DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha3 and kpna7

DIOPT Version :9

Sequence 1:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_998235.1	Gene:	kpna7 / 406343	ZFINID:	ZDB-GENE-040426-2023	Length:	520	Species:	Danio rerio

Alignment Length:	508	Identity:	221/508 - (43%)
Similarity:	331/508 - (65%)	Gaps:	15/508 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SMEQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNL--------DSNTDEEE 59
            ::...|:..||||||:..::|.||....||.||.:|.|.|:||||:.:|        :.|||.|:
Zfish     5 NLSDKRMSKFKNKGKEPTKLRDRRVAECVEFRKAQRVEGIMKRRNITSLGDEEPLSPEFNTDNEQ 69

  Fly    60 QLSSSIDLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHT 124
            .:.::|: :.:|....|.  ||:|....||||||||.::|||:.::|::.:|...||.|.:::..
Zfish    70 VICTTIE-EIVANVNTDC--PEKQRNGCQAARKLLSRERNPPLKEIIEAGLLTRFVEFLGRNDDP 131

  Fly   125 MLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDF 189
            .|||||||:|||:|||||..|.:||..||||.|:.||.||..|:.||||||||||.|||...||.
Zfish   132 TLQFEAAWSLTNVASGTSWHTQQVVEHGAVPAFIALLASPMLNISEQAVWALGNIAGDGSSYRDA 196

  Fly   190 VIKHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNIL 254
            :|..||:..||:.:.||.|:.:|||:||.:.||||||:|.|..:.:.::||::..|:||:|.:||
Zfish   197 LIDCGVIPALLARLTPDAPVGYLRNLTWTLSNLCRNKNPFPRFSAVQQMLPSIIQLLHHSDKSIL 261

  Fly   255 VDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLN 319
            .|..|||||||||.|::|.::|::|::.:|:.|||..|:.|.|.|||::.|||:|||.|||..::
Zfish   262 SDACWAISYLTDGPNERIDVIIKAGILTRLVELLGFEELAVVTPALRSIENIVSGSDLQTQAAID 326

  Fly   320 YDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAA 384
            ...||..|.|:.|.|..::|||.|.:|||.||...|:|.:|..||...:::.|..|:|:||:||.
Zfish   327 AGVLSALPKLMRHQKSSVQKEAAWAVSNIAAGPCQQIQQLITCGLSAPLVDLLRNGDFKTQREAV 391

  Fly   385 WAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD--SHVEAVANC 447
            ||::|.|..|..|||..|:|.|.:....:||..:||:.:.|:||.::|:...|:  ..|:.:...
Zfish   392 WAVTNYTSGGTVEQVVHLVKCGALEAILNLLQVKDTKTVLVILDAISNIFLAAEKLGEVDKLCLL 456

  Fly   448 IEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSDGAQYNF 500
            :||..||.:||..|:|||..:|:.|..:|::||:::||  :...|::....||
Zfish   457 VEEVGGLDRIEFFQNHENNAVYRAAQALIEKYFSEDGE--DQCLTTEATDANF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	32/88 (36%)
		SRP1	8..500	CDD:227396	219/501 (44%)
		ARM	104..224	CDD:237987	63/119 (53%)
		armadillo repeat	104..137	CDD:293788	14/32 (44%)
		armadillo repeat	145..181	CDD:293788	23/35 (66%)
		armadillo repeat	187..222	CDD:293788	15/34 (44%)
		ARM	236..350	CDD:237987	54/113 (48%)
		armadillo repeat	239..264	CDD:293788	13/24 (54%)
		armadillo repeat	272..308	CDD:293788	15/35 (43%)
		armadillo repeat	314..348	CDD:293788	13/33 (39%)
		ARM	315..433	CDD:237987	46/117 (39%)
		armadillo repeat	356..390	CDD:293788	13/33 (39%)
		armadillo repeat	399..433	CDD:293788	11/33 (33%)
		Arm_3	442..485	CDD:292804	15/42 (36%)
kpna7	NP_998235.1	SRP1	1..520	CDD:227396	221/508 (44%)
		IBB	10..90	CDD:280005	31/82 (38%)
		ARM	111..231	CDD:237987	63/119 (53%)
		armadillo repeat	112..144	CDD:293788	14/31 (45%)
		armadillo repeat	152..188	CDD:293788	23/35 (66%)
		armadillo repeat	194..229	CDD:293788	15/34 (44%)
		ARM	246..357	CDD:237987	54/110 (49%)
		armadillo repeat	246..271	CDD:293788	13/24 (54%)
		armadillo repeat	279..315	CDD:293788	15/35 (43%)
		armadillo repeat	321..355	CDD:293788	13/33 (39%)
		ARM	322..441	CDD:237987	47/118 (40%)
		armadillo repeat	363..399	CDD:293788	14/35 (40%)
		armadillo repeat	406..440	CDD:293788	11/33 (33%)
		Arm_3	451..495	CDD:292804	17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830