Protein Alignment Kap-alpha3 and Kpna3

DIOPT Version :10

• Sequence 1: NP_731377.1
• Gene: Kap-alpha3 / 41158
• FlyBaseID: FBgn0027338
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: NP_032492.1
• Gene: Kpna3 / 16648
• MGIID: 1100863
• Length: 521
• Species: Mus musculus
• Alignment Length: 517
• Identity: 351/517 - (67%)
• Similarity: 417/517 - (80%)
• Gaps: 8/517 - (1%)

  Fly     4 MEQNRLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEE---EQLSSSI 65
            :|.:|:::|||||:|.:.|||.|||||||||||||:|.:||:||||..:|..|.:   :..:.::
Mouse     7 LENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQNV 71

  Fly    66 DLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTMLQFEA 130
            .|:.:.:.|. :..|..||:||||||||||||:||||:|||:|.||||||:||::.::..|||||
Mouse    72 TLEAILQNAT-SDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQFEA 135

  Fly   131 AWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVIKHGV 195
            |||||||||||||||..||.:.||||||:||:||..||||||||||||||||||..||:||..||
Mouse   136 AWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGV 200

  Fly   196 VQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVDTVWA 260
            |:||||||.|.||||||||||||||||||||||.||..|:.||||||.|||:|||.|||||||||
Mouse   201 VKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWA 265

  Fly   261 ISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYDALSY 325
            :||||||||:||||||:|||||.|:|||.:.||||||||||||||||||:|||||||||.|.||:
Mouse   266 LSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSH 330

  Fly   326 FPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWAISNL 390
            ||.|||||||||.|||||||||||||||.||||||:.||:|.||..|:||:|.||||||||||||
Mouse   331 FPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNL 395

  Fly   391 TISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVADSHVEAVANCIEECEGLA 455
            ||||.::||..|:::.||||||:|||.:|:||:.||||||.|:|.:|......:|..||||.||.
Mouse   396 TISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLE 460

  Fly   456 KIERLQSHENVEIYKLAYEIIDQYFT--DEGEQTNMAP-TSDGAQYNFDPHADRLTMNSFNF 514
            |||.||.|||.:|||||:|||||||:  |..|..::.| .:.|..|||||.|: |....|||
Mouse   461 KIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNFDPTAN-LQTKEFNF 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha3	NP_731377.1	SRP1	8..500	CDD:227396	341/497 (69%)
		armadillo repeat	104..137	CDD:293788	22/32 (69%)
		armadillo repeat	145..181	CDD:293788	26/35 (74%)
		armadillo repeat	187..222	CDD:293788	28/34 (82%)
		armadillo repeat	239..264	CDD:293788	20/24 (83%)
		armadillo repeat	272..308	CDD:293788	29/35 (83%)
		armadillo repeat	314..348	CDD:293788	28/33 (85%)
		armadillo repeat	356..390	CDD:293788	24/33 (73%)
		armadillo repeat	399..433	CDD:293788	20/33 (61%)
Kpna3	NP_032492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		11/21 (52%)
		SRP1	7..521	CDD:227396	349/515 (68%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		5/8 (63%)
		ARM 1, truncated	66..106		18/40 (45%)
		armadillo repeat	73..98	CDD:293788	11/25 (44%)
		ARM 2	107..149		30/41 (73%)
		armadillo repeat	109..142	CDD:293788	22/32 (69%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		74/91 (81%)
		armadillo repeat	150..186	CDD:293788	26/35 (74%)
		armadillo repeat	192..227	CDD:293788	28/34 (82%)
		ARM 4	195..233		32/37 (86%)
		ARM 5	234..278		33/43 (77%)
		armadillo repeat	244..269	CDD:293788	20/24 (83%)
		armadillo repeat	277..313	CDD:293788	29/35 (83%)
		ARM 6	279..318		31/38 (82%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		71/87 (82%)
		armadillo repeat	319..353	CDD:293788	28/33 (85%)
		ARM 8	361..400		29/38 (76%)
		armadillo repeat	361..395	CDD:293788	24/33 (73%)
		ARM 9	401..443		23/41 (56%)
		armadillo repeat	404..438	CDD:293788	20/33 (61%)
		ARM 10, atypical	447..485		25/37 (68%)