DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Son and Son

DIOPT Version :9

Sequence 1:	NP_001262426.1	Gene:	Son / 41159	FlyBaseID:	FBgn0037716	Length:	874	Species:	Drosophila melanogaster
Sequence 2:	XP_006248126.1	Gene:	Son / 304092	RGDID:	1309013	Length:	2479	Species:	Rattus norvegicus

Alignment Length:	973	Identity:	273/973 - (28%)
Similarity:	413/973 - (42%)	Gaps:	267/973 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TENTEKGASVETPQVAGSQTNPPVQEPLALTKIPPIKVKSERPDAEVEAKLRAMNAKIKA--EMV 64
            |::||....:.|....||:.:  ::.||     |...:..:.|...:..|....:..||.  |.|
  Rat  1656 TQDTEHDMVISTSPSGGSEAD--IEGPL-----PAKDIHLDLPSTNLVCKDVEDSLPIKESDETV 1713

  Fly    65 T--LMRRSNSNE----LGNND---ESGESESSASADDKKNIKPV--KSSNEILAELFGVFNAAPP 118
            |  |..:.:|.:    |.|.:   :||.|.|....::...::|:  |....:.:...|:.....|
  Rat  1714 TVALSPKESSEDTEGPLPNKEIVPDSGYSVSIDEINEADLVRPLLPKDMERLTSLRAGIEGPLLP 1778

  Fly   119 EELLDDNLFKKKKKVKKEKKDKKAKKKKTTKSDGECSDSEAEGKHKH-----------KRKKHKH 172
            .|:               ::||..............|:|.:|.|..:           |.||:|:
  Rat  1779 SEV---------------ERDKSVASPVVISIPERASESSSEEKDDYEIFVKVKDTHEKSKKNKN 1828

  Fly   173 KDIRVKDKEKD---RDRDK----SKEKDRDRVTDKSKEKDRDRDRDRDKSKDKFTAAQAPSEKEK 230
            :|...|:|::|   |.|.|    |:.|.|.| |.:|:.:.|.|. .:.||....|.:::.|.:.:
  Rat  1829 RDKGEKEKKRDSSLRSRSKRSKSSEHKSRKR-TSESRSRARKRS-SKSKSHRSQTRSRSRSRRRR 1891

  Fly   231 EKSESRKRSAVEPSSHSEKRERHEREKHRDWEREREREKEHERE-----RVRS------------ 278
            ..|.||.:|....|...|||:|  ..|||...|||:|::...|:     |.||
  Rat  1892 RSSRSRSKSRGRRSVSKEKRKR--SPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTP 1954

  Fly   279 ---NNSFYNGQREADRLKGSESASTKSRQEQDLSDISLSD----------EESYLREKASNGRRR 330
               ..|...|:|.:..:..|..:.|.||:.:..|..|.:.          ..:..|...:..|||
  Rat  1955 SRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRR 2019

  Fly   331 AHNSFYDEKEELSVSPKRNVRESNT--RRN------RKSRSRSRDLG--------IDKKRLLEIA 379
            ...|.. .:...|:||.| :|.|.|  ||.      |:.||||.:.|        :||.:|||||
  Rat  2020 RSRSVV-RRRSFSISPVR-LRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIA 2082

  Fly   380 RRNAINMFKQGTMPGVANM----TAEVKDKVLVKMRYGGRTIQDLTDFCKKISNGDGLSDLSSEE 440
            :.||..|..:..:|...|:    ...:::||..|.  ||.||::||:.||:|:        .|:|
  Rat  2083 KANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKS--GGATIEELTEKCKQIA--------QSKE 2137

  Fly   441 ESDV---------DKNGNAKVFHHPFQLKEREPIVMHIRNSTALVPAPPRLDEQTKAITMQFPVS 496
            :.||         ::......:||||:|.|.:||..:: |..|..|.||:   ....:|.:||||
  Rat  2138 DDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNL-NIAAAKPTPPK---SQVTLTKEFPVS 2198

  Fly   497 SGQTHRNNEV------WVPV-----DPKDSLVPLPSLPPAKQATNMFKETPKNVFAKSIPLQEQQ 550
            ||..||..|.      ||||     :.||.                     .|||:.|:|    .
  Rat  2199 SGSQHRKKEADSVYGEWVPVEKNGEESKDD---------------------DNVFSSSLP----S 2238

  Fly   551 EPAFKPLGGAVVVPPLAATQLPTVPQSVPPTVPKEFAPPAVPFVPEVPIPSTSPVTPMQSASIFP 615
            ||
  Rat  2239 EP--------------------------------------------------------------- 2240

  Fly   616 DVTPPSMDVSSIITQRLSAIRRLQENPADSEALKMMYTAQRNMSSWANSKHLPGQFTGSTGAQVM 680
                  :|:|:.:::|..|.:||.||..|.||:.|:..||..:.:||....:|||||||||.||:
  Rat  2241 ------VDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVL 2299

  Fly   681 KAHEL-NSGPQLWVRKDQMTSTKPVTGGMGMALLQKMGWKPGEGLGRCKTGSLQPLLLDVKLDKR 744
            ...:| |:|.|.|::|||.....|||||||..|::||||:.|||||:.|.|:.:|:|:|.|.|::
  Rat  2300 TQEQLANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRK 2364

  Fly   745 GLVSRDDLRPPQMRAPAAQRRNKNMAGPIGAGPCPAVQGAGPGPLASTPLVTQDKHPVCVLNELT 809
            |||:..:         .||:|:.|.:.                  |...|  ..||||..|.|:.
  Rat  2365 GLVAVGE---------RAQKRSGNFSA------------------AMKDL--SGKHPVSALMEIC 2400

  Fly   810 SKNKWMPPQYKLRQDIGPAHNRSFLFSVEINGQTFTPDRGSNNKKEAKLNAAALCLRSLGILP 872
            :|.:|.||::.|..|.||.|.:.|||.|.|||..:.|...|.|||.||..||.:.|:::|::|
  Rat  2401 NKRRWQPPEFLLVHDSGPDHRKHFLFRVLINGSAYQPSFASPNKKHAKATAATVVLQAMGLVP 2463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_001262426.1	PHA03247	<455..627	CDD:223021	37/182 (20%)
		G-patch	705..747	CDD:396249	23/41 (56%)
		DSRM_SON-like	798..872	CDD:380699	33/73 (45%)
Son	XP_006248126.1	Forkhead_N	1014..1140	CDD:254796
		G-patch	2325..2368	CDD:279867	24/43 (56%)
		DSRM	2392..2460	CDD:214634	16/67 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345367
Domainoid	1	1.000	61	1.000	Domainoid score	I10265
eggNOG	1	0.900	-	-		E1_2BZCQ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006366
OrthoInspector	1	1.000	-	-		oto98732
orthoMCL	1	0.900	-	-		OOG6_106130
Panther	1	1.100	-	-	LDO	PTHR46528
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740