DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kap-alpha3 and KPNA1

DIOPT Version :10

Sequence 1:NP_731377.1 Gene:Kap-alpha3 / 41158 FlyBaseID:FBgn0027338 Length:514 Species:Drosophila melanogaster
Sequence 2:NP_002255.3 Gene:KPNA1 / 3836 HGNCID:6394 Length:538 Species:Homo sapiens


Alignment Length:522 Identity:245/522 - (46%)
Similarity:335/522 - (64%) Gaps:28/522 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEE--------EQL 61
            |..||:::|||..:.|||||||.|..::|||.||||.:.|||||...:..|:||        |..
Human     7 ENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQ 71

  Fly    62 SSSIDLKKLAKAAAD------ATKPEQQLAAVQAARKLLSSDKNPPINDLIQS-DILPILVECLK 119
            .|::::.......:|      :..|||||:|.|..|||||.:.||||:::|.: .::...||.||
Human    72 ISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLK 136

  Fly   120 QHNHTMLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGP 184
            :..:..||||:||.|||||||.|.||..|:.|||||:|::||:|...:|.||||||||||.||..
Human   137 RKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDST 201

  Fly   185 LLRDFVIKHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHT 249
            :.||:|:...::.|||........:|..||..|.:.||||.|.|.|..|.:...|..|:.|:..:
Human   202 MCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVS 266

  Fly   250 DTNILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQT 314
            ||::|.|..||:|||:||.||:||.||::||..:|:.||.:::.||.:.|||||||||||.|.||
Human   267 DTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQT 331

  Fly   315 QVVLNYDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQT 379
            ||:||..||.....|||.|||.|:|||.|.:|||||||::|:|.||:..:.|.:|..|...||:|
Human   332 QVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRT 396

  Fly   380 QKEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAV 444
            :|||||||:|.|..|:.||:..|::.|.|.|.||||:..|::::.|.|:||.|:|::.:.  ||.
Human   397 RKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQ--EAK 459

  Fly   445 AN-------C--IEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSD--GAQY 498
            .|       |  |||..||.|||.||||||.|||:.|:::|:.||..|.|.:::||..|  ..||
Human   460 RNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQY 524

  Fly   499 NF 500
            .|
Human   525 IF 526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kap-alpha3NP_731377.1 SRP1 8..500 CDD:227396 243/517 (47%)
armadillo repeat 104..137 CDD:293788 13/33 (39%)
armadillo repeat 145..181 CDD:293788 22/35 (63%)
armadillo repeat 187..222 CDD:293788 10/34 (29%)
armadillo repeat 239..264 CDD:293788 10/24 (42%)
armadillo repeat 272..308 CDD:293788 19/35 (54%)
armadillo repeat 314..348 CDD:293788 19/33 (58%)
armadillo repeat 356..390 CDD:293788 16/33 (48%)
armadillo repeat 399..433 CDD:293788 13/33 (39%)
KPNA1NP_002255.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 14/28 (50%)
SRP1 33..516 CDD:227396 226/484 (47%)
nuclear localization signal 42..51 5/8 (63%)
ARM 1, truncated 77..117 14/39 (36%)
ARM 2 118..161 20/42 (48%)
armadillo repeat 128..154 CDD:293788 12/25 (48%)
NLS binding site (major). /evidence=ECO:0000250|UniProtKB:P52293 149..241 46/91 (51%)
armadillo repeat 162..198 CDD:293788 22/35 (63%)
armadillo repeat 204..239 CDD:293788 10/34 (29%)
ARM 4 207..245 13/37 (35%)
Binding to RAG1. /evidence=ECO:0000269|PubMed:8052633 245..437 98/191 (51%)
armadillo repeat 256..281 CDD:293788 10/24 (42%)
armadillo repeat 289..325 CDD:293788 19/35 (54%)
NLS binding site (minor). /evidence=ECO:0000250|UniProtKB:P52293 318..406 53/87 (61%)
armadillo repeat 373..409 CDD:293788 17/35 (49%)
ARM 9 413..457 17/45 (38%)
armadillo repeat 416..450 CDD:293788 13/33 (39%)
ARM 10, atypical 460..504 21/43 (49%)

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