DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha3 and cut15

DIOPT Version :9

Sequence 1:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_587868.1	Gene:	cut15 / 2539426	PomBaseID:	SPCC962.03c	Length:	542	Species:	Schizosaccharomyces pombe

Alignment Length:	522	Identity:	231/522 - (44%)
Similarity:	335/522 - (64%)	Gaps:	24/522 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QNRLQNFKNKGKDQ-DEMRRRRNEVTVELRKNKREETILKRRNVPNLDS--------NTDEEEQL 61
            ::|.||:|.||..| ||:||||....:|:||.||||.:.||||:.::..        ..|:|..|
pombe    10 EHRRQNYKGKGTFQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEETIPLEQDKENDL 74

  Fly    62 SSSIDLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTML 126
            ...:.|..|.||.. :...|.|:.|....||.||.:.||||..:|.:.::|..||.| .|.:.:|
pombe    75 ELELQLPDLLKALY-SDDIEAQIQATAKFRKALSKETNPPIQKVIDAGVVPRFVEFL-SHENNLL 137

  Fly   127 QFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVI 191
            :|||:|||||:|||:|.||:.||.|.|||:|:.||:|...:|.||||||||||.||.|:.||.|:
pombe   138 KFEASWALTNVASGSSNQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVL 202

  Fly   192 KHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVD 256
            :.||::|||:.|:.:..::.|||.||.:.|:||.|:|.|...:|.:::|.|:.||:..|.::|||
pombe   203 QCGVLEPLLNIIESNRRLSMLRNSTWTLSNMCRGKNPQPDWNSISQVIPVLSKLIYTLDEDVLVD 267

  Fly   257 TVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYD 321
            .:||||||:||.|::||.:|::|:..:|:.||.:...:|||.|||:|||||||.|.||||::|..
pombe   268 ALWAISYLSDGANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVTGDDVQTQVIINCG 332

  Fly   322 ALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWA 386
            |||....|||.|::.:||||.|.:|||||||.||:|.||...::|.:|..|:..:|:.||||.||
pombe   333 ALSALLSLLSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWA 397

  Fly   387 ISNLTISGNR--EQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD-------SHVE 442
            |||.|..|.|  :|:..|:::|.|.|.|:||:|||.::|.|.|||:.|:|:|.:       ..:.
pombe   398 ISNATSGGARRPDQIRYLVEQGAIKPLCNLLACQDNKIIQVALDGIENILRVGELDRANNPDKIN 462

  Fly   443 AVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDEGEQTNMAPTSDGAQYNF----DPH 503
            ..|..:|:..|:..|...|:..|.|||:.||.||:::|.:|.|...:.|.:.|..:.|    :|.
pombe   463 LYAVYVEDAGGMDLIHECQNSSNSEIYQKAYNIIEKFFGEEDEIEELEPETVGDTFTFGTTQEPA 527

  Fly   504 AD 505
            .|
pombe   528 GD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	34/89 (38%)
		SRP1	8..500	CDD:227396	228/509 (45%)
		ARM	104..224	CDD:237987	60/119 (50%)
		armadillo repeat	104..137	CDD:293788	14/32 (44%)
		armadillo repeat	145..181	CDD:293788	22/35 (63%)
		armadillo repeat	187..222	CDD:293788	14/34 (41%)
		ARM	236..350	CDD:237987	58/113 (51%)
		armadillo repeat	239..264	CDD:293788	12/24 (50%)
		armadillo repeat	272..308	CDD:293788	17/35 (49%)
		armadillo repeat	314..348	CDD:293788	17/33 (52%)
		ARM	315..433	CDD:237987	59/119 (50%)
		armadillo repeat	356..390	CDD:293788	15/33 (45%)
		armadillo repeat	399..433	CDD:293788	15/33 (45%)
		Arm_3	442..485	CDD:292804	15/42 (36%)
cut15	NP_587868.1	SRP1	3..531	CDD:227396	231/522 (44%)
		IBB	8..99	CDD:280005	33/89 (37%)
		armadillo repeat	73..106	CDD:293788	10/33 (30%)
		ARM	115..235	CDD:237987	60/120 (50%)
		armadillo repeat	116..148	CDD:293788	14/32 (44%)
		armadillo repeat	156..192	CDD:293788	22/35 (63%)
		armadillo repeat	198..233	CDD:293788	14/34 (41%)
		ARM	199..319	CDD:237987	54/119 (45%)
		armadillo repeat	250..275	CDD:293788	12/24 (50%)
		armadillo repeat	283..361	CDD:293788	41/77 (53%)
		ARM	344..446	CDD:237987	50/101 (50%)
		armadillo repeat	367..400	CDD:293788	14/32 (44%)
		armadillo repeat	412..446	CDD:293788	15/33 (45%)
		Arm_3	462..>501	CDD:292804	13/38 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	52	1.000	Domainoid score	I3295
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2158
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.950