DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kap-alpha3 and Kpna2

DIOPT Version :9

Sequence 1:NP_001163572.1 Gene:Kap-alpha3 / 41158 FlyBaseID:FBgn0027338 Length:514 Species:Drosophila melanogaster
Sequence 2:NP_034785.1 Gene:Kpna2 / 16647 MGIID:103561 Length:529 Species:Mus musculus


Alignment Length:525 Identity:262/525 - (49%)
Similarity:357/525 - (68%) Gaps:26/525 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 RLQNFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPN--------LDSNTDEEEQLSSS 64
            ||..|||||||..||||||.||.|||||.|::|.:||||||.:        |..|.:.:..::.|
Mouse    13 RLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNWS 77

  Fly    65 I-DLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTMLQF 128
            : |:.|    ..::...|.||.|.||||||||.:|.|||:::|::.::|..|..|.:.:.:.:||
Mouse    78 VEDIVK----GINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQF 138

  Fly   129 EAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVIKH 193
            |:||||||||||||.||..||..||:|.|:.||.||..::.||||||||||.|||...||.||||
Mouse   139 ESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKH 203

  Fly   194 GVVQPLLSFIK-PDIPIT---FLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNIL 254
            |.:.|||:.:. ||:...   :|||:||.:.||||||:||||...:.:|||.|..|:||.|..:|
Mouse   204 GAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVL 268

  Fly   255 VDTVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLN 319
            .|:.|||||||||.|::|:||::.||||:|:.|||.:|:.:.|.||||:||||||:|||||.|::
Mouse   269 ADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVID 333

  Fly   320 YDALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAA 384
            ..||:.||.||::||..|:|||.|.:||||||.|.|:|.|:|.||:|.::..|||.:|:||||||
Mouse   334 AGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAA 398

  Fly   385 WAISNLTISGNREQVFTLIKEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD--SHVEAVANC 447
            |||:|.|..|..||:..|:..|:|.|..:|||.:||::|.|:||.::|:.:.|:  ...|.::..
Mouse   399 WAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIM 463

  Fly   448 IEECEGLAKIERLQSHENVEIYKLAYEIIDQYFT-DEGEQTNMAP--TSDGAQYNFDPHADRLTM 509
            ||||.||.|||.||.|||..:||.:..:|::||: :|.|..|:.|  ||:|..:.....|.    
Mouse   464 IEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAP---- 524

  Fly   510 NSFNF 514
            .:|||
Mouse   525 GTFNF 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kap-alpha3NP_001163572.1 IBB 7..88 CDD:280005 39/88 (44%)
SRP1 8..500 CDD:227396 258/509 (51%)
ARM 104..224 CDD:237987 63/123 (51%)
armadillo repeat 104..137 CDD:293788 12/32 (38%)
armadillo repeat 145..181 CDD:293788 21/35 (60%)
armadillo repeat 187..222 CDD:293788 17/38 (45%)
ARM 236..350 CDD:237987 65/113 (58%)
armadillo repeat 239..264 CDD:293788 13/24 (54%)
armadillo repeat 272..308 CDD:293788 20/35 (57%)
armadillo repeat 314..348 CDD:293788 17/33 (52%)
ARM 315..433 CDD:237987 60/117 (51%)
armadillo repeat 356..390 CDD:293788 19/33 (58%)
armadillo repeat 399..433 CDD:293788 13/33 (39%)
Arm_3 442..485 CDD:292804 21/43 (49%)
Kpna2NP_034785.1 SRP1 9..528 CDD:227396 259/522 (50%)
IBB 10..98 CDD:280005 39/88 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 45..70 9/24 (38%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:10201409, ECO:0000269|PubMed:10764582 45..54 6/8 (75%)
ARM 1, truncated 71..111 16/43 (37%)
ARM 2 112..151 17/38 (45%)
ARM 113..238 CDD:237987 63/124 (51%)
armadillo repeat 115..147 CDD:293788 12/31 (39%)
NLS binding site (major) 142..238 55/95 (58%)
armadillo repeat 155..191 CDD:293788 21/35 (60%)
armadillo repeat 197..236 CDD:293788 17/38 (45%)
ARM 4 200..244 22/43 (51%)
ARM 5 246..282 18/35 (51%)
ARM 252..364 CDD:237987 65/111 (59%)
armadillo repeat 253..278 CDD:293788 13/24 (54%)
ARM 6 283..322 21/38 (55%)
armadillo repeat 288..320 CDD:293788 17/31 (55%)
NLS binding site (minor) 315..403 54/87 (62%)
armadillo repeat 328..364 CDD:293788 19/35 (54%)
ARM 329..449 CDD:237987 61/119 (51%)
ARM 8 367..409 23/41 (56%)
armadillo repeat 370..404 CDD:293788 19/33 (58%)
ARM 9 410..456 17/45 (38%)
armadillo repeat 413..447 CDD:293788 13/33 (39%)
ARM 10, atypical 457..496 18/38 (47%)
HEAT repeat 457..494 CDD:293787 18/36 (50%)
Arm_3 458..508 CDD:292804 23/49 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5064
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54553
OrthoDB 1 1.010 - - D1111872at2759
OrthoFinder 1 1.000 - - FOG0000157
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.830

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