DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha3 and ima-2

DIOPT Version :9

Sequence 1:	NP_001163572.1	Gene:	Kap-alpha3 / 41158	FlyBaseID:	FBgn0027338	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_491824.1	Gene:	ima-2 / 172329	WormBaseID:	WBGene00002073	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	188/522 - (36%)
Similarity:	290/522 - (55%)	Gaps:	31/522 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEEEQL-------- 61
            |..|||.:||..| .:|:||||.|.:||:||.|..:.::||||:.::|...:.|.:|
Worm    18 EGGRLQQYKNLTK-HEELRRRRTECSVEIRKQKGADMMMKRRNIVDVDEGGNSESELEEPEKISH 81

  Fly    62 ---SSSIDLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNH 123
               |:.:...::....::....:..:...::.||.||..|||||:::|...:|..||:.|...|.
Worm    82 QQSSTRLSNDEIRAILSNNPSEDDMVRCFESLRKSLSKTKNPPIDEVIHCGLLQALVQALSVENE 146

  Fly   124 TMLQFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRD 188
             .:|:|||||||||.||::.||...|.||.....:.|....:..:.|||:||:.||.||...|||
Worm   147 -RVQYEAAWALTNIVSGSTEQTIAAVEAGVTIPLIHLSVHQSAQISEQALWAVANIAGDSSQLRD 210

  Fly   189 FVIK-HGVVQPLLSFIKPD-IPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDT 251
            :||| |||...:....|.| :..:.:|.:.|...|:||:|:|..|...:..:...|..|:.|||.
Worm   211 YVIKCHGVEALMHLMEKVDQLGDSHVRTIAWAFSNMCRHKNPHAPLEVLRVLSKGLVKLVQHTDR 275

  Fly   252 NILVDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQV 316
            .:..|..||:||||||.::||::..||||:|.::.....:| .:...|||.:||:.||:|..||.
Worm   276 QVRQDACWAVSYLTDGPDEQIELARESGVLPHVVAFFKEAE-NLVAPALRTLGNVATGNDSLTQA 339

  Fly   317 VLNYDALSYFPGLLSHPK-EKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQ 380
            |::..:|.....|:...: ..|.||..|.:|||.||.|.|:|||::..|||.:|..|..|:.:.|
Worm   340 VIDLGSLDEILPLMEKTRSSSIVKECCWLVSNIIAGTQKQIQAVLDANLLPVLINVLKSGDHKCQ 404

  Fly   381 KEAAWAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNN-MLKVADSH---V 441
            .||:||:|||...|...||..::::.|:|..|..|...:|.::|..|:.|.. ||.|.:.:   |
Worm   405 FEASWALSNLAQGGTNRQVVAMLEDNVVPALCQALLQTNTDMLNNTLETLYTLMLTVQNGYPHKV 469

  Fly   442 EAVANCIEECEGLAKIERLQSHENVEIYKLAYEIIDQYFTDE--GEQTNMAPTSDGAQYNFDPHA 504
            :.:.:.:||..||..:||||..::.:||..||.||.|:|||:  ||:.        :..|.||..
Worm   470 DILHDQVEENGGLDSLERLQESQSEQIYTQAYRIITQFFTDDDAGEKE--------SHENADPQD 526

  Fly   505 DR 506
            ::
Worm   527 NK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_001163572.1	IBB	7..88	CDD:280005	25/91 (27%)
		SRP1	8..500	CDD:227396	184/511 (36%)
		ARM	104..224	CDD:237987	47/121 (39%)
		armadillo repeat	104..137	CDD:293788	14/32 (44%)
		armadillo repeat	145..181	CDD:293788	12/35 (34%)
		armadillo repeat	187..222	CDD:293788	12/36 (33%)
		ARM	236..350	CDD:237987	42/114 (37%)
		armadillo repeat	239..264	CDD:293788	9/24 (38%)
		armadillo repeat	272..308	CDD:293788	12/35 (34%)
		armadillo repeat	314..348	CDD:293788	10/34 (29%)
		ARM	315..433	CDD:237987	43/119 (36%)
		armadillo repeat	356..390	CDD:293788	15/33 (45%)
		armadillo repeat	399..433	CDD:293788	9/34 (26%)
		Arm_3	442..485	CDD:292804	18/44 (41%)
ima-2	NP_491824.1	SRP1	21..522	CDD:227396	184/511 (36%)
		IBB	21..103	CDD:280005	25/82 (30%)
		ARM	126..248	CDD:237987	47/122 (39%)
		armadillo repeat	128..159	CDD:293788	14/31 (45%)
		armadillo repeat	167..203	CDD:293788	12/35 (34%)
		armadillo repeat	209..246	CDD:293788	12/36 (33%)
		ARM	266..374	CDD:237987	42/108 (39%)
		armadillo repeat	296..331	CDD:293788	12/35 (34%)
		armadillo repeat	337..372	CDD:293788	10/34 (29%)
		ARM	338..454	CDD:237987	42/115 (37%)
		armadillo repeat	380..416	CDD:293788	17/35 (49%)
		armadillo repeat	423..454	CDD:293788	8/30 (27%)
		Arm_3	470..517	CDD:292804	20/46 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7824
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830