DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha3 and IMPA-1

DIOPT Version :9

Sequence 1:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_187328.1	Gene:	IMPA-1 / 819857	AraportID:	AT3G06720	Length:	532	Species:	Arabidopsis thaliana

Alignment Length:	530	Identity:	232/530 - (43%)
Similarity:	325/530 - (61%)	Gaps:	24/530 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TSMEQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEEEQLSSSID 66
            |.:.:||.:    ...|.:|.||||.:..||:||:||||:::|:|. ..:.:........::|:|
plant     9 TEVRRNRYK----VAVDAEEGRRRREDNMVEIRKSKREESLMKKRR-EGMQALQGFPSASAASVD 68

  Fly    67 LKKLAK-----AAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTML 126
             |||..     |...:..|..||.:....|||||.:::|||.::|.:.::|..||.||:.::..:
plant    69 -KKLDSLKDMVAGVWSDDPALQLESTTQFRKLLSIERSPPIEEVISAGVVPRFVEFLKKEDYPAI 132

  Fly   127 QFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVI 191
            ||||||||||||||||..|..|:...|||:|:|||.||:.:|.|||||||||:.||.|..||.|:
plant   133 QFEAAWALTNIASGTSDHTKVVIDHNAVPIFVQLLASPSDDVREQAVWALGNVAGDSPRCRDLVL 197

  Fly   192 KHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVD 256
            ..|.:.|||:.:.....::.|||.||.:.|.||.| |.|....:...||||..|||..|..:|.|
plant   198 GCGALLPLLNQLNEHAKLSMLRNATWTLSNFCRGK-PQPHFDQVKPALPALERLIHSDDEEVLTD 261

  Fly   257 TVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYD 321
            ..||:|||:||.||:||.||::||||||:.||.:....|...|||.|||||||.|.|||.|:|..
plant   262 ACWALSYLSDGTNDKIQTVIQAGVVPKLVELLLHHSPSVLIPALRTVGNIVTGDDIQTQCVINSG 326

  Fly   322 ALSYFPGLLS-HPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAW 385
            ||.....||: :.|:.|:|||.|.:|||||||:.|:|.|:...|:..::..|...||..:|||||
plant   327 ALPCLANLLTQNHKKSIKKEACWTISNITAGNKDQIQTVVEANLISPLVSLLQNAEFDIKKEAAW 391

  Fly   386 AISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSH--------VE 442
            ||||.|..|:.:|:..|:::|.|.|.||||.|.|.::|.|.|:||.|:|||.::.        :.
plant   392 AISNATSGGSHDQIKYLVEQGCIKPLCDLLVCPDPRIITVCLEGLENILKVGEAEKNLGHTGDMN 456

  Fly   443 AVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYF-TDEGEQTNMAPTSDGAQ--YNFDPHA 504
            ..|..|::.|||.|||.||||:|.|||:.|.:|::.|: .:|.::|...|..||:|  :.|..:.
plant   457 YYAQLIDDAEGLEKIENLQSHDNNEIYEKAVKILETYWLEEEDDETQQPPGVDGSQAGFQFGGNQ 521

  Fly   505 DRLTMNSFNF 514
            ..:....|||
plant   522 APVPSGGFNF 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	27/85 (32%)
		SRP1	8..500	CDD:227396	226/508 (44%)
		ARM	104..224	CDD:237987	59/119 (50%)
		armadillo repeat	104..137	CDD:293788	15/32 (47%)
		armadillo repeat	145..181	CDD:293788	21/35 (60%)
		armadillo repeat	187..222	CDD:293788	12/34 (35%)
		ARM	236..350	CDD:237987	61/114 (54%)
		armadillo repeat	239..264	CDD:293788	13/24 (54%)
		armadillo repeat	272..308	CDD:293788	20/35 (57%)
		armadillo repeat	314..348	CDD:293788	15/34 (44%)
		ARM	315..433	CDD:237987	54/118 (46%)
		armadillo repeat	356..390	CDD:293788	14/33 (42%)
		armadillo repeat	399..433	CDD:293788	15/33 (45%)
		Arm_3	442..485	CDD:292804	20/43 (47%)
IMPA-1	NP_187328.1	SRP1	10..530	CDD:227396	228/526 (43%)
		armadillo repeat	111..143	CDD:293788	15/31 (48%)
		armadillo repeat	151..187	CDD:293788	21/35 (60%)
		armadillo repeat	193..227	CDD:293788	12/33 (36%)
		armadillo repeat	244..269	CDD:293788	13/24 (54%)
		armadillo repeat	277..313	CDD:293788	20/35 (57%)
		armadillo repeat	319..354	CDD:293788	15/34 (44%)
		armadillo repeat	362..398	CDD:293788	15/35 (43%)
		armadillo repeat	405..439	CDD:293788	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	47	1.000	Domainoid score	I4518
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930