Protein Alignment Kap-alpha3 and kpna5

DIOPT Version :10

• Sequence 1: NP_731377.1
• Gene: Kap-alpha3 / 41158
• FlyBaseID: FBgn0027338
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_001018163.1
• Gene: kpna5 / 553205
• ZFINID: ZDB-GENE-050522-22
• Length: 539
• Species: Danio rerio
• Alignment Length: 515
• Identity: 237/515 - (46%)
• Similarity: 326/515 - (63%)
• Gaps: 22/515 - (4%)

  Fly     8 RLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNV---PNLDSNTD---EEEQLSSSID 66
            |::::|||..:..||||||.|..::|||.||||.:.|||||   |..:|..:   ::..:||::.
Zfish    13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPPGDESMLECPIQDPDVSSTVP 77

  Fly    67 LKKLAKAAADATK------PEQQLAAVQAARKLLSSDKNPPINDLIQS-DILPILVECLKQHNHT 124
            :........|..:      |:|||.|.|..|||||.:.||||:::|.: .::...||.|::.::.
Zfish    78 VSGEGVITQDVIQMIFSEDPDQQLIATQKFRKLLSKEPNPPIDEVIGTPGVVNRFVEFLRRSDNC 142

  Fly   125 MLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDF 189
            .||||||||||||||||...|..|:..||||:|::||||...:|.||||||||||.||....||:
Zfish   143 TLQFEAAWALTNIASGTFQHTKVVIETGAVPIFIELLNSEYEDVQEQAVWALGNIAGDNAECRDY 207

  Fly   190 VIKHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNIL 254
            |:..|::..|...:.....:|..||..|.:.||||.|:|.|..|.:...|..|:.|:..:|.::|
Zfish   208 VLNCGILPSLQQLLAKSNRLTTTRNAVWALSNLCRGKNPPPDFAKVSPCLSVLSRLLFSSDPDVL 272

  Fly   255 VDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLN 319
            .|..||:|||:||.||:||.||:|||..:|:.||.:|:.||.:.|||||||||||.|.||||:||
Zfish   273 ADACWALSYLSDGPNDKIQTVIDSGVCRRLVELLMHSDYKVVSPALRAVGNIVTGDDIQTQVILN 337

  Fly   320 YDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAA 384
            ..||.....|||.|||.|:|||.|.:|||||||::|:||||:..:.|.:||.|.|.||:|:||||
Zfish   338 CSALPCLLHLLSSPKESIKKEACWTVSNITAGNRAQIQAVIDSNVFPVLIEILQKAEFRTRKEAA 402

  Fly   385 WAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSH-------VE 442
            |||:|.|..|..||:..|:....|.|.||||:..|::::.|.|:||.|:|::.:..       :.
Zfish   403 WAITNATSGGTPEQIRYLVSLNTIKPMCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGTGIN 467

  Fly   443 AVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSD--GAQYNF 500
            .....|||..||.|||.||||||.|||:.|:::|:.||..|.|..::.|..|  ..||.|
Zfish   468 PYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEEEDASIVPQVDQNQGQYIF 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_731377.1	SRP1	8..500	CDD:227396	236/513 (46%)
		armadillo repeat	104..137	CDD:293788	14/33 (42%)
		armadillo repeat	145..181	CDD:293788	22/35 (63%)
		armadillo repeat	187..222	CDD:293788	9/34 (26%)
		armadillo repeat	239..264	CDD:293788	9/24 (38%)
		armadillo repeat	272..308	CDD:293788	21/35 (60%)
		armadillo repeat	314..348	CDD:293788	19/33 (58%)
		armadillo repeat	356..390	CDD:293788	19/33 (58%)
		armadillo repeat	399..433	CDD:293788	12/33 (36%)
kpna5	NP_001018163.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		13/27 (48%)
		SRP1	36..521	CDD:227396	223/484 (46%)
		HEAT repeat	88..117	CDD:293787	11/28 (39%)
		ARM 1. /evidence=ECO:0000255	117..157		19/39 (49%)
		armadillo repeat	129..155	CDD:293788	13/25 (52%)
		ARM 2. /evidence=ECO:0000255	160..199		22/38 (58%)
		armadillo repeat	163..199	CDD:293788	22/35 (63%)
		ARM 3. /evidence=ECO:0000255	202..242		11/39 (28%)
		armadillo repeat	205..240	CDD:293788	9/34 (26%)
		ARM 4. /evidence=ECO:0000255	245..284		14/38 (37%)
		armadillo repeat	257..282	CDD:293788	9/24 (38%)
		ARM 5. /evidence=ECO:0000255	287..326		23/38 (61%)
		armadillo repeat	290..326	CDD:293788	21/35 (60%)
		ARM 6. /evidence=ECO:0000255	329..368		23/38 (61%)
		armadillo repeat	332..366	CDD:293788	19/33 (58%)
		ARM 7. /evidence=ECO:0000255	371..410		21/38 (55%)
		armadillo repeat	374..410	CDD:293788	20/35 (57%)
		ARM 8. /evidence=ECO:0000255	414..453		15/38 (39%)
		armadillo repeat	417..451	CDD:293788	12/33 (36%)