Protein Alignment Son and Son

DIOPT Version :9

• Sequence 1: NP_001262426.1
• Gene: Son / 41159
• FlyBaseID: FBgn0037716
• Length: 874
• Species: Drosophila melanogaster
• Sequence 2: NP_849211.3
• Gene: Son / 20658
• MGIID: 98353
• Length: 2444
• Species: Mus musculus
• Alignment Length: 943
• Identity: 261/943 - (27%)
• Similarity: 398/943 - (42%)
• Gaps: 264/943 - (27%)

  Fly     2 TENTEKGASVETPQVAGSQTNPPVQEPLALTKIPPIKVKSERPDA-----EVEAKLRAMNAKIKA 61
            |::||....:.|....||:.:  ::.||     |...:..:.|..     :||..| .:....:|
Mouse  1661 TQDTEHDMVISTSPSGGSEAD--IEGPL-----PAKDIHLDLPSTNFVCKDVEDSL-PIKESAQA 1717

  Fly    62 EMVTLMRRSNSNE----LGNNDESGESESSASADDKKN---IKPV--KSSNEILAELFGVFNAAP 117
            ..|.|..:.:|.:    |.|.:...||..|||.|:...   ::|:  |....:.:...|:.....
Mouse  1718 VAVALSPKESSEDTEVPLPNKEIVPESGYSASIDEINEADLVRPLLPKDMERLTSLRAGIEGPLL 1782

  Fly   118 PEELLDDNLFKKKKKVKKEKKDKKAKKKKTTKSDGECSDSEAEGKHKH-----------KRKKHK 171
            ..|:               ::||.|............|:|.:|.|..:           |.||:|
Mouse  1783 ASEV---------------ERDKSAASPVVISIPERASESSSEEKDDYEIFVKVKDTHEKSKKNK 1832

  Fly   172 HKDIRVKDKEKD---RDRDK----SKEKDRDRVTDKSKEKDRDRDRDRDKSKDKFTAAQAPSEKE 229
            ::|...|:|::|   |.|.|    |:.|.|.| |.:|:.:.|.|. .:.||....|.:::.|.:.
Mouse  1833 NRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKR-TSESRSRARKRS-SKSKSHRSQTRSRSRSRRR 1895

  Fly   230 KEKSESRKRSAVEPSSHSEKRERHEREKHRDWEREREREKEHERE-----RVRS----------- 278
            :..|.||.:|....|...|||:|  ..|||...|||:|::...|:     |.||
Mouse  1896 RRSSRSRSKSRGRRSVSKEKRKR--SPKHRSKSRERKRKRSSSRDNRKAARARSRTPSRRSRSHT 1958

  Fly   279 ----NNSFYNGQREADRLKGSESASTKSRQEQDLSDISLS----DEESYLREKASNGRRRAHNSF 335
                ..|...|:|.:..:..|..:.|.||:.:..|..|.:    ......|.:..:.|||:.::.
Mouse  1959 PSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSAV 2023

  Fly   336 YDEKEELSVSPKRNVRESNT--RRN------RKSRSRSRDLG--------IDKKRLLEIARRNAI 384
              .:...|:||.| :|.|.|  ||.      |:.||||.:.|        :||.:|||||:.||.
Mouse  2024 --RRRSFSISPVR-LRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAA 2085

  Fly   385 NMFKQGTMPGVANM----TAEVKDKVLVKMRYGGRTIQDLTDFCKKISNGDGLSDLSSEEESDV- 444
            .|..:..:|...|:    ...:::||..|.  ||.||::||:.||:|:        .|:|:.||
Mouse  2086 AMCAKAGVPLPPNLKPAPPPTIEEKVAKKS--GGATIEELTEKCKQIA--------QSKEDDDVI 2140

  Fly   445 --------DKNGNAKVFHHPFQLKEREPIVMHIRNSTALVPAPPRLDEQTKAITMQFPVSSGQTH 501
                    ::......:||||:|.|.:||..:: |..|..|.||:   ....:|.:||||||..|
Mouse  2141 VNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNL-NIAAAKPTPPK---SQVTLTKEFPVSSGSQH 2201

  Fly   502 RNNEV------WVPV-----DPKDSLVPLPSLPPAKQATNMFKETPKNVFAKSIPLQEQQEPAFK 555
            |..|.      ||||     :.||.                     .|||:.|:|    .||
Mouse  2202 RKKEADSVYGEWVPVEKNGEESKDD---------------------DNVFSSSLP----SEP--- 2238

  Fly   556 PLGGAVVVPPLAATQLPTVPQSVPPTVPKEFAPPAVPFVPEVPIPSTSPVTPMQSASIFPDVTPP 620
                                                                             
Mouse  2239 ----------------------------------------------------------------- 2238

  Fly   621 SMDVSSIITQRLSAIRRLQENPADSEALKMMYTAQRNMSSWANSKHLPGQFTGSTGAQVMKAHEL 685
             :|:|:.:::|..|.:||.||..|.||:.|:..||..:.:||....:|||||||||.||:...:|
Mouse  2239 -VDISTAMSERALAQKRLSENAFDLEAMSMLNRAQERIDAWAQLNSIPGQFTGSTGVQVLTQEQL 2302

  Fly   686 -NSGPQLWVRKDQMTSTKPVTGGMGMALLQKMGWKPGEGLGRCKTGSLQPLLLDVKLDKRGLVSR 749
             |:|.|.|::|||.....|||||||..|::||||:.|||||:.|.|:.:|:|:|.|.|::|||:.
Mouse  2303 ANTGAQAWIKKDQFLRAAPVTGGMGAVLMRKMGWREGEGLGKNKEGNKEPILVDFKTDRKGLVAV 2367

  Fly   750 DDLRPPQMRAPAAQRRNKNMAGPIGAGPCPAVQGAGPGPLASTPLVTQDKHPVCVLNELTSKNKW 814
            .:         .||:|:.|.:.                  |...|  ..||||..|.|:.:|.:|
Mouse  2368 GE---------RAQKRSGNFSA------------------AMKDL--SGKHPVSALMEICNKRRW 2403

  Fly   815 MPPQYKLRQDIGPAHNRSFLFSVEINGQTFTPD 847
            .||::.|..|.||.|.:.|||.|..||..:.|:
Mouse  2404 QPPEFLLVHDSGPDHRKHFLFRVLRNGSPYQPN 2436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_001262426.1	PHA03247	<455..627	CDD:223021	37/182 (20%)
		G-patch	705..747	CDD:396249	23/41 (56%)
		DSRM_SON-like	798..872	CDD:380699	22/50 (44%)
Son	NP_849211.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..58
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..155
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..358
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..468
		13 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM	721..850
		11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]	907..983
		14 X 6 AA repeats of [ED]-R-S-M-M-S	1001..1120
		Forkhead_N	1011..1137	CDD:254796
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1141..1213
		3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]	1141..1173
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1802..2072		90/331 (27%)
		7 X 7 AA repeats of P-S-R-R-S-R-[TS]	1950..2019		19/80 (24%)
		2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S	1959..2030		24/90 (27%)
		3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R	2031..2057		10/25 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2192..2238		7/45 (16%)
		G-patch	2323..2366	CDD:279867	22/43 (51%)
		DSRM	2389..>2426	CDD:238007	12/36 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841972
Domainoid	1	1.000	61	1.000	Domainoid score	I10483
eggNOG	1	0.900	-	-		E1_2BZCQ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006366
OrthoInspector	1	1.000	-	-		oto95243
orthoMCL	1	0.900	-	-		OOG6_106130
Panther	1	1.100	-	-	LDO	PTHR46528
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770