DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha3 and KPNA3

DIOPT Version :9

Sequence 1:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_002258.2	Gene:	KPNA3 / 3839	HGNCID:	6396	Length:	521	Species:	Homo sapiens

Alignment Length:	518	Identity:	352/518 - (67%)
Similarity:	416/518 - (80%)	Gaps:	8/518 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SMEQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEE---EQLSSS 64
            |:|.:|:::|||||:|.:.|||.|||||||||||||:|.:||:||||..:|..|.:   :..:.:
Human     6 SLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQN 70

  Fly    65 IDLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTMLQFE 129
            :.|:.:.:.|. :..|..||:||||||||||||:||||:|||:|.||||||:||::.::..||||
Human    71 VTLEAILQNAT-SDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFE 134

  Fly   130 AAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVIKHG 194
            ||||||||||||||||..||.:.||||||:||.||..||||||||||||||||||..||:||..|
Human   135 AAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVISLG 199

  Fly   195 VVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVW 259
            ||:||||||.|.||||||||||||||||||||||.||..|:.||||||.|||:|||.||||||||
Human   200 VVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVW 264

  Fly   260 AISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALS 324
            |:||||||||:||||||:|||||.|:|||.:.||||||||||||||||||:|||||||||.|.||
Human   265 ALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLS 329

  Fly   325 YFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISN 389
            :||.|||||||||.|||||||||||||||.||||||:.||:|.||..|:||:|.|||||||||||
Human   330 HFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISN 394

  Fly   390 LTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGL 454
            |||||.::||..|:::.||||||:|||.:|:||:.||||||.|:|.:|......:|..||||.||
Human   395 LTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGL 459

  Fly   455 AKIERLQSHENVEIYKLAYEIIDQYFT--DEGEQTNMAP-TSDGAQYNFDPHADRLTMNSFNF 514
            .|||.||.|||.:|||||:|||||||:  |..|...:.| .:.|..|||||.|: |....|||
Human   460 EKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNFDPTAN-LQTKEFNF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	38/83 (46%)
		SRP1	8..500	CDD:227396	341/497 (69%)
		ARM	104..224	CDD:237987	92/119 (77%)
		armadillo repeat	104..137	CDD:293788	22/32 (69%)
		armadillo repeat	145..181	CDD:293788	26/35 (74%)
		armadillo repeat	187..222	CDD:293788	28/34 (82%)
		ARM	236..350	CDD:237987	95/113 (84%)
		armadillo repeat	239..264	CDD:293788	20/24 (83%)
		armadillo repeat	272..308	CDD:293788	29/35 (83%)
		armadillo repeat	314..348	CDD:293788	28/33 (85%)
		ARM	315..433	CDD:237987	86/117 (74%)
		armadillo repeat	356..390	CDD:293788	24/33 (73%)
		armadillo repeat	399..433	CDD:293788	20/33 (61%)
		Arm_3	442..485	CDD:292804	28/44 (64%)
KPNA3	NP_002258.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		12/22 (55%)
		SRP1	2..521	CDD:227396	350/516 (68%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		5/8 (63%)
		ARM 1, truncated	66..106		18/40 (45%)
		armadillo repeat	73..98	CDD:293788	11/25 (44%)
		ARM 2	107..149		30/41 (73%)
		armadillo repeat	109..142	CDD:293788	22/32 (69%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		74/91 (81%)
		armadillo repeat	150..186	CDD:293788	26/35 (74%)
		armadillo repeat	192..227	CDD:293788	28/34 (82%)
		ARM 4	195..233		32/37 (86%)
		ARM 5	234..278		33/43 (77%)
		armadillo repeat	244..269	CDD:293788	20/24 (83%)
		armadillo repeat	277..313	CDD:293788	29/35 (83%)
		ARM 6	279..318		31/38 (82%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		71/87 (82%)
		armadillo repeat	319..353	CDD:293788	28/33 (85%)
		ARM 8	361..400		29/38 (76%)
		armadillo repeat	361..395	CDD:293788	24/33 (73%)
		ARM 9	401..443		23/41 (56%)
		armadillo repeat	404..438	CDD:293788	20/33 (61%)
		ARM 10, atypical	447..485		25/37 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143888
Domainoid	1	1.000	76	1.000	Domainoid score	I8982
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	676	1.000	Inparanoid score	I726
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	1	1.000	-	-		otm40373
orthoMCL	1	0.900	-	-		OOG6_104544
Panther	1	1.100	-	-	LDO	PTHR23316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2158
SonicParanoid	1	1.000	-	-		X2405
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800