Protein Alignment Son and D1037.1

DIOPT Version :10

• Sequence 1: NP_649914.1
• Gene: Son / 41159
• FlyBaseID: FBgn0037716
• Length: 874
• Species: Drosophila melanogaster
• Sequence 2: NP_491200.1
• Gene: D1037.1 / 171936
• WormBaseID: WBGene00017025
• Length: 786
• Species: Caenorhabditis elegans
• Alignment Length: 889
• Identity: 244/889 - (27%)
• Similarity: 385/889 - (43%)
• Gaps: 222/889 - (24%)

  Fly    92 DKKNIKPVKSSNEILAELFGVFNAAPPEELLDDNLFKKKKKVKKEKK----DKKAKKKKTTKSDG 152
            |.:.|.|...|.:|:            ::||:|        ||..:|    ||.|
 Worm     3 DGEGITPKTCSEDII------------KDLLND--------VKSSEKPFSVDKLA---------- 37

  Fly   153 ECSDSEAEGK-----HKHKRKKHKH--------KDIRVKDKEKDRDRDKSKEKDRDRVTDKSKEK 204
            .|..::..||     |:||.||.|.        ...|.:.:.:.|.|.:|:|:.|.|.:.||:.:
 Worm    38 GCDQTDFVGKRPKKHHRHKSKKSKKVRRRSKTWSSSRSRSRSRSRSRGRSQERRRSRKSRKSRSR 102

  Fly   205 DRDRDRDRDKSKDKFTAA-------QAPSE---KEKE-KSESRKRSA------------------ 240
            .|.:.|:....|.....|       ||||.   |.|| |...||..|
 Worm   103 SRLKHREEKIEKKNLEKAPKNELIPQAPSTENGKPKEFKEPPRKDEADDLPLGADFSTPLVKKET 167

  Fly   241 --------VEPSSHSEKR-ERHEREK----HRDWEREREREKEHERERVRSNNSFYNGQREADRL 292
                    |.|.:.::|. |..|.|:    ..|::.....||..|.:.:..|.:..|.:.|..:.
 Worm   168 KLAISITTVLPKAENKKEVEDGEIEEIAYGDGDFKEPEGIEKNLENKNICENGNLDNSENEKSKE 232

  Fly   293 KGSESASTKSRQEQDLSDISLSDEESYLREKASNGRRRAHNSFYDEKEELSVSPKRNVRESNTRR 357
            |.......|:.:::..|. |.||.......|.|..|.|:.::....:.    ||:|:.|.:.||.
 Worm   233 KDKNRKKEKTERKRKRSH-SSSDRRGRRTSKESRRRSRSRDTHRTRRR----SPERSRRSTETRN 292

  Fly   358 N---------------------RKSRSRSRDLGIDKKRLLEIARRNAINMFKQGTMPGVANMTAE 401
            .                     |:.|||||:: |||::||.||:.....|...|.
 Worm   293 ERPERPSRWRSRSRERKEYDSYRRRRSRSREV-IDKEKLLAIAKTKRAEMMSNGD---------- 346

  Fly   402 VKDKVLVKMRYGGRTIQDLTDFCKKISN----------GDGLSDLSSEEESDVDKNGNAKVFHHP 456
             :|..         :|:|...:|||:..          |..:||..|:.|:        ..:.||
 Worm   347 -RDSA---------SIEDFVTYCKKLQRRQEREKRREAGHDVSDHDSDRET--------VRYKHP 393

  Fly   457 FQLKEREPIVMHIRNSTALVPAPPRL---DEQTK----AITMQFPVSSGQTHRNNEVWVPVDPKD 514
            :.: .:|||.::|..:|:...|...:   :|.|:    .:.:.||||||..|:.|..||||:.:|
 Worm   394 YAM-PKEPIRINIVTATSANLAQKAITGPEEPTQLGAAQLRIVFPVSSGAVHKENAEWVPVEKED 457

  Fly   515 SLVPLPSLPPAKQATNMFKETPKNVFAKSIPLQEQQEPAFKPLGGAVVVPPLAATQLPTVPQSVP 579
              ||.......|:...:.........|:.||:.....|.|.   .:::.||      |..||.:|
 Worm   458 --VPKSCSVEQKKHVALTSLEIDRCRAQGIPVAPAPVPKFL---NSILPPP------PAPPQFLP 511

  Fly   580 -PTVPKEFAPPAVPFVPEVPIPSTSPVTPMQSASIFPD-----VTPPSMDVSSIITQRLSAIRRL 638
             ||  ..|.||..|     |:||...| |.:...|..:     :..|| |:..::.||..|.|::
 Worm   512 NPT--DSFRPPTPP-----PLPSVLYV-PNKDQMILKEPKDIPIPAPS-DIGKVLKQRTEAQRKV 567

  Fly   639 QENPADSEALKMMYTAQRNMSSWANSKHLPGQFTGSTGAQVMKAHELNSGPQ-----LWVRKDQM 698
            ...|.|.:|.:.:..|...:|.||..|.|||::||:||.:::.|.||.  ||     .||:|||.
 Worm   568 LSTPNDFDAHRALREANEQISLWAALKSLPGEYTGTTGLRLLTADELQ--PQNPKYHAWVKKDQF 630

  Fly   699 TSTKPVTGGMGMALLQKMGWKPGEGLGRCKTGSLQPLLLDVKLDKRGLVSRDDLRPPQMRAPAAQ 763
            .:..|.|||:|..:|:||||:||||||:..||:|:||:||||.|::||::.:::        :.:
 Worm   631 RNAAPATGGIGRLMLEKMGWRPGEGLGKDATGNLEPLMLDVKSDRKGLIAEEEM--------SIK 687

  Fly   764 RRNKNMAGPIGAGPCPAVQGAGPGPLASTPLVTQDKHPVCVLNELTSKNKWMPPQYKLRQDIGPA 828
            :|||..|                  ..:.|:...:|:|:.::.||.:|.:|.||.:.. ::.|..
 Worm   688 QRNKINA------------------QNNVPVDLSNKNPISLIMELCAKRRWNPPSFSC-EESGAD 733

  Fly   829 HNRSFLFSVEINGQTFTPDRGSNNKKEAKLNAAALCLRSLGILP 872
            |.:.|::::.||...:.|..||..|||.|..||.:.|:|||:||
 Worm   734 HLKMFVWTIVINDVEYRPMCGSKQKKEGKAVAAQVALQSLGVLP 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Son	NP_649914.1	PHA03247	<455..627	CDD:223021	52/184 (28%)
		G-patch	705..747	CDD:396249	26/41 (63%)
		DSRM_SON-like	798..872	CDD:380699	26/73 (36%)
D1037.1	NP_491200.1	G-patch	637..681	CDD:396249	27/43 (63%)
		DSRM_SON-like	704..777	CDD:380699	26/73 (36%)