMPPQYKLRQDIGPAHNRSFLFSVEINGQTFTPD 847
                  |...|  ..||||..|.|:.:|.:|.||::.|..|.||.|.:.|||.|..||....|:
Human  2363 ------AMKDL--SGKHPVSALMEICNKRRWQPPEFLLVHDSGPDHRKHFLFRVLRNGALTRPN 2418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_001262426.1	PHA03247	<455..627	CDD:223021	36/182 (20%)
		G-patch	705..747	CDD:396249	23/41 (56%)
		DSRM_SON-like	798..872	CDD:380699	22/50 (44%)
SON	NP_620305.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..155
		PHA03247	<170..460	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
		PHA03379	<340..673	CDD:223066
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..442
		17 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM	726..895
		MSCRAMM_SdrC	<730..903	CDD:380146
		11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]	912..988
		14 X 6 AA repeats of [ED]-R-S-M-M-S	1006..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1144..1236
		3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]	1147..1179
		rne	<1289..1481	CDD:236766
		4 X 8 AA tandem repeats of V-L-E-SS-[AVT]-VT	1359..1390
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1645..1722		24/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1754..2054		78/305 (26%)
		7 X 7 AA repeats of P-S-R-R-S-R-[TS]	1925..1994		10/68 (15%)
		2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S	1934..2013		15/79 (19%)
		3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R	2013..2039		10/26 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2200..2220		6/44 (14%)
		G-patch	2305..2349	CDD:396249	25/43 (58%)
		DSRM_SF	2369..>2419	CDD:412133	22/50 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151848
Domainoid	1	1.000	61	1.000	Domainoid score	I10569
eggNOG	1	0.900	-	-		E1_2BZCQ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006366
OrthoInspector	1	1.000	-	-		oto91661
orthoMCL	1	0.900	-	-		OOG6_106130
Panther	1	1.100	-	-	LDO	PTHR46528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770