DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16790 and USB1

DIOPT Version :9

Sequence 1:	NP_649911.1	Gene:	CG16790 / 41155	FlyBaseID:	FBgn0037713	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	NP_078874.2	Gene:	USB1 / 79650	HGNCID:	25792	Length:	265	Species:	Homo sapiens

Alignment Length:	272	Identity:	102/272 - (37%)
Similarity:	147/272 - (54%)	Gaps:	35/272 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GSSSSASEDED-----------CTENIQTPALITLKRPALPKAATLLGPKKPKPEEFVEDVVDDP 61
            |.|||.||||.           .....|:|    |.|...|...::|. ..|..||..|   ||.
Human     8 GYSSSGSEDESEDGMRTRPGDGSHRRGQSP----LPRQRFPVPDSVLN-MFPGTEEGPE---DDS 64

  Fly    62 AEHGGRMRSFKHERGNWATYVYVPATACVDQLEEFQTEAIARLEPHLE-----LQPNESLHLSLS 121
            .:||||:|:|.||||||||:||||..|    .||| .:.:..|.||.:     |...:..|||||
Human    65 TKHGGRVRTFPHERGNWATHVYVPYEA----KEEF-LDLLDVLLPHAQTYVPRLVRMKVFHLSLS 124

  Fly   122 RTVVLQYHQIDEFSRSLQSALNSSAGFAATLQGLRIYTNEERTRTFIAAPLDAAFVEKMTAILQP 186
            ::|||::|.|..|.::|::.:.|...|..|...::||||:|:|||||...:.:...:.:. ::..
Human   125 QSVVLRHHWILPFVQALKARMTSFHRFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLD-LVSE 188

  Fly   187 IDQVMLDYRLQQFYDPASFHVSLLWCVGDQETLL-NEKLTELKELLD--DQDKLCLAVN--EVHL 246
            :|:||.::.|..||...|||:||.|||||....| .:.|.||:.::|  :..::.|.|:  :|..
Human   189 VDRVMEEFNLTTFYQDPSFHLSLAWCVGDARLQLEGQCLQELQAIVDGFEDAEVLLRVHTEQVRC 253

  Fly   247 KCGNKDFTYSLK 258
            |.|||.|:..||
Human   254 KSGNKFFSMPLK 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16790	NP_649911.1	HVSL	34..254	CDD:286792	87/229 (38%)
USB1	NP_078874.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		24/71 (34%)
USB1	NP_078874.2	HVSL	44..263	CDD:313045	88/228 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155709
Domainoid	1	1.000	131	1.000	Domainoid score	I5174
eggNOG	1	0.900	-	-		E1_KOG3102
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11611
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4553
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52902
OrthoDB	1	1.010	-	-		D1507496at2759
OrthoFinder	1	1.000	-	-		FOG0007343
OrthoInspector	1	1.000	-	-		oto90572
orthoMCL	1	0.900	-	-		OOG6_103799
Panther	1	1.100	-	-	LDO	PTHR13522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1612
SonicParanoid	1	1.000	-	-		X5460
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800