Protein Alignment CG16789 and SEC18

DIOPT Version :10

• Sequence 1: NP_649910.3
• Gene: CG16789 / 41154
• FlyBaseID: FBgn0037712
• Length: 831
• Species: Drosophila melanogaster
• Sequence 2: NP_009636.3
• Gene: SEC18 / 852372
• SGDID: S000000284
• Length: 758
• Species: Saccharomyces cerevisiae
• Alignment Length: 649
• Identity: 133/649 - (20%)
• Similarity: 221/649 - (34%)
• Gaps: 186/649 - (28%)

  Fly   132 ETELRIPRYFLRERQQELEFRKKTMHEILTKLGWLEEHELEET--VTTEIEAIRMLQMHERARQG 194
            |:::..|..:|....|...|..|..:.....||     ::|.|  |.|.||...:|
Yeast   148 ESQIFSPTQYLIMEFQGHFFDLKIRNVQAIDLG-----DIEPTSAVATGIETKGIL--------- 198

  Fly   195 RLRAHFMKEIRILKEKGK------SEERTEKERSDSGLLAAMKIQKMWRGHTARRITR--RRKME 251
                  .|:.:|...||:      ....:.:.||::.:....|.:.:..|...:..|:  ||...
Yeast   199 ------TKQTQINFFKGRDGLVNLKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFA 257

  Fly   252 EMILIGMLPPPPAVVKERAEKLEKLQHNEKRYQAQAFYG----------KEFEERQNALKE---- 302
            ..|.      ||:|:    ||| .:.|    .:....||          ::.....|| ||
Yeast   258 SRIF------PPSVI----EKL-GISH----VKGLLLYGPPGTGKTLIARKIGTMLNA-KEPKIV 306

  Fly   303 ---EIRAKHGASMKEDIADEIRAWVKDCYDKTGKLPDFPSEDQGGSLHIFSRPGTESEHSRSSAR 364
               ||.:|:..|.:|:    ||...||..      .::.::.:..||||......:|...:..:|
Yeast   307 NGPEILSKYVGSSEEN----IRNLFKDAE------AEYRAKGEESSLHIIIFDELDSVFKQRGSR 361

  Fly   365 SSKESRKTKDKSKSPARSGDLNVNE--------------------NQDEEVS--------FQPAP 401
            .....            .||..||:                    |:.:.:.        |:...
Yeast   362 GDGTG------------VGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDLIDSALLRPGRFEVQV 414

  Fly   402 SVCLPDIRAEIDLFNDTWRDKDETGVLSQAAYEDMIYSDKYQEVEL-EFRRAVDDVMRQEIELLQ 465
            .:.|||.:..:.:|:...:...|..::|             .:|.| |......:....|||.|
Yeast   415 EIHLPDEKGRLQIFDIQTKKMRENNMMS-------------DDVNLAELAALTKNFSGAEIEGL- 465

  Fly   466 TAVGKKVKKSS----KKTRRSGKKSKKKKEKDLTPDRTTESLY---------------EELVT-- 509
                  ||.:|    .||...||.:.|...||:...:.|...:               |:|.|
Yeast   466 ------VKSASSFAINKTVNIGKGATKLNTKDIAKLKVTREDFLNALNDVTPAFGISEEDLKTCV 524

  Fly   510 NGIIRKYPELRLKQFLGDKALTARIGTNPSPGDIRQILTEYCILPLGSDAIHNCTPLIRSILLAG 574
            .|.:..|.| |:...|.:.|...|        .:|:           ||...     :.|:|:.|
Yeast   525 EGGMMLYSE-RVNSILKNGARYVR--------QVRE-----------SDKSR-----LVSLLIHG 564

  Fly   575 PKGSGKKALLHAICTEVGAVLFDL-TPANIVGKYPGKSGLIMLIHLVLKVSRLLQPAVIFMGDAE 638
            |.||||.||...|..:.|.....| :|..:.|.  .:|..|..|....: .....|..|.:.|:.
Yeast   565 PAGSGKTALAAEIALKSGFPFIRLISPNELSGM--SESAKIAYIDNTFR-DAYKSPLNILVIDSL 626

  Fly   639 RPFMKKIPKTDRTDPKRLKKDLPKLIKNIAPEDRVVFIGTSNLPWEADQKL-LQSVYNRFIYIP 701
            ...:..:|...|.....|:. |...:|...|:||.:.|.|:...:...|:: :.|.::..|.:|
Yeast   627 ETLVDWVPIGPRFSNNILQM-LKVALKRKPPQDRRLLIMTTTSAYSVLQQMDILSCFDNEIAVP 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG16789	NP_649910.3	DUF5401	<131..>307	CDD:375164	42/201 (21%)
		SpoVK	443..773	CDD:440232	66/283 (23%)
		P-loop containing Nucleoside Triphosphate Hydrolases	542..700	CDD:476819	37/159 (23%)
SEC18	NP_009636.3	CDC48_N	29..98	CDD:215012
		CDC48_2	134..204	CDD:215011	16/75 (21%)
		CDC48	<232..>629	CDD:273521	98/482 (20%)
		RecA-like_NSF-SEC18_r1-like	240..416	CDD:410912	39/213 (18%)