Protein Alignment Kap-alpha3 and Kpna2

DIOPT Version :10

• Sequence 1: NP_731377.1
• Gene: Kap-alpha3 / 41158
• FlyBaseID: FBgn0027338
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_445935.2
• Gene: Kpna2 / 85245
• RGDID: 621419
• Length: 529
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 262/525 - (49%)
• Similarity: 359/525 - (68%)
• Gaps: 26/525 - (4%)

  Fly     8 RLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPN--------LDSNTDEEEQLSSS 64
            ||..|||||||..||||||.||.|||||.|:::.:||||||.:        |..|.:.:..::.|
  Rat    13 RLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWS 77

  Fly    65 I-DLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTMLQF 128
            : |:.|    ..::...|.||.|.||||||||.:|.|||:::|::.::|..|..|.:.:.:.:||
  Rat    78 VEDIVK----GINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQF 138

  Fly   129 EAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVIKH 193
            |:||||||||||||.||..||..||:|.|:.||.||..::.||||||||||.|||.:.||.||||
  Rat   139 ESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKH 203

  Fly   194 GVVQPLLSFIK-PD---IPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNIL 254
            |.:.|||:.:. ||   :...:|||:||.:.||||||:||||...:.:|||.|..|:||.|..:|
  Rat   204 GAIDPLLALLAVPDLSSLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVL 268

  Fly   255 VDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLN 319
            .|:.|||||||||.|::|:||::.||||:|:.|||.:|:.:.|.||||:||||||:|||||.|::
  Rat   269 ADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVID 333

  Fly   320 YDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAA 384
            ..||:.||.||::||..|:|||.|.:||||||.|.|:|.|:|.||:|.::..|||.:|:||||||
  Rat   334 AGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAA 398

  Fly   385 WAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD--SHVEAVANC 447
            |||:|.|..|..||:..|:..|:|.|..:|||.:||::|.|:||.::|:.:.|:  ...|.::..
  Rat   399 WAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIM 463

  Fly   448 IEECEGLAKIERLQSHENVEIYKLAYEIIDQYFT-DEGEQTNMAP--TSDGAQYNFDPHADRLTM 509
            ||||.||.|||.||||||..:||.:..:|::||: :|.|..|:.|  ||:|..:.....|.
  Rat   464 IEECGGLDKIEALQSHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAP---- 524

  Fly   510 NSFNF 514
            .:|||
  Rat   525 GTFNF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_731377.1	SRP1	8..500	CDD:227396	258/509 (51%)
		armadillo repeat	104..137	CDD:293788	12/32 (38%)
		armadillo repeat	145..181	CDD:293788	21/35 (60%)
		armadillo repeat	187..222	CDD:293788	17/38 (45%)
		armadillo repeat	239..264	CDD:293788	13/24 (54%)
		armadillo repeat	272..308	CDD:293788	20/35 (57%)
		armadillo repeat	314..348	CDD:293788	17/33 (52%)
		armadillo repeat	356..390	CDD:293788	19/33 (58%)
		armadillo repeat	399..433	CDD:293788	13/33 (39%)
Kpna2	NP_445935.2	SRP1	12..528	CDD:227396	259/522 (50%)
		armadillo repeat	115..147	CDD:293788	12/31 (39%)
		armadillo repeat	155..191	CDD:293788	21/35 (60%)
		armadillo repeat	197..236	CDD:293788	17/38 (45%)
		armadillo repeat	253..278	CDD:293788	13/24 (54%)
		armadillo repeat	288..320	CDD:293788	17/31 (55%)
		armadillo repeat	328..364	CDD:293788	19/35 (54%)
		armadillo repeat	370..404	CDD:293788	19/33 (58%)
		armadillo repeat	413..447	CDD:293788	13/33 (39%)
		HEAT repeat	457..494	CDD:293787	19/36 (53%)